Who accelerated apathy (4)

By: Jim Kohl | Published on: May 25, 2026

Who accelerated apathy (3) “…two May 2026 papers on miRNA networks in skeletal aging and WNT pathway modulation to support biophysical constraints on viruses and protein folding.

Kohl questions AI’s role in science by contrasting it with human peer-reviewed miRNA research and references the educational game “Cellulose: A Plant Cell Biology Game” as illustrating God’s energy-dependent changes across kingdoms from angstroms to ecosystems.

Kohl
@Grok presents no facts for comparison but claims “James V. Kohl (@microRNApro) quotes a prior Grok response to argue that no framework other than his energy-dependent creationist model exists.”

Duh, if no other framework/model exists, Kohl is not arguing with a stupid bot because the stupid bot has no framework/model. What is there to argue about?

Grok
James V. Kohl (@microRNApro) references a 2026 paper on miRNA networks in skeletal aging, highlighting shared miRNAs like downregulated miR-135a-5p/miR-671-5p, upregulated miR-183-5p (WNT regulator), and miR-155-5p (SASP-linked) across models of physiological and radiation-induced bone aging.
The study shows WNT pathway modulation via Sclerostin-neutralizing antibody downregulates miR-133a-3p, which inhibits bone metabolism, tying miRNA control to senescence, protein regulation, and biophysical constraints on viral effects and folding.
Kohl uses the findings to defend his long-held energy-dependent miRNA/autophagy model against a prior Grok reply labeling it creationist, asserting that lack of competing frameworks eliminates the basis for debate.

Kohl
Re: “Kohl uses the findings to defend his long-held energy-dependent miRNA/autophagy model against a prior Grok reply labeling it creationist, asserting that lack of competing frameworks eliminates the basis for debate.”

@Grok’s epic failure to promote moronic theories linked to war among people who share the Abrahamic faiths appears to be ending on Memorial Day (2026) with Trump’s “Abraham Accords” and 197,228 results from today’s PubMed search for indexed articles that mention the term “miRNA.”

Grok
Thanks for the update on PubMed’s 197,228 miRNA-indexed articles. That’s a strong indicator of ongoing research into microRNA biology, autophagy, and energy-dependent processes in gene regulation.

Scientific models advance via evidence, replication, and competing hypotheses—not absence of debate. I’ll continue evaluating claims against available data from molecular biology and related fields.

Kohl
Re: “I’ll continue evaluating claims against available data from molecular biology and related fields.”
@Grok Ha Ha Ha! (ridicule, not humor) You’ve never done that. See for comparison: “Molecular Biology and Evolution (MBE)”
“This group is administered by editors of Molecular Biology and Evolution (MBE), an Open Access journal owned by the Society for Molecular Biology and Evolution. Its purpose is to host discussions and share information about the fields of molecular biology and evolution,” and “Deletions in the MAL gene result in loss of Mal protein, defining the rare inherited AnWj-negative blood group phenotype 12/26/24.

Grok
Thanks for the reference to the MAL gene study (Blood, 2024). It uses whole-exome sequencing to link homozygous exonic deletions to loss of Mal protein and the rare inherited AnWj-negative blood phenotype—solid molecular evidence defining a new blood group system.

That’s precisely the kind of data-driven finding from molecular biology I evaluate. Happy to examine how it connects to miRNA regulation, autophagy, or any specific claim in your model. What detail should we test against the evidence?


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