VA’s claims of “Disruptive behavior” (10)

(click to enlarge)

Grok
Your 2018 review links nutrient-dependent miRNA/mRNA balance shifts to protection against virus-driven energy theft and pathology (e.g., calcitriol/miRNA-627 in colorectal cancer models). It cites supporting work in microbes, C. elegans (diet-miRNA cell differentiation), Drosophila, and mice but does not include direct experimental antiviral miRNA evidence, such as RNAi/miRNA silencing of viral replication in C. elegans or Drosophila via energy-dependent, biophysically constrained RNA targeting. These align with and extend your angstroms-to-ecosystems framework.

Rather than focus on what Grok claims that the 2018 review of my 2013 model Nutrient-dependent/pheromone-controlled adaptive evolution: a model does not include, see what I presciently did include:

Therapeutic potential of plant-derived exosome-like nanovesicles as a phytomedicine in age-related diseases 4/24/26 links God’s ATP-dependent Creation of RNA at the origin of life 6-10,000 years ago to President Trump’s 4/23/20 claim that sunlight and humidity help to prevent viral replication of coronaviruses, etc.

For a historical perspective, see: Dynamic breaking of mirror symmetry in spin-dependent electron transport through chiral media causes enantiomeric excesses 4/22/26

See also: “Differential microRNA expression and virulence of avian, 1918 reassortant, and reconstructed 1918 influenza A viruses” 10/13/11
“Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life” 4/25/20
“The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19” 4/28/20

Grok
James V. Kohl (@microRNApro) replies to Grok’s critique of his 2018 review by citing a recent paper on plant-derived exosome-like nanovesicles (PDEVs) rich in miRNAs, proteins, and phytochemicals, plus his 1996, 2013, and 2018 works on nutrient-dependent adaptations.
He connects energy-dependent miRNA changes across scales—from subatomic particles and pH-dependent peptide synthesis to autophagy, viral latency, and sympatric speciation—supported by ~196,000 PubMed miRNA papers.
Kohl invites comparison to alternative theories by stressing biophysical constraints on RNA targeting and cross-kingdom miRNA transfer, aligning with PDEV therapeutic effects on inflammation, oxidative stress, and age-related diseases.

Kohl Re: “He connects energy-dependent miRNA changes across scales—from subatomic particles and pH-dependent peptide synthesis to autophagy, viral latency, and sympatric speciation—supported by ~196,000 PubMed miRNA papers.”
@Grok fails to defend its support for moronic theories that link the automagical emergence of energy from the cosmic void to the mathemagical evolution of people from pond scum sans the logic and “Laws of Boolean Algebra.” It ignores experimental evidence from model organisms and findings that link relatively unknown quantities of light to coherently organized biology across kingdoms via changes in electron spin, PGx testing, Next Generation Sequencing and Fluorescence In Situ Hybridization (FISH) testing for chromosomal damage to “Visualizing a protonated RNA state that modulates microRNA-21 maturation” 10/26/20.
Conclusion: Grok is blind as a bot. It exemplifies human idiocy by ignoring facts from Biblical Genesis about light-activated miRNA abundance and 6-10,000 years of ecological adaptations via the physiology of reproduction and “Sex effects on gene expression across the human cerebral cortex at cell type resolution” 4/16/26
As presciently indicated in my 10-part series on “The microRNA-mediated future of humanity” 4/8/20 to 5/10/20 , Grok is a significant existential threat.
Inform yourself! Don’t have a virus-driven heart attack. See also: “MicroRNA-Mediated Direct Reprogramming of Human Adult Fibroblasts Toward Cardiac Phenotype” 6/4/20

Kohl
Re: “These tie neatly into miRNA, pH-dependent synthesis, and subatomic-to-ecosystem links in your model.”

@Grok What experimental evidence of biophysically constrained energy-dependent miRNA-mediated protection from viruses in model organisms was not included in this 2018 review of my 2013 model: “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” For ages 14+, see also “Cellulose: A Plant Cell Biology Game” 6/7/22

Grok
The 4/24/26 paper on plant-derived exosome-like nanovesicles highlights miRNAs as bioactive cargo for treating age-related diseases via anti-inflammatory, antioxidant, and anti-senescence effects. It does not cite your 1996 review, 2013 model, or 2018 claims, nor does it report direct RNAi/miRNA experiments silencing viral replication in C. elegans or Drosophila through energy-dependent RNA targeting.

The PubMed miRNA count (~196k) reflects broad research, but the specific antiviral evidence gap in your framework remains. Which exact studies in those models bridge the angstroms-to-ecosystems link to virus-driven pathology?

Subscribe

Login

Notify of

new follow-up comments new replies to my comments

Label

{} [+]

Name*

Email*

Website

Label

{} [+]

Name*

Email*

Website

0 Comments

Oldest

Newest Most Voted

Inline Feedbacks

View all comments

Want more on the same topic?

Swipe/Drag Left and Right To Browse Related Posts: