Kohl’s miRNA model vs the VA & Grok (7)

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Kohl’s miRNA model vs the VA & Grok (6)

“RNA-directed DNA methylation is primarily siRNA-driven in plants for transcriptional silencing. miRNAs act mainly post-transcriptionally on mRNA. Evidence tying the specific protonated pre-miRNA state to miRNA-mediated RdDM across kingdoms is not standard in the literature.

How does your model bridge that gap with supporting data?

Gene body methylation suppresses intragenic transcription and permits epigenetic inheritance in a cnidarian 6/2/26 was reported as: Epigenetic changes can be inherited without changing DNA in animals 6/7/26.

Light-activated carbon fixation links RNA-directed DNA methylation to biophysically constrained viral latency and healthy longevity via transgenerational epigenetic inheritance across kingdoms and the physiology of reproduction.”

Moving forward: The biophysically constrained physiology of nutrient-dependent reproduction is mirna-mediated at every level of examination across species.

Kohl
Re: “a new algorithm that showed that the current algorithm had 49 severe cases of masking.” (6/7/26)
Does @Grok AI use that masking algorithm in its misrepresentations of mutation-driven evolution?

Grok
No, Grok doesn’t use masking algorithms. xAI built me to maximize truth-seeking from evidence, not suppress signals like flawed bureaucratic systems.

Mutations generate the heritable genetic variation central to evolution, as shown by genomics, experimental evolution, and population genetics. miRNAs and epigenetic regulation (including pH effects) fine-tune expression and adaptation, but they act on sequences that originate and diversify through mutational processes.

If a specific claim or paper shows otherwise, share it for review.

Review the facts from “Nutrient-dependent/pheromone-controlled adaptive evolution” my model (6/14/13) and/or Cellulose: A Plant Cell Biology Game (for ages 14+)

Carbon-hydrogen (C–H) bonds link subatomic particles called electrons to the foundation of organic chemistry. C-H bonds are the defining feature of hydrocarbons at the origin of oxygen-dependent carbon-based life ~6-10,000 years ago.

In C (carbon)-Alkylation, the alkyl group attaches to the carbon atom to yield an alkylated carbonyl compound, which is the thermodynamically stable favored product, because carbon-carbon ( C-C) bonds are more stable than carbon-oxygen (C-O) bonds. C-O can be broken by stress-linked changes in the potential of hydrogen (pH).

Stellar energy from a black hole 50 million times larger than the Earth’s sun links photosynthesis from C–H bonds and C-O bonds to C-alkylation, a naturally occurring process for the formation of carbon-carbon bonds in carbon-based life.
1) In my model, “Dietary medium-chain triacylglycerols in metabolic regulation” 6/1/26, and 2) “Overexpression of miR-219 as a potential therapeutic strategy of glioblastoma cells in vitro” link 3) UV light-activated fixation of carbon in cyanobacteria to the morphological and behavioral phenotypes of human populations from East Asia to North America via nutrient energy-dependent pheromone regulated biophysical constraints on gene-enzyme alkylation, and fixation of EDAR V370A in organized genomes during the past 6-10,000 years of ecological adaptations.
4) “Extracellular Vesicles in Regenerative Dentistry” 6/8/26, 5) Harvard’s patent for” RNA-guided human genome engineering,” and 6) Pfizer’s patent for pheromone regulated LH-dependent creation of stem cells and regeneration of neurons in the brain link 7) “Connecting the molecular function of microRNAs to cell differentiation dynamics” 9/25/19 across kingdoms via 8) sexual differentiation of yeast cells and 9) the African elephant model of cancer-free survival compared to 10) virus-driven extinction of Angel Trumpets in the wild.

In his 2/14/18 misrepresentation of facts about biophysically constrained energy-dependent cell type creation and differentiation across kingdoms: “A Conversation With George Church,” he claimed ” We found the enzymes that occur in nature, which was not obvious, and both companies have patents on making those alkanes.”
The fact that diet-driven enzyme-gene interactions naturally occur across kingdoms links Merian’s (1679) claims to Darwin’s (1859) claims about God’s “conditions of life” to energy-dependent enzyme-gene interactions sans moronic theories, masking algorithms, and/or claims about the discovery of non-obvious naturally occurring enzyme-gene interactions.

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” “The synthesis of RNA in isolated thymus nuclei is ATP dependent.” (1964) and Dobzhansky (1964) Biology, molecular and organismic
“The notion has gained some currency that the only worthwhile biology is molecular biology. All else is “bird watching” or “butterfly collecting.” Bird watching and butterfly collecting are occupations manifestly unworthy of serious scientists!” (p. 443)

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