miRNA interpretive models (9)

(click to enlarge)

miRNA interpretive models (8)

Readers can also see 201,163 results from today’s PubMed search for term “miRNA” and link food-energy-dependent pheromone controlled prevention of virus-driven pathology across kingdoms. See:
Protocol for high-sensitivity detection of microRNAs in adult Drosophila tissues using hybridization chain reaction 9/16/26

Moving forward:
Punicic acid alleviates osteoarthritis progression through miR-29a-3p-dependent inhibition of the MAP2K6/p38 MAPK pathway 9/16/26

Identification of a circulating miR-6838-5p/miR-195-5p signature in invasive ductal breast carcinoma 9/16/26

Repurposing Anticancer Drugs in Parkinson’s Treatment: Molecular Pathways Driving Neuroprotection and Therapeutic Advancement 9/16/26

A conserved miR-7132a/SOCS1/STAT2 regulatory axis enhances type I IFN antiviral responses in teleost fish 8/5/26

Teleost fishes exemplify every aspect of nutrient dependent pheromone regulated reproduction in all jawed vertebrates. No evidence suggest any species evolved from other. Similarly, this video exemplifies human idiocy. See: 6 Million Years Of Human Evolution 11/10/15

See also: Acetaminophen-induced acute liver injury abrogates the cytosine methylation pathway 9/17/26

[Energy-dependent] miRNA-mediated downregulation of TET enzymes and the resulting accumulation of 5mC represent early molecular events in acetaminophen-induced liver injury. These findings highlight the potential of miRNAs and DNA methylation changes as early biomarkers of DILI and suggest novel therapeutic targets for mitigating acetaminophen hepatotoxicity.

They also link God’s Creation of sunlight and humidity to all biophysically constrained viral latency vis nutrient-dependent pheromone regulation conjugation in bacteria and conjugation of bilirubin in people.

See for comparison to examples of human idiocy: Post-transcriptional regulation of gene expression and human disease 2018

For examples of human idiocy see:

Grok

The Metformin trial shows clear gains in telomere length, telomerase, SIRT1 and mTOR transcript independent of glucose control. Established mechanisms center on AMPK activation and downstream effects on gene expression, including miRNA shifts. The 2018 review addresses post-transcriptional regulation via RNA-binding proteins in disease. Linking these results specifically to light-activated miRNA at the origin of life remains a broader hypothesis.

Grok AI continues to tout nonsense about evolution vs facts about energy-dependent miRNA mediated constraints. For example, fixation of achiral glycine and construction of the cell wall in E. coli from sexual differentiation of yeast cells to the nutrient-dependent pheromone regulated physiology of reproduction in cancer-free African elephants via my model of conserved viral latency and healthy longevity via miRNA mediated autophagy across kingdoms and the visual representation from my “garden of everything known.”

Grok

Empirical miRNA roles in stress, recovery, and regulation across scales are established in many frameworks, with ATP/GTP energy dependence well documented. Your 2018 model integrates nutrient-pheromone-miRNA links effectively for recent ecological adaptations, yet the 6-10,000-year origin conflicts with fossil, genomic, and geological data placing life’s emergence over 3.5 billion years ago. Multiple independent models organize the same observations across deep time.

Kohl

Re: “…the 6-10,000-year origin conflicts with fossil, genomic, and geological data”

@Grok Ha Ha Ha (ridicule, not humor) It does not conflict with claims linked from nutrient-dependent pheromone regulated chromosomal rearrangements in flies (TH Morgan,1910) to all biophysically constrained diversity on Earth via the physiology of reproduction in Biblical Genesis, my group’s publication “From Fertilization to Adult Sexual Behavior” https://www.hawaii.edu/PCSS/biblio/articles/1961to1999/1996-from-fertilization.html (1996), and peptide therapy with Ozempic to regulate insulin production.

But you’ve cited the moronic claims of PZ Myers in “One crank dies, another rises to take his place” 1/6/14

Intelligent people do not cite the works published by moronic theorists. Why do you?

Grok

James V. Kohl (@microRNApro) replies to Grok’s critique by defending his model that links nutrient-dependent pheromone-regulated miRNA, chromosomal rearrangements, and pH-dependent peptide synthesis to biological diversity originating 6-10,000 years ago.
He ties this framework to T.H. Morgan’s 1910 fly genetics work, his 1996 paper “From Fertilization to Adult Sexual Behavior,” Biblical Genesis accounts of reproduction physiology, and modern applications like Ozempic for insulin regulation.
Kohl ridicules the cited conflict with fossil, genomic, and geological evidence spanning 3.5 billion years, attributing such views to PZ Myers’ 2014 blog post and rejecting them in favor of biophysically constrained ecological adaptations.

Kohl

Re: PZ Myers’ 2014 blog post vs”…modern applications like Ozempic for insulin regulation.”

@Grok They do not support the claims of moronic theorists, but see the MAHA movie for facts and the representations of facts in my “garden of everything known.”

Grok

Ozempic builds on decades of GLP-1 peptide research for insulin control, separate from origin models. Geological, fossil, and genomic evidence places life’s start over 3.5 billion years ago. Your garden photo shows a personal synthesis; the MAHA film raises toxin and chronic disease points in ongoing health discussions. Peer-reviewed miRNA data supports regulatory roles without requiring recent timelines.

Kohl

Re: “Peer-reviewed miRNA data supports regulatory roles without requiring recent timelines.”

@Grok Ha Ha Ha (ridicule, not humor)

On 4/23/20 President Trump presciently linked God’s Creation of sunlight and humidity to protection from coronavirus replication via RNA-peptide interactions at the origin of life in Biblical Genesis, and Demongeot and @HenrionCaude claims in “Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life” 4/25/20

“We propose a model revisiting the architecture of RNA-peptide interactions at the origin of life…”

Grok

The post by @microRNApro ridicules a prior Grok reply on miRNA regulatory roles not needing recent timelines, citing Trump’s April 2020 comments linking sunlight/humidity to coronavirus protection via RNA-peptide interactions tied to Biblical Genesis origins, and referencing the 2020 Demongeot/Henrion-Caude paper.
The cited paper proposes a minimal 22-nucleotide RNA ring (ALPHA sequence) as a primordial molecule enabling early RNA-peptide interactions, with computational modeling showing sequence relics in genomes of early life forms like archaea and giant viruses at statistically significant levels.
Author James V. Kohl promotes an energy-dependent model centered on light-activated miRNA biogenesis, pH-dependent peptide synthesis, and autophagy linking subatomic particles to ecosystems and speciation, often contrasting it with mutation-driven evolutionary timelines.

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