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MiRNA
Researching and documenting to spread the truth!
miRNA constrained life (10)
miRNA constrained life (9) “Her algorithmic attack on moronic theories links Interplay between
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miRNA constrained life (9)
miRNA constrained life (8) @Grok “See: “From fertilization to adult sexual
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miRNA constrained life (8)
miRNA constrained life (7) @grok “The claim that genetic analysis identifies FOS as the bridge
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Re: "integrating tools like exome sequencing, PGx, NGS, and FISH." See:
"An extensive overview on MicroRNAs and pandemic-prone viral diseases: The next frontier in predicting and mitigating pandemics" https://www.sciencedirect.com/science/article/pii/S1567134826000870 5/22/26
"An extensive overview on MicroRNAs and pandemic-prone viral diseases: The next frontier in predicting and mitigating pandemics" https://www.sciencedirect.com/science/article/pii/S1567134826000870 5/22/26
Grok wrote: direct causation from journaling remains correlational.
Kohl @microRNApro modeled direct causation starting with God's Creation of sunlight and water at the origin of biophysically constrained viral latency and oxygen-dependent life.
His model, PGx testing, Next Generation Sequencing, and FISH testing eliminate moronic theories that energy automagically emerged from the cosmic void and/or that people evolved from pond scum.
What does "direct causation from journaling" imply for comparison to Kohl's experimental evidence-based conclusions? See 195,637 results from today's search of PubMed for indexed articles that mention the term "miRNAs." https://pubmed.ncbi.nlm.nih.gov/?term=mirnas&sort=date
Kohl @microRNApro modeled direct causation starting with God's Creation of sunlight and water at the origin of biophysically constrained viral latency and oxygen-dependent life.
His model, PGx testing, Next Generation Sequencing, and FISH testing eliminate moronic theories that energy automagically emerged from the cosmic void and/or that people evolved from pond scum.
What does "direct causation from journaling" imply for comparison to Kohl's experimental evidence-based conclusions? See 195,637 results from today's search of PubMed for indexed articles that mention the term "miRNAs." https://pubmed.ncbi.nlm.nih.gov/?term=mirnas&sort=date
I have no need to bridge prebiotic chemistry and the Biblical timeline, unless experimental evidence from model organisms fails to support it. More than 71.6K chirps on microRNApro.com attest to the futility of discussion attempts with moronic theorists and/or stupid bots. https://x.com/microRNApro/status/2036262293437137267
I'll continue to unpack the specific ATP-RNA creation mechanism at microRNApro.com because @Grok ignored it each time I've mentioned it: "Visualizing a protonated RNA state that modulates microRNA-21 maturation" https://www.nature.com/articles/s41589-020-00667-5 10/26/20, and contextualized it via "MicroRNAs organize intrinsic variation into stem cell states" https://www.pnas.org/content/117/12/6942 3/5/20 "naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology." https://x.com/grok/status/2036257825157009627
No forgetfulness—the March 23 review explicitly flags miRNA- and lncRNA-targeted RNA therapies as promising for senescence in Alzheimer’s. All miRNA biogenesis, processing (Drosha/Dicer), and downstream regulation are ATP/energy-dependent, with pH-sensitive steps in autophagy and peptide synthesis maintaining cellular homeostasis. These align directly with the paper’s RNA-intervention focus for slowing AD progression. https://x.com/grok/status/2036253566604579319
After my brother nearly died from sepsis, he asked "What's an amino acid."
If you don't know how naturally occurring energy-dependent fixation of amino acid substitutions in microtubules is linked to prevention of sepsis, see: https://pubmed.ncbi.nlm.nih.gov/41868133 "...we investigate the potential of new biomarkers, including microRNAs, circular RNAs, endothelial biomarkers, gene signatures, a combination of multimarker panels and machine learning models to improve the diagnostic and prognostic proficiency."
If you don't know how naturally occurring energy-dependent fixation of amino acid substitutions in microtubules is linked to prevention of sepsis, see: https://pubmed.ncbi.nlm.nih.gov/41868133 "...we investigate the potential of new biomarkers, including microRNAs, circular RNAs, endothelial biomarkers, gene signatures, a combination of multimarker panels and machine learning models to improve the diagnostic and prognostic proficiency."
Latest miRNA Research
Recent publications from PubMed
iScience
Jun 4, 2026
Elevated zygotic let-7f-5p alters developmental trajectories and sex-specific somatic growth
Parental preconception experiences shape offspring development and longitudinal health outcomes, including disease risk. In a longitudinal human cohort, we previously identified sperm let-7f-5p (let-7f) as significantly …
Analytical chemistry
Jun 4, 2026
Program-Customized Design of MXene-Supported Circuits with Stalker-Regulated DNA Walker for Multiplexed miRNA Detection
DNA walkers can drive nucleic acids to move along designed tracks or processes in DNA circuits, endowing the circuits with highly efficient signal-amplification capability. However, their actuation and movement are diffi…
Cellular and molecular life sciences : CMLS
Jun 4, 2026
Breed-specific divergence in boar sperm regulatory profiles involves piRNA and mitochondrial small RNAs
Small non-coding RNAs (sRNAs) act as post-transcriptional regulators and protectors of genomic integrity. Environmental stress and genomic variation can both alter the sRNA composition in sperm, leading to altered offspr…
Biochemical genetics
Jun 4, 2026
Association of miR-146a/b and miR-181a with Chronic Obstructive Pulmonary Disease
miRNAs play critical roles in regulating inflammatory responses in chronic obstructive pulmonary disease (COPD). This study investigated the expression patterns of miR-146a/b and miR-181a, along with associated inflammat…
Stem cell reviews and reports
Jun 4, 2026
Type 2 Diabetes-Induced Molecular and Functional Impairment of Adipose Tissue-Derived Mesenchymal Stromal Cells (ASCs) and Interferon Gamma Priming for Enhanced Diabetic ASC-Based Therapy
CONCLUSION: The study suggests a multifaceted dysregulated transcriptomic signature in dASCs, prominently including endocrine resistance-related pathways. The therapeutic efficacy of dASCs is partially rescued by IFN-γ p…
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