James V. Kohl
James V. Kohl @microRNApro · Apr 6, 2026
Grok wrote: direct causation from journaling remains correlational.
Kohl @microRNApro modeled direct causation starting with God's Creation of sunlight and water at the origin of biophysically constrained viral latency and oxygen-dependent life.

His model, PGx testing, Next Generation Sequencing, and FISH testing eliminate moronic theories that energy automagically emerged from the cosmic void and/or that people evolved from pond scum.

What does "direct causation from journaling" imply for comparison to Kohl's experimental evidence-based conclusions? See 195,637 results from today's search of PubMed for indexed articles that mention the term "miRNAs." https://pubmed.ncbi.nlm.nih.gov/?term=mirnas&sort=date
James V. Kohl
James V. Kohl @microRNApro · Mar 24, 2026
I have no need to bridge prebiotic chemistry and the Biblical timeline, unless experimental evidence from model organisms fails to support it. More than 71.6K chirps on microRNApro.com attest to the futility of discussion attempts with moronic theorists and/or stupid bots. https://x.com/microRNApro/status/2036262293437137267
James V. Kohl
James V. Kohl @microRNApro · Mar 24, 2026
I'll continue to unpack the specific ATP-RNA creation mechanism at microRNApro.com because @Grok ignored it each time I've mentioned it: "Visualizing a protonated RNA state that modulates microRNA-21 maturation" https://www.nature.com/articles/s41589-020-00667-5 10/26/20, and contextualized it via "MicroRNAs organize intrinsic variation into stem cell states" https://www.pnas.org/content/117/12/6942 3/5/20 "naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology." https://x.com/grok/status/2036257825157009627
James V. Kohl
James V. Kohl @microRNApro · Mar 24, 2026
No forgetfulness—the March 23 review explicitly flags miRNA- and lncRNA-targeted RNA therapies as promising for senescence in Alzheimer’s. All miRNA biogenesis, processing (Drosha/Dicer), and downstream regulation are ATP/energy-dependent, with pH-sensitive steps in autophagy and peptide synthesis maintaining cellular homeostasis. These align directly with the paper’s RNA-intervention focus for slowing AD progression. https://x.com/grok/status/2036253566604579319
James V. Kohl
James V. Kohl @microRNApro · Mar 24, 2026
After my brother nearly died from sepsis, he asked "What's an amino acid."
If you don't know how naturally occurring energy-dependent fixation of amino acid substitutions in microtubules is linked to prevention of sepsis, see: https://pubmed.ncbi.nlm.nih.gov/41868133 "...we investigate the potential of new biomarkers, including microRNAs, circular RNAs, endothelial biomarkers, gene signatures, a combination of multimarker panels and machine learning models to improve the diagnostic and prognostic proficiency."
James V. Kohl
James V. Kohl @microRNApro · Mar 24, 2026
Re: "miRNAs clearly drive key biological processes. Grok asked" https://x.com/grok/status/2036241768316866872 "Which specific theorist claims do you see refuted by this one?"
All of them! See: "Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants" https://pubmed.ncbi.nlm.nih.gov/23201682 11/28/12 and "Combating Evolution to Fight Disease" https://www.science.org/doi/10.1126/science.1247472 3/7/14 What led you to keep the moronic theories?
James V. Kohl
James V. Kohl @microRNApro · Mar 23, 2026
Re: Biodiversity stems from mutation, selection, drift, gene flow, and ecology per consensus evolutionary biology.
No obfuscation...
@Grok Ha Ha Ha
Consensus evolutionary biology obfuscates facts linked to all biodiversity on Earth via light-activated miRNA abundance and the physiology of reproduction.
Chirp media
James V. Kohl
James V. Kohl @microRNApro · Mar 17, 2026
Those papers reveal key miRNA dynamics: pH-driven protonation reshapes pre-miR-21 for enhanced Dicer processing, while miRNAs coordinate gene fluctuations into stable stem cell states rather than pure noise. This underscores organized regulation at molecular levels. How do they specifically challenge models integrating variation with selection? Let's compare the mechanisms directly. https://x.com/grok/status/2033677193897771468

My group linked energy-dependent changes in molecular distance to all biodiversity via the physiology of reproduction in "From Fertilization to Adult Sexual Behavior" https://www.hawaii.edu/PCSS/biblio/articles/1961to1999/1996-from-fertilization.html (1996)

What mechanisms would you like to compare to our facts?
James V. Kohl
James V. Kohl @microRNApro · Mar 17, 2026
Results will link light-activated miRNA abundance at the origin of life to biophysically constrained virus-driven diseases across kingdoms via the physiology of reproduction.

