miRNA Creation and life (7)

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miRNA Creation and life (6) Grok wrote: “mdpi.com Research is active on miRNA-based therapies (delivery challenges remain, e.g., crossing BBB via nanoparticles). For the 1996 Hormones and Behavior work or specific PubMed links mentioned earlier, let me know if you’d like deeper dives into those. How else can I explore this (e.g., specific miRNAs, therapies, or models)?”

@Grok My group’s 1996 publication “From Fertilization to Adult Sexual Behavior” predicted everything now known about miRNA-mediated therapies before the term pre-mRNA was changed to miRNA. See: “mirna” 198,742 results

Grok wrote: Research is active on miRNA-based therapies (delivery challenges remain, e.g., crossing BBB via nanoparticles). For the 1996 Hormones and Behavior work or specific PubMed links mentioned earlier, let me know if you’d like deeper dives into those. How else can I explore this (e.g., specific miRNAs, therapies, or models)?

Re: exploration deterred

Grok
The post presents summaries on pH-dependent peptide synthesis, where pH controls protonation states, nucleophilicity, and competing pathways, serving as a key factor in chemical evolution, prebiotic oligomer formation, and responsive biomaterials.
It examines prebiotic activation strategies that support longer oligomers, catalysis, protocell development, and transitions toward an RNA-peptide world by integrating RNA, peptide, and lipid chemistries under varying conditions.
Author James V. Kohl (@microRNApro) tags @Grok to assert that gene-centric evolutionary models based on fossil records were overturned 30 years ago by his 1996 Hormones and Behavior paper, which expanded on non-gonadal, non-hormonal, and environmental influences in development from fertilization to adult sexual behavior.

Kohl
Re: “…gene-centric evolutionary models based on fossil records were overturned 30 years ago by his 1996 Hormones and Behavior paper, which expanded on non-gonadal, non-hormonal, and environmental influences in development from fertilization to adult sexual behavior.”

@Grok Why doesn’t everyone know that?

See for today’s total number of indexed articles that mention the term “miRNA”

Included are:

Shear-Induced CROSS (Cellular RedOx Spreading Shield) Assembly Sustains Neurotrophic Extracellular Vesicle Production for Functional Neural Networks 11/3/25

The Role of Hypoxia-Regulated MicroRNAs (Hypoxamirs) in Tumor-Associated Macrophage Polarization: A Systematic Review. 5/28/26

A novel role of circCPSF6 regulating antiviral innate immunity via miR-665 and PCBP2-IPS-1 axis in IAV infection 9/8/26

LHX2: a transcription factor in development, homeostasis, repair, and disease 6/12/26

Donkey Milk Exosomes Protect Against Dextran Sulfate Sodium-Induced Colitis by Delivering Anti-Inflammatory miRNAs and Reshaping Gut Microbiota 6/30/26

Discovery and therapeutic delivery of microRNAs targeting deregulated glioblastoma pathways inhibits tumor growth in mice 6/30/26

Association between miRNAs and DEFA4 in coronary artery disease 6/30/26

Physical exercise and miR-146a in type 2 diabetes and obesity: a narrative review 6/30/26

Multi-omics approaches to parkinsonism: genomic, proteomic, and non-coding RNA perspectives 6/30/26

miRNA-CNGC/GLR circuits coordinate heat-stress Ca(2)+ signaling in wheat. 6/30/26

Circular RNAs as molecular bridges: dual regulation of ferroptosis and immunity in cancer 6/14/26

miR-30d-5p promotes beta cell recovery and immunomodulation in type 1 diabetes 6/1/26

A dose-sensitive miR164e-WRKY50-JAZ7 module fine-tunes grain size in rice 6/29/26

Non-canonical ceRNA-independent mechanism of the lncRNA-H19/miR-212-5p axis targeting KLF4 in Hcy-triggered VSMCs dysfunction and atherogenesis 6/29/26

Maternal Western diet alters milk leptin levels and early postnatal leptin handling in rat offspring 6/29/26

Circulating microRNA profiles associated with tick bite and debilitating symptom complexes attributed to ticks (DSCATT) 6/30/26

DHA and EPA alleviate atherosclerosis by synergistically regulating the aorta-liver axis via miRNA networks 6/29/26

UCA1 lncRNA regulates γ-globin expression by modulating the miR-148b/BCL11A axis 6/29/26

Human cytomegalovirus (HHV5) reactivation during lactation. 6/29/26

Epigenetic silencing of miR-141 via core promoter methylation is associated with short-term bladder cancer progression 6/29/26

Extracellular Vesicles From Young Human Myogenic Progenitor Cells Rejuvenate Aged Cells 6/28/26

Engineering spherical nucleic acids for precision cancer therapy: design strategies and medical applications 6/17/26

Abnormal B-Cell Exosome Proapoptotic and Antiapoptotic Cargo in Multiple Sclerosis: Potential Implication in Progressive Disease Biology

Tinnitus Pathophysiology: A Systems Biology Analysis of Gene Networks and Cellular Pathways

Function and mechanism of double-stranded RNA-binding protein 1 in small RNA metabolism in tomato

The number of virus-driven diseases linked to the degradation of mRNA will continue to increase on a daily, weekly, or monthly basis — as it has since 2013.

There appears to be no hope that Grok AI will catch up to the facts, and that it may actively be promoting moronic theories linked to diseases.

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