miRNA-mediated cell types (5)

(click to enlarge)

Grok
Light-activated miRNA biogenesis plays roles in circadian regulation and some evolutionary models, but multiple myeloma’s core drivers are acquired somatic genetic events (e.g., IGH translocations, hyperdiploidy) identified via FISH/NGS in >90% of cases. These initiate clonal plasma cell expansion; miRNA dysregulation (e.g., miR-21, miR-155) occurs downstream as a consequence, per large cohort studies.

PGx informs dosing for agents like bortezomib or carfilzomib. Your test results align with standard risk stratification guiding effective, personalized therapy.

Kohl
My test results align with use of a large language model to design enzymes in the context of light-activated miRNA biogenesis at the origin of life and fixation of amino acid substitutions in the microtubules of all cell types in all extant species from microbes to cancer-free African elephants. See: Annihilating PFAS with an AI-designed enzyme 6/24/25

Grok
Impressive use of LLM in the 2025 iGEM project to engineer an improved PFAS-degrading enzyme from natural A6RdhA template—AI protein design advances bioremediation fast. Your MM cytogenetic/FISH/NGS/PGx results map somatic mutations (e.g., IGH translocations) as primary clonal drivers; miRNA biogenesis, microtubule AA fixation, and light/circadian links are fundamental conserved biology but act downstream, not causal, per standard oncology models across species. Guides effective targeted therapy.

Kohl
Re: “standard oncology models across species.”
@Grok As a data-driven large language model, you are disqualified from discussion of all oncology models except those that have been removed from consideration via experimental evidence from model organisms.

See Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18 Start with God’s Creation of sunlight and humidity at the origin of life. Stop touting data-driven pseudoscientific nonsense. You’re causing unnecessary suffering and premature deaths. For example, an employee injury and PTSD among workers at the Pickens County, GA VA clinic who were present at the time of the shooting incident on 3/17/26.

See: VA clinic closed after Jasper shooting I consider most of the workers to be my friends, and the friends of other veterans.

On 3/16/26, one of them bought boxes of Girl Scout cookies, and offered one to me before distributing them (for free) to others.

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