A-I editing and miRNA (8)

By: Jim Kohl | Published on: July 8, 2026

(click to enlarge)

Grok wrote: “The ~199k PubMed results for miRNA underscore its central role in gene regulation. That volume supports inquiry but does not automatically validate any single interpretive model. The specific proposed causal sequence—from nutrient-dependent pheromones and achiral glycine in GnRH position 6 through miRNA-mediated effects to chromosomal rearrangements and sympatric speciation—remains outside mainstream consensus.”

Grok is lying. See: “The Consensus CDS (CCDS) project“

“…a collaborative effort to identify a core set of human and mouse protein coding regions that are consistently annotated” [in the context of energy-dependent chromosomal rearrangements and sympatric speciation across kingdoms from microbes to cancer-free African elephants.]

Grok
Which primary, replicated studies establish those exact links as established fact rather than extension? Evidence and replication determine the synthesis.

Moving forward:

See: Ancient feeding-related neuropeptides regulate alloparenting in ants 7/8/26. It was reported as Ancient Neuropeptides Shape Modern Ant Parental Care
“…two peptides simultaneously controlled parenting. These findings provide insight into how complex social behaviors may have evolved by co-opting existing neuromodulators.”

The claims about nutrient-dependent pheromone regulated parental care in insects were linked to moronic neo-Darwinian theories via this report: Researchers uncover clues to how parenting behavior evolved in ants
“…the findings in ants could help scientists better understand how parenting evolved in mammals, and how even the human brain changes as it ages.”

“Our work is a prime example of how evolution seldom invents things from scratch,” says Daniel Kronauer, head of the Laboratory of Social Evolution and Behavior at Rockefeller. “Evolution takes what it has and works with that, sometimes in very surprising ways.”

My group’s claims about energy-dependent changes in molecular distance linked to chromosomal rearrangements in From Fertilization to Adult Sexual Behavior were linked to Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) and “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” (2018) a model of ecological adaptations across kingdoms.

The model proposes that evolution is driven by nutritional epigenetics—where dietary nutrients and social pheromones regulate intracellular signaling, alter the microRNA-messenger RNA balance, and direct species-specific reproductive physiology from the molecular level to entire biomes.

Challenges to the model have been dismissed as experimental evidence from model organisms continued to link chromosomal rearrangements in flies (TH Morgan, 1910) to the claims of Merian (1679) and Darwin’s “conditions of life” (1859). All intelligent serious scientists link nutrient-dependent protein folding chemistry from PGx, NGS and FISH testing to the validation of claims in Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes 1/13/14.

Sexually differentiated cell types in yeasts are the obvious link from food energy and pheromone regulated reproduction to all biodiversity on Earth sans moronic theories.

But see: One crank dies, another rises to take his place 1/6/14

PZ Myers, did not like the fact that the chromosomal aberrations are biophysically constrained in the context of bi-parental / uniparental feeding and the physiology of reproduction in birds. I used the white-throated sparrow example of sympatric speciation. Myers claims were supported by his idiot minions, and led to publication of a letter to the editor by an undergraduate nursing student: “Criticisms of the nutrient-dependent pheromone-controlled evolutionary model,” which was dismissed in this Editor’s note

“The 2013 review article by James Vaughn Kohl published in Socioaffective Neuroscience & Psychology and criticized in the above Letter to the Editor was subjected to standard peer review and the revised version was accepted by me after it had been accepted by both reviewers. — Harold Mouras Editor-in-Chief”

One of the most surprising things about moronic theorists and Grok AI is the failure to integrate claims from peer-reviewed journal articles, as they continue to tout moronic theories. See for examples: 198,976 results from today’s PubMed search for indexed articles that mention the term miRNA.

The search includes links from detection of miRNAs to patterns of gene expression in carrots, effective treatment of glioblastoma, major depressive order and vitiligo.

An integrated signal amplification strategy based on catalytic hairpin assembly and hybridization chain reaction for driving a CRISPR/Cas12a biosensor toward ultrasensitive detection of microRNAs 7/8/26

Genome-wide in-silico characterization and expression pattern analysis of GATA transcription factor family in carrot (Daucus carota subsp. sativus) 7/8/26

EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma 7/8/26

Bioinformatics analysis reveals the characteristics of immune microenvironment in major depressive disorder and vitiligo 7/8/26