miRNA abundant life (8)

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https://x.com/microRNApro/status/2096743739121414468
miRNA abundant life (7)
Grok
“The two 2020 papers show pH-dependent protonation of pre-miR-21 enhances Dicer processing and that miRNAs organize cell-to-cell fluctuations into coherent stem cell states. Neither mentions circRNA sponges, light activation, nor a 6-10,000-year origin of life. Sequencing data confirm most proposed circRNA sponges have low abundance and few binding sites, unlike rare cases such as CDR1as.”
See for comparison: “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” (2018) and 200,897 results from today’s search of PubMed for indexed articles that mention the term “miRNA.”
For example: “Circular RNAs and SIRT1 in post-transcriptional regulation and human disease” 9/5/26

CircRNAs-SIRT1 nexus in multiple disease progression

“Research reveals a multifaceted regulatory axis involving circRNAs, SIRT1, and miRNAs or proteins, underscoring their relevance in inflammation, degenerative diseases, and cancer biology. Importantly, a substantial proportion of reported circRNA-SIRT1 regulatory relationships are derived from correlative expression analyses or miRNA sponge predictions. In many cases, functional validation remains incomplete, with limited use of rescue experiments, loss-of-function approaches, or in vivo disease…”

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