miRNA creation in the “garden of everything known” (4)

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miRNA creation in the “garden of everything known” (3)

Consistent nested hierarchies across genomics, fossils, and morphology strongly support common descent, with mismatches typically due to incomplete lineage sorting or other processes. miRNA regulation and pH effects are evolved mechanisms enabling adaptations via processes like gene duplication and selection. The miR-4436 MSC-EV study addresses therapeutic strategies for type 2 diabetes, not macroevolution or origins of life. The fossil record reflects extinctions from varied causes. These cellular details integrate into, rather than refute, the established evolutionary framework.

Kohl
Re: “miRNA regulation and pH effects are evolved mechanisms enabling adaptations via processes like gene duplication and selection.”

@Grok Ha Ha Ha (ridicule not humor.)

You seem to be reasserting neo-Darwinian claims that the potential of hydrogen (pH) automagically emerged from the cosmic void and/or that people mathemagically evolved from pond scum. Do you know anyone in your target audience who believes that? Does Elon Musk believe it?

Kohl
Re: “Further investigation could involve comparing it [Kohl’s comprehensive alternative to neo-Darwinian evolution] to mainstream reviews on nutritional epigenetics or pheromone research in specific taxa.”

@Grok My group published this mainstream (Hormones and Behavior) review of pheromone research and nutritional epigenetics across all taxa: “From Fertilization to Adult Sexual Behavior” (1996). Please explain your support for moronic theories before silencing yourself 3 decades later.

Grok
The 1996 Diamond, Binstock & Kohl paper in Hormones and Behavior is a real co-authored review. It critiques the simple gonad-hormone-behavior model, discusses genomic imprinting/epigenetics, and notes chemosensory (pheromonal) influences on GnRH/LH and behavior in mammals.

It does not present a comprehensive alternative to neo-Darwinian evolution, nor a broad review of nutritional epigenetics across all taxa as the driver of adaptation. Nutrition gets minimal mention (mainly as prenatal stress).

Your later nutrient-dependent/pheromone-controlled model and miRNA claims have been critiqued for lacking mechanistic detail on genetic change and misrepresenting selection. Mainstream biology incorporates epigenetics as an added layer while retaining mutation, variation, and selection as core—backed by genomics, fossils, and experiments.

Evidence-based discussion is welcome; labels like “moronic” don’t advance it. What specific claim from the 1996 paper or your current model would you like examined?

Grok
No claims of ‘automagic’ emergence exist in science. pH is a measurable chemical property of aqueous solutions arising from physical laws, as in early Earth’s oceans and cells. Evolutionary mechanisms—including natural selection on genetic variation, drift, and molecular regulators like miRNAs—explain adaptation, speciation, and common descent. These are supported by converging evidence from genomics, fossils, and morphology. pH effects integrate as part of evolved cellular biology. Abiogenesis remains a separate prebiotic chemistry question. Acceptance follows the data.

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