In the era of personalized medicine, the development of affordable, portable biosensors for early, noninvasive diagnosis and screening of oral squamous cell carcinoma (OSCC)-particularly in remote areas-is imperative. Co…

CONCLUSION: While current applications of discovered miRNAs primarily focus on early diagnosis and prognosis of cardiac conditions, their therapeutic potential holds promise for revolutionizing the management of various …

CONCLUSIONS: Our study demonstrated the feasibility, efficacy and the possible mechanism of mesenchymal stromal cell-derived engineered exosomes, positioning them as a potential cell-free intervention for DMD-associated …

DNA-based nanomachines hold great promise for intracellular miRNA sensing and cancer diagnosis. However, conventional approaches often suffer from insufficient sensitivity and specificity, which limits their applicabilit…

The intricate intercellular communication within the tumor microenvironment (TME) critically drives cancer progression and therapeutic resistance. Natural killer (NK) cells are potent sentinels of the innate immune syste…

Extracellular vesicles have emerged as promising cell-free therapeutic agents for wound healing due to their remarkable ability to modulate inflammatory responses, promote angiogenesis, and enhance tissue regeneration. T…

LncRNA NR_003508 has been implicated in lipopolysaccharide (LPS)-induced acute respiratory distress syndrome. Yet, the involvement of LncRNA NR_003508 in Pseudomonas aeruginosa (PA)-induced autophagy remains elusive. Thi…

With the growing of the global population aging, the comorbidity of cardiovascular disease (CVD) and Alzheimer's disease (AD) has gradually become a major contributor to global disease burden, with the two diseases exhib…

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by amyloid-β (Aβ) deposition, tau hyperphosphorylation, neuroinflammation, mitochondrial dysfunction, and oxidative stress. Despite re…

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CONCLUSIONS: Although EV-associated microRNAs offer promising opportunities for biomarker discovery, risk stratification, and targeted therapies, clinical translation remains limited by heterogeneity in EV isolation, mic…

Nutritional genomics has expanded our understanding of how dietary exposures interact with genetic and epigenetic mechanisms involved in metabolic dysfunction. In this context, metabolic dysfunction associated with exces…

Hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment options, underscoring the urgent need for novel therapeutic targets. The copper transporter ATP7A has been implicated in cancer, but its precis…

MiRNAs have emerged as key biomarkers for early disease detection and therapeutic monitoring; yet, their ultrasensitive and specific detection confronts challenges due to low expression levels in biological fluids and hi…

Atopic dermatitis (AD) and psoriasis are prevalent chronic inflammatory skin diseases with distinct clinical features and significant impacts on patients' quality of life. AD typically presents as recurrent eczema-like l…

Rheumatic diseases are characterized by chronic inflammation and immune dysregulation that profoundly impair patients' quality of life, yet their underlying pathogenic mechanisms remain incompletely elucidated. Sirtuin 1…

Sertoli cells (SCs) are crucial for testicular development, transitioning from a proliferative to a metabolically active state during puberty to facilitate germ-cell differentiation. However, the molecular switches gover…

Plants frequently encounter recurring, sequential and combined environmental stresses, yet their adaptive capacity cannot be explained solely by immediate signalling and short-term acclimation. Increasing evidence indica…

The cyanobacterial circadian clock, the only rigorously established prokaryotic circadian system, is driven by the KaiABC core oscillator and accompanied by dynamic changes in KaiA and KaiC localization. Because KaiB had…

CONCLUSION: KMT2B is a critical regulator of autophagy and inflammation in atherosclerosis, with Fos-mediated signaling driving its expression. Targeting KMT2B may offer a promising therapeutic strategy for modulating in…

Doxorubicin (DOX) resistance is a major factor limiting the efficacy of chemotherapy in breast cancer. Its development is associated not only with conventional mechanisms, such as enhanced drug efflux, increased DNA dama…

CONCLUSIONS: These findings revealed that LLPS driven by lncRNA Neat1 promotes pressure-overload cardiac remodelling by regulating iron homeostasis. Targeting this process presents a novel RNA-based therapeutic avenue fo…

CONCLUSIONS: KPNA2 expression may serve as an important prognostic biomarker and therapeutic target in patients with locally advanced wild-type p53 CRC.

Molecular crowding in cells is not solely a consequence of excluded volume but emerges from interaction networks shaped by RNA and proteins. Here we examine the physicochemical principles underlying RNA-mediated crowding…

Autoimmune endocrine diseases constitute a group of disorders characterized by immune-mediated destruction or dysfunction of hormone-producing glands. The pathogenesis of these diseases reflects a breakdown of immune tol…

Two MYB transcription factors, GmMYB73 and GmMYB85, were identified as positive regulators of soybean oil biosynthesis. They enhance seed oil content and fatty acid composition through distinct protein interaction partne…

Human genetics implicates innate immunity as a key modifier of tau toxicity, yet human-specific neuroimmune mechanisms remain difficult to test in vivo. Here, we developed HuMiNAX, the first humanized iPSC-based neuroimm…

Alzheimer's disease (AD) progression involves complex molecular mechanisms underlying neuronal dysfunction. While emerging evidence on long noncoding RNAs (lncRNAs) is accumulating, the relevance of nuclear noncoding RNA…

MicroRNAs (miRNAs) are short endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level through mRNA cleavage or translational repression. In plants, miRNAs play pivotal roles in a wide ra…

RNA interference is commonly used as a reverse genetics tool to investigate gene function. In insects, this is achieved by introducing double-stranded RNA or synthetic short-interfering RNAs (siRNAs). However, RNA activa…