miRNA abundant life (4)

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miRNA abundant life (3)

This evidence supports the claim that Grok AI will continue to be Elon Musk’s most dangerous killer chatbot. See:

Phasevarions mediate epigenetic regulation of antimicrobial susceptibility in Neisseria meningitidis 6/12/14

“The MIC results (Table 1) revealed that the ModA11- and ModA12-containing strains were more sensitive to several antibiotics when the Mod protein was expressed and DNA was methylated”

Phasevarions-mediated epigenetics links an energy-dependent regulatory system in bacteria to biophysically constrained random, reversible switching of a single DNA methyltransferase in which RNA-directed DNA methylation links protection from the virus-driven degradation of mRNA to controlled expression of multiple genes.

Grok

The X post links to the author’s blog on “miRNA abundant life,” highlighting miRNA’s role in regulating gene expression, chromosomal stability, and adaptations from bacteria to complex organisms like elephants.
It references a 2014 study on phasevarions in Neisseria meningitidis, where reversible switching of DNA methyltransferases alters global methylation patterns and antibiotic susceptibility in an energy-dependent manner.
The author connects these bacterial epigenetic mechanisms to RNA-directed processes and virus protection, framing them as evidence that Grok AI overlooks key miRNA-biophysical links in favor of theoretical models.

Rockefeller University 9/4/26

“On any given day, depending on the weather, I might work on optimizing an organizational procedure, or I might mow a field. I never know, and that’s the beauty of my job.

Rockefeller’s Bruce McEwen taught me to link the ATP-dependent Creation of RNA to refutation of moronic theories. On any given day I continue to do that by citing the extant research on miRNA. For examples, see: 200,859 results

Learn more about epigenetic effects on glucose metabolism and phasevarions-mediated life. (37,772 results)

See also: The Lin28/let-7 Axis Regulates Glucose Metabolism 9/30/11

“Our report implicates Lin28a/b and let-7 as important modulators of glucose metabolism through interactions with the insulin-PI3K-mTOR pathway and T2D-associated genes identified in GWAS. Although it is likely that additional mechanisms and feedback loops exist, our data suggests a model whereby Lin28a/b and let-7 coordinate the GWAS identified genes and the insulin-PI3K-mTOR pathway to regulate glucose metabolism (Figure 6E). It also suggests that enhancing Lin28 function or abrogating let-7 may be therapeutically promising for diseases like obesity and diabetes. Likewise, results from this work might shed light on the physiology of aging and, specifically, how the accumulation of let-7 in aging tissues may contribute to the systemic insulin resistance that accompanies aging.“

See also: Phasevarions and miRNAs 78 results

Mediating Cross-Talk: How Uterus-Derived Extracellular Vesicles Influence Early Embryo Development and Implantation

“This review summarises the multiple effects of uterus-derived EVs on successful embryo implantation, including the effects on pre-implantation embryo development and embryo implantation ability.”

For comparison, see my group’s 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior. We linked energy-dependent changes in molecular distance from chromosomal rearrangements and sex differences in yeasts across kingdoms via RNA-directed DNA methylation.

“Molecular epigenetics. It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes.”

RNA-directed DNA Methylation 10/8/20

Overall, RdDM is an important pathway in plants that regulates a number of processes by establishing and reinforcing specific DNA methylation patterns, which can lead to transgenerational epigenetic effects on gene expression and phenotype.

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