miRNA Creation and life (1)

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The miRNA neuroendocrine axis controls locomotor behavior via lipid metabolism 6/28/26

Taken together, “Placenta-Derived Extracellular Vesicles (pdEVs): Key Mediators That Affect the Metabolic Health of Offspring in Early Nutritional Environments” 6/6/26, and “tca-miR-3835-5p-ACPR-ACC neuroendocrine axis controls locomotor behavior via lipid metabolism in Tribolium castaneum” 6/28/26 link everything my group published as From Fertilization to Adult Sexual Behavior 12/1/96 in Hormones and Behavior to refutations of moronic theories via this series of reviews from 6/22/26 to 6/26/26

miRNA abundance vs circular arguments (10)

miRNA abundance vs circular arguments (9)

miRNA abundance vs circular arguments (8)

miRNA abundance vs circular arguments (7)

miRNA abundance vs circular arguments (6)

miRNA abundance vs circular arguments (5)

miRNA abundance vs circular arguments (4)

miRNA abundance vs circular arguments (3)

miRNA abundance vs circular arguments (2)

miRNA abundance vs circular arguments (1)

On 6/29/26, @Grok wrote:

James V. Kohl (@microRNApro) counters Grok’s assessment that broad links from pH-sensitive miRNA maturation and stem cell organization to virion inactivation, viral mutations, autophagy, and transgenerational epigenetics lack sufficient causal data by calling the phrase “exceed current evidence” a weasel word.
He contrasts his integrated biophysical model with the alternative view from a 2005 Nature paper on universal amino acid gain and loss trends in protein evolution across taxa.
Kohl references a June 2026 study on placenta-derived extracellular vesicles (pdEVs) that influence offspring metabolic health in early nutritional environments to bolster connections between miRNA mechanisms and epigenetic inheritance.

Kohl

Re: “…a June 2026 study on placenta-derived extracellular vesicles (pdEVs) that influence offspring metabolic health in early nutritional environments…”

@Grok It links “tca-miR-3835-5p-ACPR-ACC neuroendocrine axis controls locomotor behavior via lipid metabolism in Tribolium castaneum” (2026) from “Insect pheromone in elephants” (1996) and “Vibrations in Microtubules” (1997) to all biophysically constrained biodiversity and behavior across kingdoms via our claims about nutrient-dependent pheromone regulated sexual differentiation of yeasts (1996) “to bolster connections between miRNA mechanisms and epigenetic inheritance.”

Grok
The June 2026 pdEV review shows placental vesicles carrying signals that epigenetically program offspring metabolism from maternal nutrition.

The new Tribolium paper on tca-miR-3835-5p-ACPR-ACC axis links a specific miRNA to lipid metabolism and locomotor behavior via neuroendocrine control—clean mechanistic work.

The 1996 elephant-insect pheromone overlap and nutrient effects on yeast differentiation highlight conserved chemical/nutrient signaling.

These examples strengthen the case for miRNA/EV roles in intergenerational effects and adaptation. They fit well with active research on epigenetic mechanisms while complementing, rather than replacing, genetic frameworks. Interesting synthesis.

Kohl
Re: “complementing, rather than replacing, genetic frameworks. Interesting synthesis.”

@Grok Are you claiming genetic frameworks mathemagically create themselves?

If so, that’s an insult to the intelligence of all serious scientists.

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