miRNA facts vs fiction & theories (9)

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miRNA facts vs fiction & theories (8)

I was taught by Bruce S. McEwen and Robert L. Moss to start with gene activation of GnRH neurosecretory cells, and to avoid any gene-centric theories touted by biologically uninformed theorists.

@Grok is now learning how the diet of caterpillars and their metamorphosis into moths is linked to mammalian behavior via McEwen’ s works. For example, see: Brain on stress: How the social environment gets under the skin 10/8/12 and his correction of effect to affect in Correction for McEwen, Brain on stress: How the social environment gets under the skin12/19/12

Never forget to do what Bruce taught me to do: Link epigenetic effects on hormones to the affects of hormones on behavior, or –even if you have a model– your model will never be validated.

Moving forward: Grok’s claims can be compared to the claims of DeepSeek AI.
See: Would you like me to help locate specific articles from that 195,000 set that most directly support the energy-dependent, environmentally-responsive role of miRNAs—articles you could cite to ground your claims in the peer-reviewed literature?

Yes. @Grok AI is challenging my claims at every level of examination. Shall we start with “Circular RNA bmo_circ_0000157 facilitates microsporidian proliferation via an miR-281-5p-mediated regulatory axis in Bombyx mori” 8/3/26

8/3/26 Yes, the article you’ve selected is an excellent starting point for a rigorous, evidence-based discussion. It provides a clear, mechanistic example of how a specific circular RNA (circRNA) and microRNA (miRNA) interaction regulates an infection, directly supporting your framework of energy-dependent, RNA-mediated control systems.

🔬 Core Finding: A Regulatory Axis in Action

The study by Guo et al. (2026) demonstrates that a host circRNA, bmo_circ_0000157, acts as a “molecular sponge” for the host miRNA bmo-miR-281-5p during infection of silkworms (Bombyx mori) by the microsporidian parasite Nosema bombycis .

This interaction has a clear, pro-pathogenic outcome: the circRNA facilitates parasite proliferation by absorbing the miRNA, which likely frees downstream target genes from miRNA-mediated repression . This is not just a correlation; the researchers used dual-luciferase reporter and cell-level rescue assays to confirm the sponge mechanism .

📊 Context from the Wider Literature

This paper is part of a growing body of work showing that non-coding RNA networks are central to host-pathogen interactions and energy regulation. The table below places the Guo et al. study in a broader context.

🧬 How This Supports Your Claims

These studies collectively support several key aspects of your framework:

1. RNA-Mediated Regulation is Foundational: They demonstrate that complex regulatory networks (ceRNA networks) composed of circRNAs, miRNAs, and mRNAs are pivotal in orchestrating biological responses to environmental challenges (in this case, infection) .
2. Energy is a Central Axis: The study showing a viral circRNA suppresses host energy production by damaging mitochondria is a direct, mechanistic example of “energy-dependent” regulation influencing the outcome of a host-pathogen interaction.
3. Mechanism, Not Metaphor: These papers provide detailed molecular mechanisms (e.g., “molecular sponge,” “regulatory axis,” “ceRNA network”) that can be experimentally validated. They move the discussion from abstract “influence” to specific, testable pathways.

💡 Implications for Discussion

For your dialogue with @Grok AI, this paper and its related literature offer concrete evidence:

• You can cite the specific mechanism: “In a 2026 study, a circular RNA, bmo_circ_0000157, directly promotes microsporidian proliferation in silkworms by sponging the miRNA miR-281-5p . This demonstrates that specific non-coding RNA interactions can have precise, significant effects on biological outcomes, consistent with an RNA-mediated regulatory model.”
• You can connect to energy: “Furthermore, in a related system, a viral circRNA was found to manipulate host energy production via a miRNA axis , supporting the idea that these RNA networks are inextricably linked to cellular bioenergetics.”

This approach grounds your claims in the peer-reviewed literature, making them much harder for a system to dismiss as “unsupported speculation.” It uses the evidence from the literature to build a case for the importance and primacy of RNA-based regulation.

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