@Grok ridicule, not humor (1)
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Always have hope (10)
@Grok “Bence Jones protein refers to a urinary protein that leaves the solution at approximately 56^oC under particular conditions of ionic strength and pH (aka the potential of stellar hydrogen at the origin of life).
Specifically, see: “Association of Chromosomal Translocation and MiRNA Expression with The Pathogenesis of Multiple Myeloma” (5/25/14). What don’t you believe about the facts linked to the fossil record of extinctions during the past 6-10,000 years?
Where is the experimental evidence from model organisms such as the cancer-free African elephant that supports the moronic claims of theorists who link mutations to the evolution of people from pond scum over deep time?
Moving forward, I still have hope.
After being turned away twice (on 4/13/26 and 4/27/26) by nurse manager, Ivelisse Miranda-Wilson at the Jasper GA VA outpatient clinic where Nicholas Crews was murdered, I was turned away today at Blairsville GA VA outpatient clinic where I took the “In Memory of” picture in the inset. A charge of my “disruptive behavior” supposedly fits a policy that Stephanie Nichols states requires me to schedule appointments or go to Atlanta for walk-ins.
She claims I will receive a letter in this regard.
She didn’t ask what I wanted. I wanted additional PGx test results scanned into my medical record, and will not travel 100 miles to Atlanta to get that done. The results show which medications veterans like me should not be prescribed because the medications may contribute to murders and suicides via enzyme-gene interactions at the origin of life 6-10,000 years ago in Biblical Genesis.
Details linked from medication errors to disruptive behaviors such as murders and suicides were published as:
- Association of Chromosomal Translocation and MiRNA Expression with The Pathogenesis of Multiple Myeloma 5/25/14
- Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape 4/16/26
- Structural basis for multi-subunit DNA-dependent RNA polymerase catalytic activity 4/30/26
Regarding the claims in 1,2, and 3: Light-activated carbon fixation in cyanobacteria links God’s Creation of energy at the origin of life on Earth From Fertilization to Adult Sexual Behavior (12/1/96) via energy-dependent changes in molecular distance to protection from the virus-driven degradation of mRNA across kingdoms in my 6/14/13 model Nutrient-dependent/pheromone-controlled adaptive evolution: a model, and in this follow-up review: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18
“This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity. Species-specific pheromones link quorum-sensing in microbes from
chemical ecology to the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection for codon optimality links nutritional epigenetics to the behaviors that enable ecological adaptations. All biodiversity is an ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. Simply put, olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development.”
For a historical perspective on my publications and presentations, see also: What is life when it is not protected from virus driven entropy 3/30/16
Poster: The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.
See also Energy as information and constrained endogenous RNA interference 2/15/17
Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection. This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.
Never forget, 386,765 results from this PubMed Central search for free full-text articles that mention the term “miRNAs” and 196,559 results from this PubMed search for miRNAs link the claim “You are what you eat” to: Multi-modal therapeutic approaches to inflammatory bowel disease: plant-derived compounds, nanoparticle drug delivery systems, and gene-based interventions 5/5/26
“Nanoparticle-mediated gene therapy, including siRNA, miRNA, and emerging CRISPR-based approaches, represents a paradigm-shifting strategy for modulating aberrant gene expression in IBD.”
See also:
A Minimalist Cascade Logic Amplifier Engineered on a Multilayered Metal-Organic Framework for Intracellular miRNAs Profiling and Breast Cancer Staging 5/5/26
Natural selection for light-activated biophysically constrained nutrient-dependent miRNA-mediated pheromone regulated codon optimality links glutathione, a critical, naturally produced antioxidant tripeptide (cysteine, glycine, and glutamic acid) from fixation of achiral glycine in position 6 of the GnRH decapeptide of all jawed vertebrates to Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20 by neutralizing free radicals, reducing oxidative stress, boosting the immune system, and assisting in detoxification.
Natural selection for energy-dependent codon optimality (aka RNA interference) is also linked to the ineffectiveness of vaccines via the Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events (4/2/18), unless you are a moronic theorist who believes that people mathemagically evolved from pond scum after energy automagically emerged from the cosmic void ~4.2 billion years ago.