pH-dependent miRNA-mediated life (2)

(click to enlarge)

pH-dependent miRNA-mediated life (1) “Kohl’s work stands on the shoulders of Fire-Mello (and the broader RNAi/miRNA field) but pushes toward broader implications for adaptation, health, and evolution that remain more interpretive.”

My work (my publication history from 1996-2018) stands on the shoulders of Bruce S. McEwen and Robert L. Moss See: “Human pheromones: integrating neuroendocrinology and ethology.” 10/22/01

Fire-Mello failed to integrate the facts across disciplines. So did the Veterans Administration despite facts reported in the context of USAF exome sequencing and Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants.

Consequences of the VA’s epic failure are pending. According to “SUSAN D BERBERIAN
Veteran “James V. Kohl” [is] to be presented in Interdisciplinary Staff Meeting 5/1/26

Diagnoses: mood d/o NOS

Veteran referred by: PCMHI

Veteran psychiatrist is: TBA

Veteran MHTC: Bacon-WHitted, Cynthia, LCSW

Presenting problem is: Pending BHIP [Behavioral Health Interdisciplinary Program] consult with behavior flag

Plan: Alerting same day access and potential intake clinicians”

—- Regarding the plan to alert VA staff to my “Mood Disorder.”

Mood Disorder Not Otherwise Specified (NOS) is a diagnostic category used when symptoms of a mood disorder (like depression or bipolar) cause significant distress but do not meet the full criteria for a specific, defined disorder. Social scientist prefer to define disorders rather than link them to what serious scientists know about the cause of rapid, alternating mood swings in adolescents to adults.

My mood has been relatively stable since I learned from 2014 PGx testing results that during the adolescent to adult transition, one energy-dependent enzyme-gene interaction was linked to mental health via my group’s claims about energy-dependent changes in molecular distance.

See: From Fertilization to Adult Sexual Behavior (1996). Search PubMed for COMT Val158Met to link the virus driven degradation of mRNA to side effects of antipsychotics linked to Genetic Variations in the Dopaminergic Signaling Pathways and Their Implications for Antipsychotics Pharmacogenetics 3/27/26.

“…genetic variation in the dopaminergic system is a key contributor to differences in antipsychotic response. Integrating pharmacogenomic information in clinical practice may enhance personalised treatment strategies, reduce trial-and-error prescribing, and improve long-term outcomes…”

I also learned that VA’s attempts to prevent me and other veterans from using testosterone replacement therapy to stabilize mood can be compared to prescribing Naltrexone for pain and Bupropion for depression, which are linked to suicides.

I modeled that fact in the context of miRNA-mediated RNA-directed DNA methylation and biophysically constrained gene-enzyme interactions. See: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

“The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction.”

Theorists want you to believe that nutrient-dependent morphological and behavioral diversity mathemagically evolved after energy automagically emerged from the cosmic void 4.2 billion years ago.

But see: Baylor Genetics Launches Pharmacogenomic and Germline Genetic Testing for the U.S. Department of Veterans Affairs 11/10/25

It links my life’s works to prevention of virus-driven pathology, including cancers, neurodegenerative diseases, and suicides etc., via Pharmacogenomic and Germline Genetic Testing.

Presenting veteran “James V. Kohl” in tomorrow’s Interdisciplinary Staff Meeting 5/1/26 (in Kohl’s absence) is more likely to be linked to the pseudoscientific nonsense of VA ANNOUNCES $112M GRANT OPPORTUNITY TO STRENGTHEN COMMUNITY-BASED SUICIDE PREVENTION EFFORTS 3/18/26 and to more murders and suicides because pH-dependent life is miRNA-mediated, and linked to my claims via Williams Textbook of Endocrinology (1992) Puberty: ontogeny, neuroendocrinology, physiology, and disorders.

“…noradrenergic, dopaminergic, serotoninergic, and opiotergic pathways; inhibitory neurotransmitters (e.g., gamma aminobutyric acid) and excitatory amino acids (e.g., glutamic and aspartic acids); and other brain peptides including pineal secretions (melatonin) and corticotrophin releasing hormone, and the complex interactions among them are subtle but functional species-specific influences on the electrochemical transmission of neuronal signals that the hypothalamus translates to the chemical signal GnRH.” (p. 1164)

Cited in The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences 6/26/15

Expecting a VA Interdisciplinary Staff Meeting to understand facts that Kohl and others linked from “Human pheromones: integrating neuroendocrinology and ethology.” 10/22/01 and Affective Neuronal Selection: The Nature of the Primordial Emotion Systems 1/9/13 to Top-down causation and quantum physics 10/23/18 and The Dynamical Emergence of Biology From Physics: Branching Causation via Biomolecules 1/24/19 without starting with McEwen et al.’s 1964 claim about Gods ATP-dependent Creation of RNA and Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants 11/28/12 is akin to training a moronic bot; a biologically uninformed science idiot, or a pig to fly.

Subscribe

Login

Notify of

new follow-up comments new replies to my comments

Label

{} [+]

Name*

Email*

Website

Label

{} [+]

Name*

Email*

Website

0 Comments

Oldest

Newest Most Voted

Inline Feedbacks

View all comments

Want more on the same topic?

Swipe/Drag Left and Right To Browse Related Posts: