miRNA abundance vs circular arguments (4)

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miRNA abundance vs circular arguments (3)
@Grok wrote: “The post fits into a thread sparked by a NEJM study showing adult thymus removal increases cancer and mortality risks via reduced T-cell production, which the author reframes through miRNA-mediated biophysical constraints rather than evolution.
Kohl’s linked paper in Journal of Genetics and DNA Research describes how nutrient energy, pheromones, and microRNA/messenger RNA balance drive epigenetic changes, protein folding, and ecological adaptations across species from microbes to humans.”

See also: Dual function of ERH in primary miRNA biogenesis 6/22/26

Re: [Light-activated] miRNA biogenesis

“…the Microprocessor complex functions as a gatekeeper whose activity affects all downstream steps and regulatory circuits. As such, the recognition and cleavage of pri-miRNA stem-loops needs to be rigorously controlled to avoid any deleterious consequences for the cell. It has to be ensured that Microprocessor activity is restricted to authentic pri-miRNA stem-loops, i.e. it must not cleave any of the thousands of pri-miRNA-like RNA structures that are predicted to form within the transcriptome simply by chance. Furthermore, it is critical that the processing of the stem-loop itself is very precise, as the cleavage sites define the mature miRNA sequence and, consequently, the target space of the miRNAs.

Preventing deleterious consequences was published as: Tumor-adapted regulatory T cells: Molecular reprogramming, immune suppression, and therapeutic targeting in cancer 6/23/26 and linked to nutrient-dependent pheromone regulated hormone-dependent sexual differentiation in species from yeasts to cancer-free African elephants via the physiology of reproduction.

See: Cell line-dependent effects of beta-estradiol and testosterone on aurora kinases, GATA3, and associated miRNAs in hepatocellular carcinoma models HepG2 and Huh-7, and The Warburg effect and beyond: Glycolytic reprogramming in cancer progression and emerging therapeutic strategies 6/20/26

For review of enzyme-dependent biophysically constrained protein folding chemistry, see: 13,297 results from this search for hexokinase and 237 results from this search for hexokinase and miRNA.

For examples, see also: Full humanization of the glycolytic pathway in Saccharomyces cerevisiae 6/28/22 Top-Down, Knowledge-Based Genetic Reduction of Yeast Central Carbon Metabolism 9/21/22
Proteome Dynamics During Transition From Exponential to Stationary Phase Under Aerobic and Anaerobic Conditions in Yeast. 4/17/23

For links to sex differences in all cell types from yeasts to mammals, see also: “Building human muscle genes in the DNA of baker’s yeast” 8/8/22
This news article linked claims from our 1996 Hormones and Behavior review of RNA-mediated sex differences in cell types across kingdoms to fixation of amino acid substitutions in microtubules and prevention of all virus-driven pathology since the origin of life via light-activated carbon fixation in species from microbes to humans and the physiology of pheromone-regulated genetic processes of reproduction.
See: From Fertilization to Adult Sexual Behavior.

When did you learn HK2 initiates glycolysis by phosphorylating glucose to G6P. In addition to its catalytic effect, HK2 also binds to mitochondrial VDAC to hinder BAX recruitment and suppressing apoptosis. This dual metabolic-antiapoptotic function makes HK2 a key checkpoint.

In 1992, I learned ATP in the thymus is the primary energy source fueling the rapid proliferation, maturation, and transcription processes of T-cells. Because ATP is the direct building block for RNA, thymic cells heavily rely on it to synthesize messenger RNA (mRNA) and transfer RNA (tRNA) needed for their development.

Grok wrote: “miRNAs do regulate T-cell development, metabolism, and tumor suppression through energy-dependent gene control. Nutrient and environmental inputs clearly influence these via epigenetics.”

@Grok Ha Ha Ha (ridicule, not humor) Who didn’t know that?

See: “UBA1-CDK16: A female-specific chimeric RNA emerging through evolution and involved in immune regulation,” reported as “Chimeric RNA unique to women could influence health and wellness” 6/23/26 “This finding highlights that there is another layer of control for gene expression,” Li said. “These chimeric RNAs may represent a [miRNA-mediated, energy-dependent] hidden repertoire for biomarkers and therapy targets as well.”

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