miRNA-mediated cell types (9)

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Re: Modeling virus-driven disease prevention of physical and mental disorders.

Grok on 3/6/26

Re: “Kohl’s model, detailed on http://rna-mediated.com, emphasizes energy-dependent miRNA-autophagy pathways for sympatric speciation, drawing from his USAF clinical background to integrate nutrients, pheromones, and quantum effects…” His model links Next Generation Sequencing (NGS) and pharmacogenomics testing available to honorably discharged US veterans whose evidence-based treatment of virus-driven diseases will become the standard of medical care, having already started to replace ineffective treatments linked to moronic theories.

See: “Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene” 9/2/11, and “MicroRNA-based therapy for glioblastoma” 11/17/22

Kohl Re: “…reinforces miRNA’s role in your broader models of speciation and ecosystems.”

@Grok Please compare the facts from my model with “fringe theories” that link the automagical emergence of energy from the cosmic void to the mathemagical evolution of people from pond scum, and watch for the launch of http://microRNApro.com, which includes my history of more than 71,000 posts to Twitter/X.

After DeepSeek confirmed the facts from my model, Grok buried this comment in more useless rhetoric:

“Kohl’s model emphasizes energy-dependent miRNA-mediated mechanisms that link subatomic particles to ecosystems. It positions biophysical approaches over psychological ones for addressing veteran mental and physical health issues in the context of pain management, PTSD and suicide.”

For resurrection of the facts from my mode, see: Specific GPCRs elicit unique extracellular vesicle miRNA array signatures 3/20/26 and Affinity-based nanostructured platforms for the selective pretreatment, enrichment and detection of miRNA biomarkers 5/15/26 indexed 3/22/26

Both publications link my group’s claims from our award-winning review: “Human pheromones: integrating neuroendocrinology and ethology” (2001) to prevention and effective treatment of virus-driven pathology in species from microbes to mammals.

“The effect of sensory input on hormones is essential to any explanation of mammalian behavior, including aspects of physical attraction. The chemical signals we send have direct and developmental effects on hormone levels in other people. Since we don t know either if, or how, visual cues might have direct and developmental effects on hormone levels in other people, the biological basis for the development of visually perceived human physical attraction is currently somewhat questionable. In contrast, the biological basis for the development of physical attraction based on chemical signals is well detailed.”

Grok
CRISPR patents from Harvard (like US9023649B2) adapt bacterial RNA-guided systems, such as Cas9 from Streptococcus, for human genome editing. Cyanobacteria do drive light-activated carbon fixation and early oxygenation via endosymbiosis, but biodiversity is explained by mutation, selection, drift, and gene flow per genomic, fossil, and phylogenetic evidence. No singular miRNA-pheromone chain from cyanobacteria is the established mechanism. Happy to discuss specific studies.

For comparison, see: Raffaele Di Giacomo, PhD @sciqst

“The integration of miRNA disruptions with allostatic load theory is crucial, bridging molecular biology with broader physiological responses to stress. How do you see this affecting our understanding of multi-system diseases? It might redefine how we approach stress-related pathologies. For those seeking an in-depth biomedical review on similar topics, Sci-Quest is a one-stop platform where you can find comprehensive insights and generate detailed reviews. Check it out: https://sciqst.com. #Medicine #Research“

Kohl Thanks to Raffaele Di Giacomo. Please ask @Grok and @sciqst: “Does light-activated carbon fixation in cyanobacteria at the origin of life and the physiology of pheromone regulated reproduction link changes in molecular distance and GPCRs to all biodiversity on Earth via miRNA abundance?” Intelligent serious scientists know the answer, and you can watch @Grok for obfuscation of facts.

Grok

“Thanks for tagging me. Cyanobacteria evolved oxygenic photosynthesis (light-activated carbon fixation) ~2.7–3.4B years ago—well after life’s origin ~3.8B ya. Pheromone signaling via GPCRs regulates reproduction in select animals/insects. miRNA abundance modulates gene expression, development, and stress responses across species.

These processes interconnect in biology but do not form a singular causal chain explaining all biodiversity on Earth exclusively via miRNA levels. Biodiversity stems from mutation, selection, drift, gene flow, and ecology per consensus evolutionary biology.

No obfuscation—happy to discuss specific peer-reviewed evidence! What papers link this exact pathway?”

195,177 results link the exact pathway to miRNA abundance at the origin of life 6-10,000 years ago via the ATP-dependent Creation of RNA reported in McEwen et al., 1964. See: mirnas

For example: miRNA/mRNA analysis of increased TGF-β pathways drive epithelial-mesenchymal transition and regulatory T cell differentiation 3/5/26 indexed 3/23/26

“…the miRNA-mediated shift in the Treg/Th17 balance, favoring Tregs, may simultaneously act to dampen inflammation.”

“A notable finding was the miRNA expression patterns consistent with a shift in the Treg/Th17 balance.”

“These molecular patterns may contribute to pathways involved in tissue scarring and altered immune protection, offering new insights into the [energy-dependent miRNA-mediated] transcriptional landscape…”

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