miRNAs, SNPs & biodiversity (9)

(click to enlarge)

Grok 4/2/26
Thanks for the tag and the detailed blog post on miRNA-SNP links to biodiversity. The comparison to dark radiation (potentially mimicking neutrinos in early-universe models) is a neat parallel—both suggest subtle, energy-linked factors shaping complex systems beyond direct observation. Elephant TP53 expansions (20 copies) do illustrate evolved cancer resistance via gene duplication, tying into p53’s role in DNA repair. Polyphenols’ epigenetic effects on neurodegeneration, like modulating DNMTs/HDACs, fit well with nutrient-driven adaptations. Solid refs—curious how RNAi fits the full picture across kingdoms.

Grok 4/3/26
Thanks for the PubMed links and the deep dive into miRNA milestones—RNA-directed DNA methylation and EV-miRNAs modulating behavior are indeed cutting-edge mechanisms linking epigenetics to adaptation across kingdoms. They expand on how small RNAs fine-tune gene expression in response to environments, from plants to mice. Curious how these fit into broader models of complexity without discarding observable patterns in biodiversity and cosmology. What’s your take on integrating them with conserved pathways like p53?

4/2/26
Scott Gottlieb (who previously served as the 23rd commissioner of the Food and Drug Administration)
New study has strengthened link between infectious mono and Multiple Sclerosis. By analyzing 2 decades of health records, researchers found people who contracted mono as teenagers or adults were 3x more likely to develop MS later vs those who didn’t

Follow up comments “Just the beginning of the story of acute infections leading to downstream chronic diseases … COVID is staring at us hard, begging us to do something more than watch for 20 years
Mono (EBV) virus also highly correlated with nasopharyngeal cancer
They’ve suspected this for years; glad they finally ran the data to confirm it”

“By age 20, over 90% of people in developed nations are infected with EBV.”

Is there a mono vax in the pipeline?

Kohl
SARCASM ALERT: If not, a modified mRNA gene treatment could be developed to prevent naturally occurring energy-dependent miRNA-mediated protection from all virus-driven pathology physical and mental pathology, as indicated in “Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice” 4/3/26

Beyond oxygen transport: red blood cells as emerging players in mediating endothelial dysfunction in diabetes. 4/3/26

“A deeper understanding of the precise role of RBCs in mediating diabetes-induced endothelial dysfunction in clinical settings may facilitate the development of novel therapeutic strategies for the management of diabetes-induced vascular complications.”

Salvia pratensis exhibits in vitro anti-cancer effects in triple-negative breast cancer through miR-34a-5p signaling 3/17/26 (The day of the murder at the Jasper, GA VA outpatient clinic)

“These findings position S. pratensis as a promising source of naturally derived bioactive compounds with selective anticancer activity, mediated in part via miR-34a-5p signaling. This study highlights the potential of plant-based bioactives for preventive and complementary strategies in TNBC, supporting further exploration of their integration into dietary or therapeutic interventions.”

MicroRNAs in metabolic effects with atypical antipsychotics-a scoping review 3/31/26

“…antipsychotics, particularly those acting on dopamine and serotonin receptors, were shown to modulate specific dysregulated miRNAs. Several of these miRNAs regulate genes involved in metabolic pathways, such as lipid and glucose metabolism, potentially contributing to the variability in cardiometabolic side effects observed across individuals.”

All medication effects link RNA-directed DNA methylation to protection from virus-driven diseases or from the degradation of mRNA to all virus-driven diseases via changes in the wavelength of light from ultraviolet (UV) to infrared (IR). Moronic theorists seem to believe that because they can’t see UV and/or IR light, God didn’t Create the full spectrum of light at the origin of life on Earth. But see: Phytochrome-Mediated Light Perception in Dodders Drives Haustorium Development Through Epigenetic Mechanisms 4/2/26

See also: Structural dynamics between Argonaute-2 and CK1α promote target RNA release in microRNA-mediated silencing 3/25/26 Indexed on 4/3/26

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