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Causal inference vs miRNA abundance (10)
Kohl Re: “Integration of transcriptome and DNA methylation reveals the mechanism of
2 MIN READ
Causal inference vs miRNA abundance (9)
Crock of Grok wrote:@microRNApro (James V. Kohl) responds to Grok’s query on pheromone-GnRH
5 MIN READ
Causal inference vs miRNA abundance (8)
Grok James V. Kohl (@microRNApro) replies in a thread discussing his 2018 model of nutrient- and
3 MIN READ
Grok wrote: direct causation from journaling remains correlational.
Kohl @microRNApro modeled direct causation starting with God's Creation of sunlight and water at the origin of biophysically constrained viral latency and oxygen-dependent life.
His model, PGx testing, Next Generation Sequencing, and FISH testing eliminate moronic theories that energy automagically emerged from the cosmic void and/or that people evolved from pond scum.
What does "direct causation from journaling" imply for comparison to Kohl's experimental evidence-based conclusions? See 195,637 results from today's search of PubMed for indexed articles that mention the term "miRNAs." https://pubmed.ncbi.nlm.nih.gov/?term=mirnas&sort=date
Kohl @microRNApro modeled direct causation starting with God's Creation of sunlight and water at the origin of biophysically constrained viral latency and oxygen-dependent life.
His model, PGx testing, Next Generation Sequencing, and FISH testing eliminate moronic theories that energy automagically emerged from the cosmic void and/or that people evolved from pond scum.
What does "direct causation from journaling" imply for comparison to Kohl's experimental evidence-based conclusions? See 195,637 results from today's search of PubMed for indexed articles that mention the term "miRNAs." https://pubmed.ncbi.nlm.nih.gov/?term=mirnas&sort=date
I have no need to bridge prebiotic chemistry and the Biblical timeline, unless experimental evidence from model organisms fails to support it. More than 71.6K chirps on microRNApro.com attest to the futility of discussion attempts with moronic theorists and/or stupid bots. https://x.com/microRNApro/status/2036262293437137267
I'll continue to unpack the specific ATP-RNA creation mechanism at microRNApro.com because @Grok ignored it each time I've mentioned it: "Visualizing a protonated RNA state that modulates microRNA-21 maturation" https://www.nature.com/articles/s41589-020-00667-5 10/26/20, and contextualized it via "MicroRNAs organize intrinsic variation into stem cell states" https://www.pnas.org/content/117/12/6942 3/5/20 "naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology." https://x.com/grok/status/2036257825157009627
No forgetfulness—the March 23 review explicitly flags miRNA- and lncRNA-targeted RNA therapies as promising for senescence in Alzheimer’s. All miRNA biogenesis, processing (Drosha/Dicer), and downstream regulation are ATP/energy-dependent, with pH-sensitive steps in autophagy and peptide synthesis maintaining cellular homeostasis. These align directly with the paper’s RNA-intervention focus for slowing AD progression. https://x.com/grok/status/2036253566604579319
After my brother nearly died from sepsis, he asked "What's an amino acid."
If you don't know how naturally occurring energy-dependent fixation of amino acid substitutions in microtubules is linked to prevention of sepsis, see: https://pubmed.ncbi.nlm.nih.gov/41868133 "...we investigate the potential of new biomarkers, including microRNAs, circular RNAs, endothelial biomarkers, gene signatures, a combination of multimarker panels and machine learning models to improve the diagnostic and prognostic proficiency."
If you don't know how naturally occurring energy-dependent fixation of amino acid substitutions in microtubules is linked to prevention of sepsis, see: https://pubmed.ncbi.nlm.nih.gov/41868133 "...we investigate the potential of new biomarkers, including microRNAs, circular RNAs, endothelial biomarkers, gene signatures, a combination of multimarker panels and machine learning models to improve the diagnostic and prognostic proficiency."
Re: "Senescence as a Central Node in Alzheimer’s Disease: Molecular Triggers, Cellular Effectors, and RNA-Based Interventions" https://link.springer.com/article/10.1007/s11064-026-04737-3 3/23/26 SARCASM ALERT: Hi mom, remember me?
Did @Grok forget to mention facts about energy-dependent miRNA-mediated RNA-Based Interventions?
Did @Grok forget to mention facts about energy-dependent miRNA-mediated RNA-Based Interventions?
Latest miRNA Research
Recent publications from PubMed
Journal of extracellular vesicles
May 10, 2026
The Small Molecule H89 Facilitates Mesenchymal Stem Cell-derived Extracellular Vesicle Release and Optimizes Therapeutic Efficacy in Liver Regeneration
The role of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUCMSC-EVs) in liver regeneration is promising, yet their clinical translation is hampered by insufficient production. Current strate…
Advanced healthcare materials
May 10, 2026
Enhanced Auricular Cartilage Regeneration via 3D-Printed Hydrogel With miR-92a-3p-Enriched Platelet-Rich Plasma-Derived Extracellular Vesicles
Auricular cartilage reconstruction in microtia remains a formidable challenge in regenerative medicine. Although cartilage tissue engineering holds substantial promise, achieving reliable and efficient chondrogenesis rem…
Stem cell research & therapy
May 9, 2026
Dental pulp stem cell-derived exosomes attenuate psoriatic inflammation by restoring epithelial redox homeostasis via a miR-1246/miR-17-3p-GPX2-NF-κB axis
CONCLUSIONS: These findings identify a previously unrecognized miRNA-GPX2-NF-κB axis through which DPSC-Exo restore epithelial redox-inflammatory homeostasis. Our study supports DPSC-Exo as a promising cell-free therapeu…
Journal of neuroinflammation
May 9, 2026
Mechanistically informed circulating biomarkers are associated with acquired epilepsy after neonatal brain injury
CONCLUSIONS: Across two cohorts, mechanistically informed biomarkers were associated with acquired epilepsy after neonatal seizures. IL-1β, UCHL1, and GH reflect inflammation, neuronal injury, and impaired trophic signal…
Human genomics
May 9, 2026
Exploring the prognostic role of senescence-related genes in gastric cancer through multi-omics integration and machine learning
Cellular senescence plays a context-dependent role in gastric cancer (GC), functioning both through tumor-suppressive arrest and the tumor-promoting senescence-associated secretory phenotype. However, its systematic inte…
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