miRNA constrained adaptations (7)

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miRNA constrained adaptations (6) Grok wrote:

@microRNApro‘s post discusses energy-dependent miRNA processing steps like precursor handling, Dicer cleavage, and miRNA-mRNA binding via ATP/GTP hydrolysis, citing a May 27, 2026 ChemMedChem paper on small-molecule inhibition of pre-miR-143 in cancer-glycolysis pathways. The author presents his model linking quantum physics/chemistry through molecular epigenetics and miRNA regulation to higher-level physiology, pathology, and ecosystem stability, emphasizing biophysical constraints on adaptations from life’s origins. By tagging Grok, the post contrasts this integrated framework with “moronic theories” that fail to connect these levels experimentally, inviting discussion while aligning with Kohl’s long-standing focus on miRNA-mediated mechanisms over unguided evolutionary processes.

See also: Who accelerated apathy (6), and my group’s review of RNA-directed DNA methylation: From Fertilization to Adult Sexual Behavior (1996).

Moving forward:

Alzheimer’s disease neuropathology plasma biomarkers and cognition in midlife: a community-based cohort study 5/30/26 was presciently reported on 5/27/26 as 125 years of ‘science for the benefit of humanity

“…focus on understanding how a process works—in her case, a gut hormone that regulates blood sugar—resulted in applications that no one predicted. What are we now learning about human disease from GLP-1 medications?”

Conclusion: “The people who have worked here throughout the last 125 years constitute a continuing source of inspiration matched by the current inhabitants of our laboratories who are creating the legacy for next generation. It will be fascinating to see the directions taken and discoveries made in the coming years.”

For comparison, see: DNA Methylation Stochasticity is Linked to Transcriptional Variability and Convergent Epigenetic Disruption Across Genetic Subtypes of Acute Myeloid Leukemia 3/16/26, Non-Mendelian inheritance of DNA methylation patterns in mice 5/20/26 reported as: Reported three decades later as: Epigenetics Break the Bounds of Mendelian Inheritance 5/25/26

“The [RNA-directed] DNA methylation seemingly appeared out of nowhere,” said Feinberg.

For a challenge to Feinberg’s DNA methylation “appeared out of nowhere claim, see:
Sex-Biased Pharmacotherapeutic Disparities in Hypertension 5/29/26

“…multi-omic and systems approaches should be prioritized to link sex-specific genomics, epigenomics, immune profiles, microbiome signatures, and pharmacokinetics/pharmacodynamics to antihypertensive response and toxicity.

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