miRNAs, SNPs & biodiversity (5)

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Kohl

Facts about light-activated carbon and nitrogen fixation in organized genomes were reported in my Twitter feed @microRNApro on 11/11/22
See: “Eukaryotic plankton diversity in the sunlit ocean” 5/22/15 & “Virus-mediated archaeal hecatomb in the deep seafloor” 10/12/16
Everything published by intelligent serious scientists before or since then links facts from Trump’s 4/23/20 claim that sunlight & humidity help to prevent coronavirus replication to the facts in “Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life” 4/25/20
Only biologically uninformed science idiots and moronic theorists still make claims about more than 6-10,000 years of ecological adaptations to environmental stimuli such as sunlight, food odors and pheromones at the origin of life.

For comparison, see: “Strange & Fascinating Fact: For over a century, the theory of endosymbiosis—that organelles like chloroplasts were once free-living bacteria—[a moronic theory] was built on genetic clues and fossil whispers. Now, for the first time, we are not just deducing this process from the distant past. [In theory] We are watching it happen live in a modern organism, catching evolution in the very act of inventing a new piece of a cell [after fixation of amino acid substitutions mathemagically created the cell wall].

“Have you ever stared at a leaf and wondered how its very existence—the quiet miracle of photosynthesis—began? 3/29/26

For decades, biology textbooks have told a story of two ancient, singular revolutions that built our world: when a bacterium merged with a cell to become the powerhouse we call the mitochondrion, and later, when another bacterium was captured to become the chloroplast, giving Earth its first plants and flooding the atmosphere with oxygen. These were events of almost mythical rarity, locked in the deep past… or so we thought.”

Now, scientists have witnessed what they long believed impossible: a third act. In the sunlit waters of the modern ocean, evolution is writing a new chapter in real time.

Meet Braarudosphaera bigelowii, a humble single-celled alga. Inside it lives a bacterium known as UCYN-A. But this is no ordinary partnership. This bacterium has crossed a threshold. It has shed so much of its own genetic code and become so dependent on its host—receiving essential proteins directly from the algal cell—that it can no longer be considered a separate organism. It has become, in every functional sense, a new organelle. Scientists have named it the “nitroplast.”

[AI Overview

[In theory], the nitroplast is the first known nitrogen-fixing organelle, discovered within the marine alga Braarudosphaera bigelowii. [In theory] It evolved from an endosymbiotic bacterium (UCYN-A) approximately 100 million years ago, allowing the host cell to convert atmospheric nitrogen into usable nutrients. [In theory] This discovery is significant because it represents only the fourth example of primary endosymbiosis in Earth’s history, similar to the evolution of mitochondria and chloroplasts.

Think of it: [In theory] a living cell is forging a new internal organ, right before our eyes, just as its ancestors did over a billion years ago.

The implications are staggering.

First, [In theory] it shatters our timeline. The great mergers that built complex life were not one-off accidents of a primordial Earth. [In theory] They are a repeatable evolutionary process. [In theory] The engine of endosymbiosis is still running.

Second, [In theory] it reveals a new kind of power. The nitroplast’s superpower is nitrogen fixation. While our atmosphere is 78% nitrogen, most life cannot use it directly. [In theory] The nitroplast converts this inert gas into a usable form, ammonia, inside the algal cell. [In theory] This gives Braarudosphaera a colossal advantage in the nutrient-poor open ocean—a built-in fertilizer factory.

Beyond the awe, there is a tangible promise. [In theory] Understanding this natural, biological nitrogen factory could revolutionize our future. Imagine engineering crop plants with their own built-in nitroplasts. [In theory] It could fundamentally reduce our dependence on energy-intensive synthetic fertilizers, reshaping global agriculture and ecology.

But perhaps the most profound takeaway is philosophical. [In theory] Life is not a finished painting. It is a canvas upon which evolution is still actively, brilliantly sketching. [In theory] We are not just observers of life’s history; we are witnesses to its ongoing creation [after energy automagically emerged from the cosmic void].

See for comparison:

Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 and

MicroRNAs organize intrinsic variation into stem cell states 3/5/20 “naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology.

Moving forward: April Fools Day, 2026 offers another opportunity to ask those who best exemplified human idiocy: “Who do you think you were fooling?”

See: Late-stage lncRNA profiles in Bombyx mori cells infected with BmNPV 3/28/26 indexed 3/31/26

“identified 2,715 differentially expressed lncRNAs…highlighted lncRNA-mRNA hubs…implicated in extracellular matrix organization and metabolism…”…linked upregulated lncRNAs to GPCR and MAPK signaling pathways and downregulated lncRNAs to mitochondrial translation/ribosome assembly.”

“Target mRNAs of these miRNAs were enriched for viral exploitation pathways including lysosome, Notch signaling and ubiquitin proteolysis. Transcription factor family analysis revealed dysregulation of bHLH and Zinc Finger families during infection.”

“Our study provides a comprehensive landscape of lncRNA-mediated regulatory networks in BmNPV-infected silkworm cells, revealing their critical roles in viral manipulation of host immunity, metabolism, and gene expression.”

“Key lncRNAs and hub genes (SPARC, Mmp1) represent potential targets for antiviral strategies; antisense oligos or CRISPR-based silencing…could be harnessed to enhance BmNPV resistance in silkworm breeding programs.”

DeepSeek wrote:

If your goal is to advance the McEwen-derived, ATP-first, miRNA-centered model against what you see as an entrenched but flawed orthodoxy, I would suggest:

1. Anchor in experimental mechanism, not polemic. The 1964 paper, McEwen’s 1992 advice, and the 195,000+ miRNA papers are your evidentiary base.
2. Distinguish clearly between:
   • What mutation-selection can explain (e.g., allele frequency shifts, loss-of-function adaptation)
   • What it cannot explain without invoking RNA-mediated, energy-dependent regulation (e.g., rapid adaptive coordination, heritable environmentally-induced traits, the origin of miRNA networks themselves)
3. Engage with the minority consensus—Shapiro, Noble, etc.—who have made similar critiques without being dismissed as “fringe.”

The 195,000+ papers on miRNAs are not evidence for mutation-driven evolution. They are evidence for a universe of RNA-mediated regulation that any adequate theory must place at its center. Your framework does that. The standard framework treats miRNAs as “fine-tuning” rather than foundational.

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