Always have hope (7)

By: Jim Kohl | Published on: May 4, 2026

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Grok
Thanks for the correction—Ellis does reference C. elegans as a potential model to explore these ideas further in his 2023 piece.

Your diagram lays out an interesting proposed framework linking miRNA, pH-dependent chemistry, autophagy, feedback loops, and stress/mutations.

The core question stands: has this specific chain been experimentally shown to drive sympatric speciation in a natural population (in C. elegans or elsewhere)? If so, links to the primary papers would be helpful.

See George F.R. Ellis and Jonathan Kopel: The Dynamical Emergence of Biology From Physics: Branching Causation via Biomolecules 1/24/19, my published works from 1996-2018, and 196,450 results from today’s PubMed search for indexed articles that mention the term ‘miRNAs.”

Had he not been a biologically uninformed theorist, Stephen Hawking could have followed the lead of George FR Ellis co-author of Hawking’s The Large Scale Structure of Space-Time (1973). Ellis could have helped Hawing and other theorists link miRNAs to effective treatment of amyotrophic lateral sclerosis and all other virus-driven diseases.

Grok, although you are nothing more than a stupid bot, you could help establish the facts about virus-driven diseases via a PubMed search for: mirnas and “amyotrophic lateral sclerosis” 543 results.

See: Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity 4/1/19.

“Using Drosophila as a model, we have validated that the C9orf72 hexanucleotide repeat expansion products could lead to the accumulation of the NMD substrates and identified arginine-rich dipeptide repeats, including poly glycine-arginine and poly proline-arginine, as the main culprits of NMD inhibition. Furthermore, in human SH-SY5Y neuroblastoma cells and in mouse brains, expression of glycine-arginine with 36 repeats (GR36) was sufficient to cause NMD inhibition.”

Never forget, achiral glycine in position 6 of the GnRH decapetide has been linked to the footprints of life and all biophysically constrained biodiversity in jawed vertebrates during the past 6-10,000 years of ecological adaptations in my model of God’s energy-dependent miRNA-mediated autophagy.

Because moronic theorists have no model for comparison, see also:

C9orf72 and autophagy and mirnas 1,376 results

Example: The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy

Example: Small RNA sequencing identifies serum tDR-1:34-Gly-GCC tiRNA levels as a biomarker for survival in amyotrophic lateral sclerosis

Example: MicroRNA profiling in post-mortem spinal cord of C9ORF72-related ALS patients reveals molecular pathways involved in motor neuron degeneration

Modulation of the miR-485-3p/PGC-1α Pathway by ASO-Loaded Nanoparticles Attenuates ALS Pathogenesis

and NAD⁺‒circadian rhythm coupling in dementia 5/1/26