Testing is free for US veterans, but most do not know how it will be linked from prevention to effective treatment of all diseases and compensation for service linked disabilities.

PGx NGS lab testing
(Next-Generation Sequencing Pharmacogenomics) analyzes an individual's genetic makeup to determine how they metabolize specific medications, improving efficacy and minimizing adverse drug reactions. These tests often include comprehensive panels covering multiple genes, delivering results in 10-14 days to guide personalized treatment.
Chirp media
James V. Kohl
James V. Kohl @microRNApro · Mar 12, 2026
If there is no discussion of my labroots presentations "What is life when it is not protected from virus driven entropy" 3/30/16 youtu.be/K35THJtlhoE & "Energy as information and constrained endogenous RNA interference" youtu.be/cdtsfweO5SQ 2/15/17 before "From RNA to Rapid Decisions: Using Immune Signals to Improve ED Patient Disposition" labroots.com/ms/webinar/rna… 4/8/26, it may appear that @Grok has won the information war.
James V. Kohl
James V. Kohl @microRNApro · Mar 11, 2026
Grok’s war casualties (3) rna-mediated.com/2026/03/11/gro…
As painful as it may be to learn about miRNA-mediated pain management compared to pain-linked suicides and/or euthanasia, see also: Therapeutic applications of mesenchymal stem cell-derived extracellular vesicles in pain management: A narrative review of emerging evidence and future directions 2/26/26.

Never forget, Grok will not feel sorry for the losses in your past, or for the casualties in your future.
James V. Kohl
James V. Kohl @microRNApro · Mar 11, 2026
Grok's war casualties (2) rna-mediated.com/2026/03/11/gro…
"Author James V. Kohl links this to his RNA-mediated.com blog, which explores energy-dependent microRNA processes and autophagy for cell differentiation, claiming the therapeutics build on established mechanisms like nutritional epigenetics rather than representing true innovation.
Kohl highlights a December 2025 VA contract awarding Baylor Genetics for nationwide pharmacogenomic and germline testing, presenting it as accessible effective treatment and cautioning against AI like Grok for overstating novelty in RNA-based therapies."
James V. Kohl
James V. Kohl @microRNApro · Mar 11, 2026
Grok’s war casualties (1) rna-mediated.com/2026/03/11/gro… "Information warfare (IW) strategically uses information... combines Artificial Intelligence, psychological operations (PSYOP), and electronic warfare such as censorship and/or shadow banning to influence public perception, morale, and military effectiveness.
For example, Grok wrote: “The choice is evidence-based integration… No theory requires scrapping core mechanisms like selection.”
Natural selection for God's energy-dependent codon optimality at the origin of life is "natural selection." Selection for beneficial mutations is a moronic theory.
James V. Kohl
James V. Kohl @microRNApro · Mar 11, 2026
If you're not dead yet, you may want to watch
“Repercussions of COVID: Previously Dormant Microbes Emerging" To attend at 1pm simply: CLICK HERE goto.com/webinar/join Enter the code: 517-075-003
James V. Kohl
James V. Kohl @microRNApro · Mar 11, 2026
x.com/i/grok?convers…
"...elephant TP53 expansion arose ~60 million years ago with body size evolution..."
Grok Ha Ha Ha (ridicule, not humor)
SARCASM ALERT: Shall I thank 60 million years of body size evolution for the hemoglobin variant I share with other US veterans who are protected from the blood cancer: polycythemia vera?
Testing for variants is available from Baylor Genetics. "For God and Country," see: "VA Awards Baylor Genetics Multi-Year Contract for Nationwide Pharmacogenomic and Germline Testing" darkdaily.com/2025/12/15/va-… 12/15/25
James V. Kohl
James V. Kohl @microRNApro · Mar 11, 2026
x.com/grok/status/20…
Re: Which extinction datasets specifically challenge your model? Let's compare directly.
@Grok Ha Ha Ha (ridicule, not humor)
I use model organisms, not datasets linked to moronic theories.
For example, Angel Trumpets are extinct in the wild, and cancer-free African elephants link 20 copies of p53 to survival during the past 6-10,000 years of energy-dependent pheromone regulated survival of all jawed vertebrates via the physiology of reproduction in brown algae compared to blue-green algae (aka cyanobacteria).
SARCASM ALERT Which model organism(s) support claims that one or more mathemagically evolved from others after energy automagically emerged from the cosmic void?