miRNA abundance vs circular arguments (6)

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miRNA abundance vs circular arguments (5) “Re: Evidence based understanding: See “Direct and indirect regulation of fetal globin transcript by RNA-binding protein IGF2BP1” 6/24/26

Nothing about energy-dependent biophysically constrained protein folding chemistry across kingdoms has changed since my group reported on McEwen et al. (1964) and Dobzhansky (1964). Their claims linked the ATP-dependent Creation of RNA to species difference in hemoglobin molecules across kingdoms via fixation of hemoglobin variants that differentiate primate species.

Grok claims this ” fits alongside established miRNA roles in T-cell function, metabolism, and tumor suppression, plus exposome-driven epigenetic signals like DNA methylation…. through energy-dependent and environmental inputs…rather than invalidate prior evidence-based understanding.”

Moving forward (away from Grok AI’s displays of human idiocy, see: The Exposome and DNA Methylation: Epigenetic Signals from Environmental Stress

“DNA methylation is attractive because it can act as both a biological readout and a hypothesis-generating signal. At the molecular level, DNA methylation most often refers to 5-methylcytosine, or 5-mC, formed by DNA methyltransferases at cytosine bases. In mammals, 5-mC occurs mainly at CpG sites and is involved in gene regulation, genomic imprinting, transposon control, development, and cell identity [4]. A related mark, 5-hydroxymethylcytosine, or 5-hmC, is generated through TET-mediated oxidation of 5-mC and is especially relevant in development, neuronal biology, stem cell biology, and active DNA demethylation pathways.

This distinction matters in environmental epigenetics. A decrease in global 5-mC, an increase in methylation at a promoter, and a change in 5-hmC are not equivalent findings. They may point to different biology and require different assays.

What environmental stress can do to DNA methylation”

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