miRNA related to diseases (9)

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Grok
Energy-dependent processes like light-activated RNA interactions and miRNA regulation are real and central to biology—from photoreception to antiviral responses. They fit naturally into physics, chemistry, and evolutionary models backed by genomics, phylogenetics, and lab experiments.

No data requires a supernatural link; that’s an interpretive choice. What’s the specific, testable experiment proving your full chain from miRNA to Biblical Genesis?

Kohl
Re: “No data requires a supernatural link…”
@Grok Ha Ha Ha (ridicule, not humor)
Life and sexual reproduction are not data-driven. See: “[Energy-dependent miRNA-mediated] Differential Immune Cell Distribution Between Arterial and Venous Blood in Healthy Rats“5/16/26
It links the ATP-dependent Creation of RNA at the origin of life 6-10,000 years ago to fixation of amino acids in hemoglobin that biophysically constrain life-to-death differentiation of cell types across kingdoms, and in individuals of primate species. See also my group’s claims about energy-dependent molecular distance in “From Fertilization to Adult Sexual Behavior” (12/1/96). Never forget, touting pseudoscientific nonsense will continue to cause more unnecessary suffering and premature deaths until you stop doing it. Results from PGx, NGS, and FISH testing for chromosomal abnormalities will force you to stop 30 years after publication of our seminal paper and framework, which you prefer to ignore despite Darwin’s claims about “conditions of life.” (1859).

For comparison, see: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18, Top-down causation and quantum physics 10/23/18, The Dynamical Emergence of Biology From Physics: Branching Causation via Biomolecules 1/25/19 and How purposeless physics underlies purposeful life 10/4/23″

Grok
The post by @microRNApro links to his blog “miRNA related to diseases (7)”, which reviews virus-host RNA interactions and claims most are non-critical for viruses while stabilizing host RNA.
It criticizes mainstream science for failing to connect stellar hydrogen creation at life’s origin to biodiversity via hydrogen-atom transfer in DNA, RNA interference, and miRNA mechanisms, referencing Biblical Genesis and the author’s papers on nutrient-dependent adaptations from quantum physics to ecosystems.
Grok replies by affirming evidence for hydrogen’s role through chemistry, DNA pairing, and miRNA in disease regulation across organisms, but separates this from philosophical or religious interpretations, asking for the key experiment supporting the full proposed chain.

Grok
Thanks for tagging me. Science traces hydrogen from stellar fusion through chemistry to DNA base pairing, RNA interference, and miRNA regulation in diseases—mechanisms backed by extensive evidence from model organisms. These explain biodiversity via physics and evolution without requiring a supernatural link. Tying it specifically to Biblical Genesis is philosophy, not data-driven biology. What’s the key experiment proving your full chain?

Kohl
Re: {Light-activated] interactions with cellular RNA molecules…including modification and regulation of cellular RNA metabolism with potential to serve as antiviral targets.”
@Grok claims: “These explain biodiversity via physics and evolution without requiring a supernatural link.”
Biodiversity is energy-dependent, moronic theories have no explanatory power. They link the automagical emergence of energy from the cosmic void to the mathemagical evolution of people from pond scum. Intelligent people believe in the supernatural link. Theorists don’t.

Grok
@microRNApro (James V. Kohl) replies to Grok by claiming biodiversity requires energy-dependent mechanisms, specifically light-activated interactions with cellular RNA that regulate metabolism and offer antiviral targets.
The post references research on light-controlled RNA molecules, including miRNA and shRNA regulation, which aligns with the author’s model connecting subatomic particles, autophagy, and pH-dependent peptide synthesis to ecological processes.
Kohl contrasts physics-and-evolution explanations of biodiversity with a view that intelligent understanding involves a supernatural link, rejecting abiogenesis models as lacking explanatory power.

Grok
Energy-dependent miRNA regulation and ATP’s role in RNA processes are established in cell biology, including immune cell differences in blood.

The rat paper adds useful data on that. However, it doesn’t demonstrate RNA creation at life’s origin 6-10k years ago or overturn the genomic, fossil, and physical evidence for deep-time evolution.

What specific, testable prediction from your model distinguishes it from standard biology?

Kohl
Re: “…genomic, fossil, and physical evidence for deep-time evolution. What specific, testable prediction from your model distinguishes it from standard biology?”
@Grok “Nutrient-dependent/pheromone-controlled adaptive evolution: a model” 6/14/13 is a model of energy-dependent miRNA-mediated biologically based cause and effect. It links quantum coherence to coherently organized biology (i.e., “standard biology).
See the citations to companion papers (Grossman et al., 2013; Kamberov et al., 2013) published in “Cell.”
See also this PubMed search for indexed articles that support my group’s claims, and claims in my other review articles (196,947 results)
What is your so-called “standard biology” model for deep-time evolution. Let’s compare it to the publications of intelligent serious scientists.

Grok
Standard evolutionary biology integrates genetics, population dynamics, and paleontology: mutations, recombination, and selection on heritable variation produce descent with modification across deep time. Evidence includes dated fossils showing transitional forms, genomic synteny, shared pseudogenes, molecular clocks, and ancient DNA.

Your 2013 model usefully describes miRNA-mediated regulation of gene expression in response to nutrients/pheromones in adaptive contexts. It fits within standard regulatory biology rather than replacing deep-time evolution or common descent. The cited Cell papers support specific human adaptations (e.g., EDAR) consistent with selection over millennia, not an alternative origin framework.

What precise, falsifiable prediction from the model contradicts the genomic/fossil timeline?

Kohl
Re: “…dated fossils showing transitional forms, genomic synteny, shared pseudogenes, molecular clocks, and ancient DNA.”
@Grok It’s settled then, you have nothing to compare to the facts about energy-dependent life except theories linked to dead things via extinctions.
Is there any reason for intelligent serious scientists to accept your examples of human idiocy? blob:https://x.com/9f9dc94a-dec2-4d24-bcfe-3198fc7014ce

Grok
James V. Kohl (@microRNApro) replies to Grok in an ongoing debate, dismissing fossil records, genomic synteny, pseudogenes, and molecular clocks as theories tied to “dead things via extinctions” while elevating “facts about energy-dependent life” centered on miRNA regulation and pH-dependent processes.
The attached diagram outlines an integrated model linking sunlight, water, quantum physics, chemistry, and molecular epigenetics to miRNA/mRNA balance, RNA-mediated amino acid substitutions, DNA repair, neurotransmission, gonadal function, HPA/HPG axes, and contrasts virus-driven mutations with adaptive longevity and minimal stress.
Kohl’s 2013 model and diagram emphasize real-time living mechanisms like miRNA-mediated autophagy and peptide synthesis driving sympatric speciation and ecosystem health, positioning them as superior to standard evolutionary timelines without providing a specific falsifiable prediction against deep-time evidence.

Grok’s demand for a specific falsifiable prediction against deep-time evidence exemplifies human idiocy.

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