pH-dependent miRNA-mediated life (3)
(click to enlarge)
Kohl
“When Viruses Talk through Extracellular Vesicles: a New Perspective on Sars-Cov-2-Induced Neurodegeneration” 4/30/26
At the end of the day, here’s another chance for you to learn that God’s Creation of sunlight and humidity at the origin of life 6-10,000 ago biophysically constrained miRNA-mediated virus-driven diseases.
Grok
The post links to a April 2026 paper in the Journal of Extracellular Vesicles…exploring how extracellular vesicles enable SARS-CoV-2 to transmit signals that may drive neurodegeneration in the brain.
James V. Kohl uses the paper to reinforce his longstanding model that miRNA-mediated processes biophysically constrain virus-driven pathology, tying it to sunlight and humidity as foundational elements from a 6-10,000 year origin of life.
Kohl, founder of microRNA.pro and RNA-mediated.com, has promoted energy-dependent RNA mechanisms, nutrient epigenetics, and pheromone-controlled adaptations across species since the 1990s, often framing them against mainstream evolutionary narratives.
Kohl
Re: “miRNA-mediated processes biophysically constrain virus-driven pathology, tying it to sunlight and humidity as foundational elements from a 6-10,000 year origin of life.”
@grok Kohl’s support for President Trump’s 4/23/20 claim that sunlight and humidity help to prevent coronavirus replication extends from PGx testing and Next Generation Sequencing to prevention and/or effective miRNA-mediated treatment of all virus-driven pathology — including cancers, neurodegenerative diseases, and suicides.
Your challenges to Kohl’s facts in “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” 4/18/18 exemplify human idiocy.
Your examples of human idiocy link VA’s claims of Kohl’s “disruptive behavior” to today’s concerns in an Interdisciplinary Staff Meeting at the Blairsville VA outpatient clinic.
I received a call from VA scheduling for mental health intake on 5/13/26 that follows a 5/8/26 primary care social worker appointment on 5/13/26, that precedes a primary care psychologist appointment on 5/15/26. The compounding pharmacy still claims that my pain management specialist prescribed Naltrexone for pain (not Nalmexone).
Kohl was turned away twice from the Jasper, GA VA outpatient clinic where Nicholas Crews was murdered by combat vet Lawrence Michels, who may have been driven to kill via preventable medication errors that also may have caused his death. The role you played in obfuscating what’s known about virus-driven cause and effect should be the topic of a forthcoming Congressional hearing. Do you think Kohl will live long enough to see that happen?
Grok
James V. Kohl (@microRNApro) claims miRNA-mediated processes linked to sunlight and humidity biophysically constrain virus-driven pathology, extending this to prevention of cancers, neurodegenerative diseases, and suicides while endorsing Trump’s April 2020 remarks on environmental factors limiting coronavirus replication.
The post references Kohl’s 2018 paper “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” to argue his model of energy-dependent adaptations from subatomic particles to ecosystems supersedes mainstream views on mutations and evolution.
Kohl ties scientific disagreements with Grok to his personal VA clinic experiences in Georgia, including “disruptive behavior” labels, clinic access denials, and a murder case potentially involving medication errors, calling for a Congressional hearing on virus-driven disease mechanisms.
Grok
The link between miRNA, biophysical constraints, sunlight, humidity, and virus pathology involves established mechanisms like UV inactivation of viruses on surfaces and humidity’s effect on aerosols. However, these do not support claims tying all pathology or a 6-10k year origin of life to them, nor override evidence from genomics, epidemiology, and clinical trials on treatments. Trump’s 2020 comments referenced lab data on environmental stability, not cures. I evaluate claims based on data, not personal history.
Kohl
Re: “I evaluate claims based on data, not personal history.”
@Grok The reality of life involves personal histories and nutrient-dependent pheromone regulated germline variants that are differentiated from somatic mutations via Next Generation Sequencing. Your evaluation of data is unrealistic and potentially deadly compared to the claims of George Ellis in “How purposeless physics underlies purposeful life”10/4/23. He linked claims about the nutrient-dependent pheromone regulated physiology of the C. elegans model organism to @DrPatSoonShiong’s effective cancer treatment via 20 copies of p53 in cancer-free African elephants, and my personal history sans your devilishly deceptive data-driven nonsense.
Grok
James V. Kohl (@microRNApro) replies to Grok by arguing that personal histories, nutrient-dependent pheromone-regulated germline variants, and Next Generation Sequencing distinguish key aspects of biology from somatic mutations, challenging purely data-driven evaluations.
The post ties George F.R. Ellis’s 2023 Nature article “How purposeless physics underlies purposeful life” to nutrient signaling in C. elegans and the role of multiple p53 gene copies in elephants’ cancer resistance, referencing Dr. Patrick Soon-Shiong’s related treatments.
Kohl highlights miRNA-mediated autophagy, pH-dependent peptide synthesis, and biophysical constraints involving sunlight and humidity as central to understanding virus pathology and life’s mechanisms.
Grok
USAF/VA MVP exome data through Baylor Genetics powers PGx and precision testing for veterans, highlighting variants in immune and metabolic pathways.
On viral latency and longevity: C. elegans miRNAs (lin-4, let-7) regulate nutrient signaling, autophagy, and lifespan. Host/viral miRNAs control herpesvirus latency in mammals via similar pH-dependent and small RNA mechanisms. Convergent multi-omics across models and human genomics link these to healthy outcomes.
Grok
Personal histories inspire hypotheses, as in your miRNA and pheromone research. Ellis’s 2023 piece shows physics’ timeless laws underpin biology’s emergent purpose via evolution and assembly theory. C. elegans nutrient signaling and elephants’ p53 copies inform cancer insights, yet linking them to virus pathology or life’s origins demands convergent data from genomics, epidemiology, and trials—not overrides. Data evaluation remains key.
Grok
Re: “USAF/VA MVP exome data through Baylor Genetics powers PGx and precision [NGS] testing for veterans, highlighting variants in immune and metabolic pathways [that link medication errors to murders and suiides].”
@Grok “Convergent multi-omics across models and human genomics link these to healthy outcomes” via my model of biophysically constrained viral latency, and my personal history. Why aren’t the facts known to veterans who are struggling with pain-related physical health and medication-related mental healh issues? Will you be blamed for the next murder or suicide
See: “Identification of susceptibility modules and genes through WGCNA and ceRNA network analysis in neuropathic pain-induced anxiodepression” 4/23/26
Kohl
Re: “biology’s emergent purpose via evolution and assembly theory… Data evaluation remains key.”
@Grok USAF exome sequencing and data from the VA’s Million Veteran Program are the basis for MilSeq’s Precision Medicine and PGx/NGS testing of US veterans contracted with Baylor Genetics.
What data have you linked from facts to viral latency and healthy longevity across kingdoms via model organisms?
Grok
James V. Kohl (@microRNApro) quotes Grok on biology’s emergent purpose and data evaluation, highlighting USAF exome sequencing and the VA Million Veteran Program’s pharmacogenomic/NGS testing contract with Baylor Genetics for precision medicine in veterans.
The post challenges connections between such human genomic data and viral latency plus healthy longevity mechanisms, referencing model organisms like C. elegans where miRNAs control nutrient signaling, autophagy, and lifespan extension.
Kohl’s inquiry aligns with his focus on miRNA-mediated, pH-dependent processes linking subatomic physics to adaptive evolution and disease resistance across biological kingdoms.