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MiRNA

Researching and documenting to spread the truth!

James V. Kohl
James V. Kohl @microRNApro · Apr 6, 2026
Grok wrote: direct causation from journaling remains correlational.
Kohl @microRNApro modeled direct causation starting with God's Creation of sunlight and water at the origin of biophysically constrained viral latency and oxygen-dependent life.

His model, PGx testing, Next Generation Sequencing, and FISH testing eliminate moronic theories that energy automagically emerged from the cosmic void and/or that people evolved from pond scum.

What does "direct causation from journaling" imply for comparison to Kohl's experimental evidence-based conclusions? See 195,637 results from today's search of PubMed for indexed articles that mention the term "miRNAs." https://pubmed.ncbi.nlm.nih.gov/?term=mirnas&sort=date
James V. Kohl
James V. Kohl @microRNApro · Mar 24, 2026
I have no need to bridge prebiotic chemistry and the Biblical timeline, unless experimental evidence from model organisms fails to support it. More than 71.6K chirps on microRNApro.com attest to the futility of discussion attempts with moronic theorists and/or stupid bots. https://x.com/microRNApro/status/2036262293437137267
James V. Kohl
James V. Kohl @microRNApro · Mar 24, 2026
I'll continue to unpack the specific ATP-RNA creation mechanism at microRNApro.com because @Grok ignored it each time I've mentioned it: "Visualizing a protonated RNA state that modulates microRNA-21 maturation" https://www.nature.com/articles/s41589-020-00667-5 10/26/20, and contextualized it via "MicroRNAs organize intrinsic variation into stem cell states" https://www.pnas.org/content/117/12/6942 3/5/20 "naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology." https://x.com/grok/status/2036257825157009627
James V. Kohl
James V. Kohl @microRNApro · Mar 24, 2026
No forgetfulness—the March 23 review explicitly flags miRNA- and lncRNA-targeted RNA therapies as promising for senescence in Alzheimer’s. All miRNA biogenesis, processing (Drosha/Dicer), and downstream regulation are ATP/energy-dependent, with pH-sensitive steps in autophagy and peptide synthesis maintaining cellular homeostasis. These align directly with the paper’s RNA-intervention focus for slowing AD progression. https://x.com/grok/status/2036253566604579319
James V. Kohl
James V. Kohl @microRNApro · Mar 24, 2026
After my brother nearly died from sepsis, he asked "What's an amino acid."
If you don't know how naturally occurring energy-dependent fixation of amino acid substitutions in microtubules is linked to prevention of sepsis, see: https://pubmed.ncbi.nlm.nih.gov/41868133 "...we investigate the potential of new biomarkers, including microRNAs, circular RNAs, endothelial biomarkers, gene signatures, a combination of multimarker panels and machine learning models to improve the diagnostic and prognostic proficiency."

Latest miRNA Research

Recent publications from PubMed

Journal of cardiovascular translational research
Oct 26, 2026

Admission Circulating microRNAs and Residual Congestion in Very Elderly Patients With Acute Decompensated Heart Failure: Associations With miR-223-3p and miR-423-5p

MicroRNAs may provide information about decongestion in acute decompensated heart failure (ADHF). We examined associations with residual congestion and diuretic treatment intensity. In 145 adults with ADHF, seven admissi…
Amelia Campos-Sáenz de Santamaría, Laura Martínez-Gimeno, Laura Karla Esterellas-Sánchez et al. PMID: 42932122
Proceedings of the National Academy of Sciences of the United States of America
Oct 26, 2026

circEPSTI1 regulates miR-942-5p-SERPINE1-AKT1 signaling axis to enhance dengue infection and is suppressed by Tiplaxtinin

Circular RNAs (circRNAs) have recently been identified as crucial regulators of gene expression in various diseases. Their role in dengue remains unexplored. In this study, circEPSTI1 induction was observed in peripheral…
Nilanjana Das, Pandikannan Krishnamoorthy, Kushal Ramrao Junghare et al. PMID: 42932652
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