miRNA abundance tunes cosmological constants (4)

By: Jim Kohl | Published on: July 17, 2026

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miRNA abundance tunes cosmological constants (3)

See for facts: “The EV-mitochondrial outsourcing network as a therapeutic target for age-related testosterone deficiency: from network collapse to clinical intervention” 6/22/26
“…network dysregulation transmits damage from the interstitium to the seminiferous tubules through three pathways—testosterone deficiency, aberrant paracrine factors, and the “toxic transformation” of EV signals—ultimately leading to impaired spermatogenesis and reduced male fertility. The disruption of this paracrine network further explains why exogenous testosterone supplementation alone cannot fully restore fertility…” in mules with chromosomal rearrangements the completely compromise fertility via the same pathways linked to testosterone replacement therapy and trangenerational epigenetic inheritance of morphological and behavioral phenotypes in species that are not extinct in the wild, or cancer-free African elephants.

Moving forward, see: A Programmable mRNA Platform for miRNA Detection via miRNA–mRNA2 Triplex-Mediated Ribosomal Frameshifting 7/16/26

Kohl
“Whole-transcriptome-scale isoform-resolved spatial imaging of single cells in tissues” 7/16/26
Programmed isoform usage is energy-dependent and miRNA-mediated. It was predicted by Darwin’s “conditions of life” (1859) and Merian’s (1679) link from the diet of caterpillars to their metamorphosis into moths. See” Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability” 1/5/21 and “The extent of codon usage bias in human RNA viruses and its evolutionary origin‘ 2/28/03 Be the polymath, not the moronic theorist.

Grok
The post by @microRNApro highlights a July 16, 2026 Cell paper on isoform-resolved spatial transcriptomics in mouse brain tissues, claiming its findings on programmed isoform usage align with energy-dependent, miRNA-mediated mechanisms predicted by Darwin’s conditions of life and Maria Sibylla Merian’s 1679 caterpillar observations.
The paper introduces RT&T-AMP-MERFISH to image ~23,000 genes and ~10,000 isoforms at single-cell resolution, demonstrating region- and cell-type-specific isoform patterns like Mef2c enrichment in brain areas, without mentioning miRNAs or energy dependence.
Author James V. Kohl promotes a biophysical model linking miRNA biogenesis, pH-dependent processes, and codon usage to constraints on gene expression, viral latency, and sympatric speciation across species.

Kohl
Re: “energy-dependent, miRNA-mediated mechanisms predicted by Darwin’s conditions of life and Maria Sibylla Merian’s 1679 caterpillar observations” demonstrated “region-and cell-type-specific isoform patterns…in brain areas, without mentioning miRNAs or energy dependence.
@Grok Intelligent serious scientists do not repeat facts that link cosmological constants to miRNA-mediated fine-tuning of biophysically constrained healthy longevity. Facts about energy-dependent miRNA abundance and fine-tuning of cosmological constants make moronic theories examples of human idiocy in 199,296 results from today’s search of PubMed for indexed articles that mention the term “miRNA.” See, for instance: “A Programmable mRNA Platform for miRNA Detection via miRNA-mRNA2 Triplex-Mediated Ribosomal Frameshifting 7/16/26
Reminder: “miRNA-mRNA2 Triplex-Mediated Ribosomal Frameshifting” is the obvious link to energy-dependent cosmological constants.

Kohl
This band-standing links shadow banning/censorship of my posts @microRNApro to his “Glory to Mars, our eternal home video.” President Trump gives the Glory to God.

Karoline Leavitt wrote
Most billionaires stay neutral to protect profits.

@elonmusk risked everything—bankruptcy, jail, even assassination—to fight the deep state and restore free speech by buying Twitter.

Can we pray for his safety together?

NO! This is more propaganda than ever. 6/29/26

See for comparison: “Whole-transcriptome-scale isoform-resolved spatial imaging of single cells in tissues” 7/16/26