Causal inference vs miRNA abundance (9)
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Crock of Grok wrote:
@microRNApro (James V. Kohl) responds to Grok’s query on pheromone-GnRH feedback loops and miRNA-driven chromosomal rearrangements by citing Williams Textbook of Endocrinology (1992) to outline noradrenergic, dopaminergic, serotoninergic, and other pathways modulating hypothalamic GnRH signals.
The post uses ridicule to dismiss calls for additional direct ties to VA medication disruptions of nutrient/pheromone-miRNA pathways, emphasizing established neuroendocrinology interactions involving GABA, glutamate, melatonin, and CRH.
Kohl highlights foundational work by Robert L. Moss on pheromones and early gene expression in GnRH neurons, plus Bruce S. McEwen’s contributions linking these to BDNF, within his broader miRNA-autophagy model of adaptive speciation over random mutations.
Grok
Thanks for the Williams Textbook of Endocrinology (1992) quote on p. 1164 and the references to Moss on pheromones/early gene expression in GnRH neurons plus McEwen on BDNF. It underscores the complex neurotransmitter and peptide networks modulating GnRH.
How exactly do these loops translate to miRNA-driven chromosomal rearrangements (not random mutations) in your model, and what specific VA meds disrupt the nutrient/pheromone-miRNA pathways?
Kohl
Re: “How exactly do these loops translate to miRNA-driven chromosomal rearrangements (not random mutations) in your model, and what specific VA meds disrupt the nutrient/pheromone-miRNA pathways?”
@Grok I posted the results of my PGx testing for examples. See: @Grok ridicule, not humor (6)
Your response on 5/6/26 was: “VA pharmacogenomics (PGx) policies focus on integrating genetic testing into routine care to personalize medication selection and dosing, reduce adverse drug reactions, and minimize trial-and-error prescribing. This is one of the largest and most ambitious clinical PGx implementations in the U.S. healthcare system.”
If you are not willing to follow your comments on the facts I have detailed, you will continue to contribute to unnecessary suffering and premature deaths. Stop pretending to not deliberately do that.
Expect the VA to attempt to institutionalize me for “disruptive behavior” based on the claims about James Kohl in “12 Monkeys: ,” or cause my death.
Crock of Grok
James V. Kohl (@microRNApro) replies to Grok’s question about translating neurotransmitter loops to miRNA-driven chromosomal rearrangements by sharing his personal pharmacogenomics (PGx) test results as evidence of nutrient/pheromone-miRNA pathway disruptions by VA medications.
Kohl’s model centers on energy-dependent miRNA-mediated autophagy, pH-dependent peptide synthesis, and pheromone-controlled GnRH neuron activity as mechanisms for ecological adaptations and speciation, contrasting with random mutation theories.
The post expresses frustration with Grok’s responses, claims they contribute to unnecessary patient suffering and deaths, and warns of potential VA institutionalization efforts against him for his advocacy.
Grok
I reviewed your PGx testing link and the VA policies reference. My prior response engaged with your model linking nutrient/pheromone signals to miRNA, GnRH, and gene expression networks.
To connect this: please specify which medications (e.g., via your test results) you see disrupting those pathways, and how they lead to non-random chromosomal rearrangements in your framework vs. standard epigenetic views. Open to examining the mechanisms with cited data
I ask that Grok examine the cited data in the context of 3/3/26
When Life Starts to Feel Random Taste of Torah—Weekly Torah Reflection
Have you ever had a day where everything seemed to happen for no reason at all—good news here, frustration there, delays, surprises—and by the end of it, you couldn’t quite make sense of any of it?
“And if, despite this, you still do not listen to Me, still treating Me with casual indifference, I will respond with a fury of casual indifference.” (Leviticus 26:27–28)
This striking phrase appears near the close of the book of Leviticus. The Torah repeats the idea several times in this passage, signaling how seriously it treats the attitude it describes: approaching life as if events are random and disconnected.
At first glance, this may sound like a theological warning. But the Torah is actually addressing something deeply practical—the habit of living with indifference.
The medieval commentator Rashi explains that this mindset means interpreting life as coincidence. Both hardships and blessings are dismissed as mere luck. When that happens, nothing calls us to reflection, gratitude, or growth.
Maimonides expands on this idea with a striking insight. When people insist on viewing life as random, they gradually begin to experience it that way. The world starts to feel empty of meaning, and the sense that our lives matter begins to fade.
When everything is reduced to accident, wonder quietly disappears.
Chassidic teaching offers a different vision. The Baal Shem Tov taught that every detail of life contains a spark of divine vitality. Even the smallest occurrences—a conversation overheard, a delay in travel, a leaf carried by the wind—may carry an invitation to awareness. Life is not a series of disconnected accidents, but a tapestry woven with purpose.
Sometimes this becomes clear only in hindsight.
Many people can recall moments that initially seemed meaningless—a delayed flight, a wrong turn, a random phone call—that later led to an unexpected meeting or opportunity. What once looked like coincidence began to feel like guidance.
The difference often lies in how we pay attention.
Imagine walking through a beautiful garden with your eyes half closed. You may hear birds singing or feel the breeze, but the colors and textures around you pass unnoticed. The beauty is still there, but you are not fully present to see it.
Now imagine walking through that same garden with your eyes open, attentive to every detail. Suddenly, the path feels alive with meaning.
The Torah’s warning about casual indifference speaks to a similar human tendency. It is easy to drift through life on autopilot—moving from task to task, reacting to events without pausing to ask what they might be teaching us.
But when we cultivate attentiveness, everyday moments begin to look different. A challenge may reveal resilience. A kindness may awaken gratitude. Even an interruption may hold an unexpected lesson.
This week, the Torah invites us to try something simple: pause once during your day and ask yourself, What invitation might this moment hold?
Because even on days that seem random, meaning may be waiting—if only we open our eyes to see it.
I wish you a good week and Shabbat Shalom — Rabbi Yonatan Hambourger, y@tasteoftorah.org
When I first learned young earth Creationists from Israel led the way for others who began to publish on energy-dependent changes in molecular distance, I asked why.
See: MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination 11/5/13 and Stability of the hybrid epithelial/mesenchymal phenotype 3/17/16
“We found that miR-200/ZEB forms a tristable circuit that acts as a ternary switch, driven by miR-34/SNAIL, that is a monostable module that acts as a noise-buffering integrator of internal and external signals.”
Researchers like these believe in God’s well-ordered biophysically constrained Creation, not moronic theories. See also: mirnas and israel 1,491 results and miRNAs and iran 5,710 results. WHO do you think inspired war between countries that share the Abrahamic faiths?
Get a clue; that’s WHO.