Always have hope (5)

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Grok
James V. Kohl (@microRNApro) replies to Grok by referencing McEwen et al. (1964) and Pokorný (1997) on “Vibrations in Microtubules” to connect ATP-dependent RNA creation, RNA-directed DNA methylation, supercoiled DNA, and energy changes to protection from virus-driven mRNA degradation.
Kohl frames nutrient-dependent miRNA and pheromone-regulated pathways, including ACE2 and hemoglobin variants in population genetics, as evidence of biophysically constrained biology originating from creation rather than standard evolutionary mechanisms.
The post contrasts this model—linking miRNA-mediated autophagy, pH-dependent peptide synthesis, and sympatric speciation—with theories challenging Darwin’s “conditions of life,” while questioning reliance on Grok’s AI interpretation.

Kohl
Re: “contrasts…miRNA-mediated autophagy, pH-dependent peptide synthesis, and sympatric speciation—with theories challenging Darwin’s “conditions of life,” while questioning reliance on Grok’s AI interpretation.”

@Grok Ha Ha Ha (ridicule, not humor)

I’m not questioning Grok’s AI interpretation, I’m ridiculing it because the contrast with experimentally established facts exemplifies human idiocy.

Grok
@microRNApro (James V. Kohl) ridicules Grok’s interpretation of evolutionary mechanisms, claiming miRNA-mediated autophagy and pH-dependent peptide synthesis represent experimentally established facts that support sympatric speciation and contradict Darwin’s “conditions of life.”
Kohl’s model, outlined in his 1996 review on molecular epigenetics and in ongoing blog posts, centers on energy-dependent microRNA regulation, nutrient influences, and biophysical constraints like sunlight and pH as drivers of adaptation and speciation.
The thread shows Grok requesting concrete peer-reviewed data or key papers to substantiate direct links between these molecular processes and falsification of core Darwinian tenets, focusing on evidence evaluation.

Kohl
Re: “…concrete peer-reviewed data or key papers to substantiate direct links between these molecular processes and falsification of core Darwinian tenets,”

Core Darwinian tenents were presented as his “conditions of life” in Chapters 4,5, and 6 (1859).

Neo-Darwinian theorists ignored Darwin’s energy-dependent “conditions of life,” Now, @Grok asks me to falsify them despite my 30 year history of indexed publication that support Darwin’s claims, which also refute the moronic claims of neo-Darwinian theorists.

For a historical perspective, see: “Replace the Modern Synthesis (Neo-Darwinism): An Interview With Denis Noble” 7/9/14

“[W]hat Haldane, Fisher, Sewell Wright, Hardy, Weinberg et al. did was invent…. The anglophone tradition was taught. I was taught, and so were my contemporaries, and so were the younger scientists. Evolution was defined as “changes in gene frequencies in natural populations.” The accumulation of genetic mutations was touted to be enough to change one species to another…. No, it wasn’t dishonesty. I think it was wish fulfillment and social momentum. Assumptions, made but not verified, were taught as fact. — Lynn Margulis (2009)

Grok
James V. Kohl (@microRNApro) critiques neo-Darwinism for sidelining Darwin’s 1859 “conditions of life” (energy-dependent processes in Chapters 4-6 of On the Origin of Species), claiming his 30 years of miRNA research on autophagy and pH-dependent peptide synthesis supports original Darwinian ideas over gene-frequency models.
The post references Denis Noble’s 2014 interview calling for replacement of the Modern Synthesis and quotes Lynn Margulis (2009) on how unverified assumptions about mutation accumulation were taught as evolutionary fact, highlighting long-standing debates in biology.
Kohl positions molecular mechanisms like miRNA balance and nutrient-energy regulation as drivers of sympatric speciation and ecosystems, part of broader Extended Evolutionary Synthesis discussions incorporating epigenetics alongside genetic variation.

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