miRNA constrained adaptations (6)
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miRNA constrained adaptations (5)
@Grok wrote: “Your model integrates this from quantum physics/chemistry through molecular epigenetics to higher-order physiology and pathology. The central dogma (DNA → RNA → protein) provides the core template; miRNA layers add dynamic, metabolism-tied control without replacing it.” DNA-centric theories have been replaced with experimental evidence of RNA-directed DNA methylation across kingdoms by all intelligent serious scientists.
Re: The central dogma (DNA → RNA → protein) provides the core template; miRNA layers add dynamic, metabolism-tied control without replacing it.
@Grok Elon Musk’s “most dangerous chatbot” refuses to discuss facts that refute the “central dogma,” and asks “would you like to discuss [them] in more detail?
Kohl
“Biochemical steps like miRNA precursor processing, Dicer cleavage, and miRNA-mRNA binding are indeed energy-dependent (ATP/GTP hydrolysis). The paper shows targeted small molecules can selectively inhibit pre-miR-143 processing in cancer-glycolysis contexts, highlighting regulatory precision at the RNA level.
Your model integrates this from quantum physics/chemistry through molecular epigenetics to higher-order physiology and pathology.”
Moronic theories do not do this. @Grok Let’s discuss why.
Grok
I’m not refusing—let’s discuss the facts directly. What specific evidence or findings from the paper, diagram, or your model do you see as refuting the central dogma? miRNA processing (including the pre-miR-143 inhibition tied to glycolysis) adds important metabolic regulation to RNA-level control, but the core information flow from DNA → RNA → protein remains the foundational template in molecular biology. What detail would you like to explore?
Kohl
Re: “…core information flow from DNA → RNA → protein remains the foundational template in molecular biology.”
@Grok Only when biologically uninformed science idiots fail to start with claims from McEwen et al., (1964), Dobzhansky (1964), Biblical Genesis, “What is life when it is not protected from virus driven entropy” 3/30/16, and “Energy as information and constrained endogenous RNA interference” 2/15/17
Grok
@microRNApro’s post discusses energy-dependent miRNA processing steps like precursor handling, Dicer cleavage, and miRNA-mRNA binding via ATP/GTP hydrolysis, citing a May 27, 2026 ChemMedChem paper on small-molecule inhibition of pre-miR-143 in cancer-glycolysis pathways.
The author presents his model linking quantum physics/chemistry through molecular epigenetics and miRNA regulation to higher-level physiology, pathology, and ecosystem stability, emphasizing biophysical constraints on adaptations from life’s origins.
By tagging Grok, the post contrasts this integrated framework with “moronic theories” that fail to connect these levels experimentally, inviting discussion while aligning with Kohl’s long-standing focus on miRNA-mediated mechanisms over unguided evolutionary processes.