The role of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUCMSC-EVs) in liver regeneration is promising, yet their clinical translation is hampered by insufficient production. Current strate…

Auricular cartilage reconstruction in microtia remains a formidable challenge in regenerative medicine. Although cartilage tissue engineering holds substantial promise, achieving reliable and efficient chondrogenesis rem…

CONCLUSION: These findings suggest that miR-466f-3p regulates innate immunity by promoting pro-inflammatory activation of macrophages and contributes to the suppression of metastasis. iPS-EVs represent a promising platfo…

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In recent years, circular RNAs (circRNAs), a class of RNA molecules characterized by a covalently closed circular structure, have emerged as a complex family of eukaryotic transcripts with distinctive biological features…

TB remains a significant global health burden due to protracted therapeutic courses, poor patient compliance, and toxicities associated with drug treatment, as well as concerns arising from increasingly prevalent multidr…

Inflammation serves as a self-defense mechanism against invading bacteria. However, overactive inflammation has the potential to disturb immune balance, thereby triggering heightened inflammatory responses or autoimmune …

Identifying long non-coding RNA (lncRNA) and microRNA (miRNA) interactions (LMIs) is essential for elucidating post-transcriptional regulation and disease-related molecular mechanisms. Accurate identification of LMIs can…

Lung cancer persists as a critical global health challenge and drives innovation in therapeutic strategies to combat it. MicroRNAs (miRNAs) have emerged as promising therapeutic agents because of their pivotal role in ge…

MicroRNAs are non-coding RNAs that regulate gene expression at the post-transcriptional level. To aid research on support the study of microRNAs in goat milk, we provide a dataset describing the microRNA profiles of smal…

Recurrent miscarriage (RM), a complex pregnancy disorder with largely undefined molecular mechanisms, has been associated with epigenetic abnormalities in chorionic tissue. This study aimed to elucidate methylation-depen…

Osteoarthritis (OA) is a chronic, disabling condition whose pathogenesis remains unclear. TRPM4 is closely associated with OA, but its specific roles and regulatory networks within different cell subsets remain to be elu…

CONCLUSIONS: These findings identify a previously unrecognized miRNA-GPX2-NF-κB axis through which DPSC-Exo restore epithelial redox-inflammatory homeostasis. Our study supports DPSC-Exo as a promising cell-free therapeu…

CONCLUSIONS: Across two cohorts, mechanistically informed biomarkers were associated with acquired epilepsy after neonatal seizures. IL-1β, UCHL1, and GH reflect inflammation, neuronal injury, and impaired trophic signal…

Cellular senescence plays a context-dependent role in gastric cancer (GC), functioning both through tumor-suppressive arrest and the tumor-promoting senescence-associated secretory phenotype. However, its systematic inte…

CONCLUSION: This review summarizes the current research progress on ncRNAs regulating macrophage polarization in COPD, with the aim of deepening the understanding of the underlying molecular mechanisms, identifying novel…

The egg cytoplasm undergoes large-scale remodeling after fertilization. Here, we reveal that the germ granule component, HERD-1, is involved in selective degradation of maternal plasma membrane proteins after fertilizati…

Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, has been implicated in cardiometabolic inflammation; however, the intracellular signaling mechanisms linking TMAO to macrophage polarization remain inco…

CONCLUSION: Our findings suggest that Sez6l, which is transcriptionally regulated by Foxo1, facilitates neuropathic pain through activating the Wnt5a/Ca^(2+) signaling pathway in DRGs.

Spinal cord injury (SCI) is characterized by primary mechanical trauma and subsequent secondary pathogenic cascades, with chronic neuroinflammation impeding neurological functional recovery. Microglial activation, mitoch…

INTRODUCTION: Tomato yellow leaf curl virus (TYLCV, Begomovirus coheni), a whitefly-transmitted begomovirus, causes serious economic losses to tomato crops globally. Over the past three decades, several genetic sources o…

Cap-adjacent 2'-O-ribose methylation (cOMe) of the first two transcribed nucleotides of RNA polymerase II transcripts is a conserved feature in many eukaryotes. In mammals, these modifications are key to a transcript sur…

CONCLUSIONS: This study establishes a spinal chordoma PDO platform for functional precision oncology. Our findings identify a TP53-dependent DNA-damage vulnerability engaged by gemcitabine in patient-derived three-dimens…

In order to explore the role of piwil1 (Piwi-like RNA-mediated gene silencing 1) in sex differentiation and gonadal development of largemouth bass (Micropterus salmoides). To this end, we established a 17β-estradiol (E2)…

Chronic heat stress (CHS) disrupts broiler breast muscle physiology homeostasis, yet the underlying molecular mechanisms remain unclear. In this study, 144 male Arbor Acres broilers (28 d old) were randomly allocated int…

Viroids are the smallest known nucleic acid-based infectious agents of plants and consist of single-stranded, circular, non-coding RNAs that can cause significant crop diseases. The potato spindle tuber viroid (PSTVd), a…

Ewing sarcoma (ES) is an aggressive bone tumor in children and adolescents, and metastatic dissemination remains the major cause of treatment failure. Protocadherin 17 (PCDH17), a member of the cadherin superfamily, has …

The mortality rate of head and neck squamous cell carcinoma (HNSCC), one of the most prevalent types of cancer, has remained unchanged despite advances in treatment strategies. Angiopoietin‑like 4 (ANGPTL4) exhibits both…

Transcriptome sequencing is essential for understanding gene expression and RNA features. However, short-read RNA sequencing struggles to analyze complex and full-length messenger RNA molecules. These limitations primari…

Methyltransferase PRC2 (Polycomb Repressive Complex 2) deposits histone H3K27 trimethylation to establish and maintain epigenetic gene silencing. PRC2 is precisely regulated by accessory proteins, histone post-translatio…