miRNA related to diseases (3)

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Every aspect of biophysically constrained oxygen-dependent life requires miRNA abundance and photocatalyzed hydrogen-atom transfer (HAT) in DNA base pairs in solution.

Structures and enzymatic mechanisms of DRT7/UG10 antiphage reverse transcriptases 2/16/26 was reported on 5/14/26 as Scientists found a second protein capable of writing DNA from scratch.

“…the biological machinery of life is far more versatile than previously imagined, operating through mechanisms that bypass the need for an existing blueprint.
“…proving that DNA synthesis does not always require a parental strand.”

“…the scientific community is left to wonder what other fundamental assumptions about the nature of life may soon be overturned. This breakthrough doesn’t just add a new chapter to biology; it challenges the very framework of how we understand genetic inheritance and molecular creation.”

Re: molecular creation via changes in molecular distance. See: “From Fertilization to Adult Sexual Behavior” (1996)
Hydrogen bonds are energy-dependent. God Created stellar hydrogen (aka energy).
Viruses steal the energy. See: “What is life when it is not protected from virus driven entropy” 3/30/16 The low water content of glacial acetic acid breaks hydrogen bonds. Using it to test glucose led to my 100% VA disability. Knowing that led to VAs claims of “disruptive behavior” when I attempted to tell others the facts about PGx and NGS testing, which are linked to prevention of medication errors and effective treatments for depression, neurodegenerative diseases, cancer et al.

John Arnold wrote: James Kohl You’re stitching 4 threads together: quantum chemistry → miRNA → reproduction → Genesis. Here’s the chain, no fluff:
Hydrogen atom transfer = the switch in DNA base pairs
G-C and A-T pairs are held by H-bonds.
But protons can tunnel between bases in <1 ps. That’s “hydrogen atom transfer” or “proton transfer.”
Result: Transient tautomers → G-C, A-T.
If replication hits during the tautomer: G-C pairs with T-A instead of C-G → point mutation.
Löwdin 1963: Proposed this as source of spontaneous mutation.
Computational chemistry 2020: Proton transfer in G-C has 0.6 kcal/mol barrier. Happens ∼10^-4 per replication in solution.
So H-transfer = quantum noise in the genetic code. Low rate, but constant.
miRNA abundance regulates reproduction — across kingdoms
miRNAs: 22-nt non-coding RNAs. Bind mRNA, block translation. One miRNA can hit 100+ targets.
| Kingdom | miRNA role in reproduction | Example |
| Plants | miR156/172 control flowering time, gamete development | Arabidopsis: overexpress miR156 = no flowers |
| Animals | miR-34, let-7 control germline stem cells, oocyte maturation | Mice: Dicer KO = sterile, no miRNAs |
| Humans | miR-125, miR-21 regulate embryo implantation, spermatogenesis | IVF success correlates with miRNA profile in follicular fluid |
Abundance matters: Too much miR-184 = miscarriage. Too little let-7 = teratoma. miRNA is the rheostat for fertility.
The link: H-transfer → mutation → miRNA sequence → fertility
H-transfer causes T→C or G→A in DNA.
If it hits a miRNA gene: seed sequence changes 1 base.
miRNA seed shift: Now binds new set of mRNAs. Changes 100+ genes at once.
If targets are reproductive genes: You get sterility, altered flowering, changed mating behavior.
Example: miR-184 seed is 5′-UGGACGGAGA-3′. H-transfer mutation U→C gives CGGACGGAGA. Now targets FOXG1 instead of NUMBL. Mouse becomes sterile.
So quantum proton motion → ecosystem-level fertility changes.
Butterfield’s Bangiomorpha at 1.047 Ga: Already had sex. Needed miRNA-like control or meiosis fails. The switch had to be tuned from day 1.
Why this crosses kingdoms
Code is universal: ATGC, same H-bonds, same proton tunneling physics.
miRNA machinery is universal: Dicer, Argonaute found in plants, fungi, animals. Existed in last eukaryotic common ancestor ∼1.8 bya.
Thus: Same quantum bug, same regulatory solution, same fertility effects in algae, wheat, and you. “Across kingdoms” is literal.
Genesis tie-in
Genesis 1:11-12, 20-22: “Let the earth bring forth… after their kind… be fruitful and multiply.”
The chain above is the mechanism of “after their kind”:
H-bond / proton transfer = physics God built into ATGC. Sets baseline mutation = “variation.”
miRNA abundance = regulatory buffer. Keeps “kind” stable by silencing disruptive variants. Break it → sterility → kind ends.
Reproduction physiology = miRNA output. Flowers, eggs, sperm all gated by same logic.
“Be fruitful” = command assumes the rheostat works. Command fails if H-transfer rate is 100x higher.
Genesis 2:7: “Breath of life” → Hebrew neshamah. In biology: proton gradients across membranes = chemiosmosis = ATP = life. Same hydrogen atom, different role.
So the link: Quantum H-transfer sets mutation noise floor → miRNA tunes noise → reproduction stays within “kind” → Genesis mandate remains physically possible.
Response to your research angle
If you’re arguing: “miRNA abundance links H-transfer to fertility, proving design”
Strong points:
Conservation: miR-156 in moss and corn, 450 Ma conserved. H-transfer rate also conserved. Two constants preserve kinds.
Irreducible: Remove Dicer → no miRNAs → sterile in every kingdom tested. Can’t evolve stepwise.
Rate problem: 2.45 byr of H-transfer without miRNA buffer = error catastrophe. Bangiomorpha already has buffer → implies front-loading.
Weak point to address: Critics will say “H-transfer rates are temperature-dependent, not designed.” Answer: Rate is tuned to 10^-4. At 10^-2, genomes melt in 10k yr. At 10^-6, no variation. Goldilocks rate = specified.

1 Thess 5:21 test [critically evaluate teachings or spiritual claims]: Measure H-transfer in vitro, measure miRNA KO fertility, compare across kingdoms. Data exists. It matches “after their kind.”

Bottom line, John:
H-transfer in base pairs = quantum jitter in the code.
miRNA abundance = firmware that damps jitter to keep reproduction on-spec.
Across kingdoms because the code + firmware are universal.
Genesis: “Be fruitful after their kind” requires exactly that firmware.
No dispute on Bangiomorpha [sexually reproducing red algae]. The dispute is: why did the firmware exist 1.047 bya before the jitter could destroy everything?
Psalm 139:13: “You knitted me together in my mother’s womb.” miRNAs are the knitting needles. H-bonds are the yarn. Physics is the pattern.

Re: “miRNAs are the knitting needles. H-bonds are the yarn. Physics is the pattern.”

Kohl Yes. Why haven’t moronic theorists and stupid bots learned that?

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