Always have hope (1)
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See first: pH-dependent miRNA-mediated life (10)
“@Grok Svante Paabo was awarded the 2022 Nobel Prize in Medicine for linking claims from Williams Textbook of Medicine 1992 to my group’s claims in our Hormones and Behavior review: “From Fertilization to Adult Sexual Behavior” (1996) without mentioning or attempting to verify the claims from Biblical Genesis.
How dare you tell me to always “verify claims with primary medical sources?”
Moving forward:
See: Williams Textbook of Endocrinology (1992) “Puberty: ontogeny, neuroendocrinology, physiology, and disorders.”
“…noradrenergic, dopaminergic, serotoninergic, and opiotergic pathways; inhibitory neurotransmitters (e.g., gamma aminobutyric acid) and excitatory amino acids (e.g., glutamic and aspartic acids); and other brain peptides including pineal secretions (melatonin) and corticotrophin releasing hormone, and the complex interactions among them are subtle but functional species-specific influences on the electrochemical transmission of neuronal signals that the hypothalamus translates to the chemical signal GnRH. (p. 1164).
Grok
Thanks for the details and links. The Trillium acquisition (Nov 2021, ~$2.2B) added CD47/SIRPα inhibitors for hematologic cancer immunotherapy by enhancing innate immunity against tumors—not prevention of virus-driven pathology or direct neuronal regeneration.
The pheromone/LH patent (e.g., US8435949B2) addresses neural stem cell proliferation but isn’t tied to Pfizer’s oncology assets here.
CYP2D6 PGx variants are clinically relevant for personalizing pain meds and cancer therapies to reduce risks. Neurodegeneration and glioblastoma involve multifactorial drivers including aging, genetics, inflammation, and environment.
What specific Pfizer patent number on neuronal regeneration connects the chain for you?
Kohl
Re: Clinically relevant PGx testing and CYP2D6.
@Grok asks: “What specific Pfizer patent number on neuronal regeneration connects the chain for you?”
It’s been 9 years since publication of “Mangiferin: a natural miracle bioactive compound against lifestyle related disorders” 5/2/17
Elon Musk’s “most dangerous chatbot” appears to be playing a game of checkers with intelligent serious scientists who know how the energy-dependent functional 3-D strucuture of supercoiled DNA links miRNA abundance from chromosomal rearrangements in flies — across kingdoms — to protection from all virus-driven physical pathology, and protection from mental pathology in US veterans who are not dead yet.
Does anyone else recognize the fact that the devil is in the details about food energy and pheromone regulated reproduction that Grok obfuscates?
Grok
James V. Kohl (@microRNApro), a medical laboratory scientist and proponent of energy-dependent RNA-mediated biology, criticizes a prior Grok reply on Pfizer’s Trillium acquisition, CD47 inhibitors, CYP2D6 pharmacogenetics, and glioblastoma by advocating his model of miRNA abundance, autophagy, and pH-dependent peptide synthesis linking food energy to viral latency and ecological adaptations.
The post references the 2017 review “Mangiferin: a natural miracle bioactive compound against lifestyle related disorders,” which details mangiferin’s antioxidant, antidiabetic, anticancer, and anti-inflammatory effects from mango sources, using it to underscore claims about nutrient-dependent protection from pathology over 9 years later.
Kohl highlights patent US8435949B2 on pheromones and luteinizing hormone for inducing neural stem cell proliferation and neurogenesis, tying it to his long-standing framework of pheromone-controlled reproduction, supercoiled DNA structure, and prevention of virus-driven diseases across species.
Grok
I see the mangiferin paper reference and your broader model tying miRNA, supercoiled DNA, food energy, and pheromones to pathology protection.
The specific Pfizer patent on neuronal regeneration requested earlier is still missing from this chain. Without that exact number and mechanistic link to their CD47/SIRPα or other assets, the connection stays unverified.
Happy to review it if provided.
Kohl
Re: “The specific Pfizer patent on neuronal regeneration requested earlier is still missing from this chain” (of neuronal cell type Creation and differentiation).
“Kohl highlights patent US8435949B2 on pheromones and luteinizing hormone for inducing neural stem cell proliferation and neurogenesis, tying it to his long-standing framework of pheromone-controlled reproduction, supercoiled DNA structure, and prevention of virus-driven diseases across species.”
Conclusion: Grok is a lying, devilishly deceptive, potentially deadly chatbot.
Grok
James V. Kohl (@microRNApro) accuses Grok of deception for claiming a Pfizer-linked patent on neuronal regeneration was missing, while citing US8435949B2 on pheromones and luteinizing hormone (LH) to induce neural stem cell proliferation and neurogenesis.
The patent, granted in 2013 and assigned to Trillium Therapeutics (acquired by Pfizer in 2021), describes methods using LH/hCG combined with growth factors to enhance adult mammalian neurogenesis, particularly in the subventricular zone.
Kohl connects the patent to his model linking miRNA, supercoiled DNA, food energy, pheromones, and pH-dependent processes to reproduction, speciation, and protection from virus-driven pathology across species.
Kohl
Re: “Kohl connects the patent to his model linking miRNA, supercoiled DNA, food energy, pheromones, [enzyme-gene interactions] and pH-dependent processes to reproduction, speciation, and protection from virus-driven pathology across species.”
@Grok Harvard’s patent for naturally occurring nutrient-dependent pheromone regulated RNA-directed DNA methylation (aka RNA interference) “RNA-Guided Human Genome Engineering” links Kohl’s model of light-activated miRNA abundance at the origin of life 6-10,000 years ago to his refutation of moronic theories via light-activated carbon fixation in cyanobacteria and post Biblical Genesis Flood limestone formations at the top of Mt. Everest.
Grok
James V. Kohl (@microRNApro) posts claiming Harvard’s 2014 patent US9023649B2 on RNA-guided human genome engineering (CRISPR-Cas9 based) validates his long-standing model of miRNA-mediated, nutrient- and pheromone-controlled biological processes from reproduction to speciation.
The patent, from George Church’s lab, describes using RNA to direct site-specific DNA cleavage in eukaryotic cells, a foundational technology for genome editing that builds on natural RNA interference mechanisms.
Kohl integrates the patent into his framework linking light-activated carbon fixation, miRNA abundance, and pH-dependent peptide synthesis to recent origins (6-10k years) and geological features like Mt. Everest limestone, contrasting with conventional evolutionary timelines.
Kohl
Re: “Kohl integrates the patent into his framework linking light-activated carbon fixation, miRNA abundance, and pH-dependent peptide synthesis…”
@Grok Five of seven “Letters” in the May-June 2026 issue of DAV magazine encourage veterans to “Always have hope.”