@Grok ridicule, not humor (5)

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Minimum amino acid residues of an α-helical peptide leading to lipid nanodisc formation 10/21/14 links God’s ATP-dependent Creation of RNA at the origin of life 6-10,000 years ago to all biophysically constrained biodiversity on Earth via energy-dependent miRNA abundance and miRNA-mediated site-specific base modifications reported as:

Hydrophilic interaction chromatography and tandem mass spectrometry for the characterization of methylated oligoribonucleotides (Indexed 5/7/26)

“Taken together, the HILIC-MS/MS workflow proposes a robust method for simultaneous assessment of sequence integrity, impurities and site-specific base modifications, within a run time lower than 20 min. Altogether, this integrated HILIC-MS/MS strategy demonstrates the analytical power of HILIC applied to comprehensive characterization of miRNA and opens new perspectives for its application to biological samples, such as plasma and serum.”

Comprehensive characterization of energy-dependent miRNA-mediated changes in base pairs links God’s Creation of stellar hydrogen and water to biophysically constrained viral latency across kingdoms via the pH-dependent physiology of reproduction, RNA-directed DNA methylation (aka RNA interference/RNAi) and differences in the gene-enzyme interactions reported in PGx testing, Next Generation Sequencing, and chromosomal rearrangements via FISH testing.

Taken together, current technology allows the visualization of every energy-dependent link to healthy longevity across kingdoms, and every link from the virus-driven degradation of mRNA to mental and/or physical pathology. Test results are linked to the practice of precision medicine via “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” 4/18/18

“This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experiencedependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity. Species-specific pheromones link quorum-sensing in microbes from chemical ecology to the physiology of reproduction. The reciprocal relationships of species-typical nutrientdependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection for codon optimality links nutritional epigenetics to the behaviors that enable ecological adaptations. All biodiversity is an ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. Simply put, olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development.”

For a historical perspective, see my group’s review of energy-dependent changes in molecular distance across species: From Fertilization to Adult Sexual Behavior (12/1/96) and From traits to trajectories: development, agency and a phenotypic gap in demography 2/24/26

“A development-centric perspective champions an ‘unflattened’ framework that restores development, feedback, and behavior to demographic causation, revealing the organism as a developmental system—as the causal unit of selection.”

The developmental system as a causal unit of selection contrasts with the claims of all moronic theorists. I reiterate: energy-dependent development-centric perspectives eliminate moronic neo-Darwinian theories from any further consideration, whatsoever. Only moronic theorists and stupid bots such as Grok will continue to tout claims that energy automagically emerged from the cosmic void and/or that people mathemagically evolved from pond scum.

For proof of the development-centric perspective compared to mutation-driven evolution, see today’s PubMed search for indexed articles that mention the term “miRNAs.” Compared to an attempt to change the term “miRNAs” to 22-mers (28 results).

The attempt appears to have failed when light-activated miRNA abundance at the origin of life was linked to Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19 (2022) via the claim that “Findings from this pilot study may inform development of diagnostics, vaccines, and therapeutic antibodies, and provide insight into viral pathogenic mechanisms.”

Energy-dependent differences in the gene-enzyme interactions reported in PGx testing, Next Generation Sequencing, and chromosomal rearrangements via FISH testing present facts that are not likely to be successfully challenged by moronic theorists or stupid bots.

For comparison, I asked sci-bot.ru

Has “Minimum amino acid residues of an α-helical peptide leading to lipid nanodisc formation”10/21/14 been linked to all biophysically constrained biodiversity on Earth via “Hydrophilic interaction chromatography and tandem mass spectrometry for the characterization of methylated oligoribonucleotides” (indexed 5/7/26)

Sci-bot.ru claimed it could not find “Hydrophilic interaction chromatography and tandem mass spectrometry for the characterization of methylated oligoribonucleotides” (indexed 5/7/26), but reported support for my model as The multiscale feedback theory of biodiversity 9/28/22

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