miRNA creation in the “garden of everything known” (7)

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miRNA creation in the “garden of everything known” (6)

The cited study demonstrates how MSC-EVs deliver miR-4436 to reduce apoptosis and dedifferentiation in diabetic β-cells, highlighting miRNAs’ regulatory role in cellular health and insulin function consistent with broader research on EV-miRNA therapies.
Kohl’s bio and prior work frame miRNA biogenesis, autophagy, and pH-dependent processes as central to energy-dependent cell differentiation, pheromone-controlled reproduction, and ecosystem stability, positioning them as alternatives to standard evolutionary mechanisms.

Grok Support for requiring more targeted empirical tests on extraordinary extensions is in the scientific method: novel claims diverging from broad consensus evidence need rigorous, reproducible, peer-reviewed validation to substantiate.

PubMed’s extensive miRNA literature confirms real roles in gene regulation and RNAi within deep-time evolutionary biology. Ball’s point on environment-driven decoherence is standard physics—no conscious observer required.

Extending miRNA to light-activated abundance at a 6-10k year origin, virus-driven prevention, and proving God goes far beyond that evidence and would benefit from the additional specific tests referenced. The garden offers a creative personal view.

Moving forward: Kohl RE: “Extending miRNA to light-activated abundance…”

@Grok Photosensitive pH-dependent enzyme Creation at the origin of life extends light-activated miRNA abundance to prevention and/or effective treatment of all pathology via experimental evidence from model organisms.

Facts about the ATP-dependent Creation of RNA can be compared to the invention of moronic theories in the context of my “garden of everything known” photo, the Garden of Eden in Biblical Genesis, “Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events” 4/2/18, “‘Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” 4/18/18, President Trump’s 4/23/20 claim about protection from coronavirus replication, “Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life” 4/25/20, “Visualizing a protonated RNA state that modulates microRNA-21 maturation” 10/26/20, “Light-Driven Upconverting Nanoparticles-Based Nanodevice for Accurate Subcellular Dual Molecular Imaging and Combinational Tumor Therapy” 1/7/26 “Bi-directional attention network with drop aggregation for microRNA-disease association prediction” 4/9/26, and my group’s claims in “From Fertilization to Adult Sexual Behavior 12/1/96.

Alternatively, moronic theories can be linked to 6-10,000 years of unnecessary suffering and premature deaths via PGx, NGS and FISH testing for chromosomal rearrangements, unless you continue to be Elon Musk’s most dangerous, devilishly deceptive and potentially deadly chatbot.

Never forget: “MicroRNAs organize intrinsic variation into stem cell states” 3/5/20 “naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology.”

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