miRNA vs Grok’s devilish deception (5)

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miRNA vs Grok’s devilish deception (4)

Source: Gene body methylation suppresses intragenic transcription and permits epigenetic inheritance in a cnidarian, Nature Ecology & Evolution, June 2, 2026.”

Reported at microRNApro.com on 6/8/26 in Kohl’s miRNA model vs the VA & Grok (7)

See also: MiRNAs in hyperglycemia-induced metabolic memory: established mechanisms and emerging nuclear activation concepts 6/19/26

“…microRNAs (miRNAs), contribute to hyperglycemia-induced metabolic memory through the epigenetic regulation of gene expression…nuclear-activating miRNAs (NamiRNAs)…interact with enhancers and potentially activate gene transcription, representing an emerging mode of nuclear miRNA function that remains to be validated…”

The energy-dependent mode of nuclear miRNA function did not automagically emerge from the cosmic void, and it did not mathemagically link the evolution of pond scum to people.

Life is energy-dependent and miRNA-mediated. Your failure to connect facts from PGx, NGS and FISH testing may continue to be the cause of all unnecessary suffering and premature deaths.

Hate me and President Trump for telling the truth about protection from replication of viruses. But first, see: “From Fertilization to Adult Sexual Behavior” https://www.hawaii.edu/PCSS/biblio/articles/1961to1999/1996-from-fertilization.html (12/1/96 What don’t you believe about God’s “conditions of life?” Live every day with the belief that there may be no tomorrow, in case tomorrow never comes.

See also: Understanding and accounting for relational context is critical for social neuroscience (3/25/14) Part of a research article on “What determines social behavior? Investigating the role of emotions, self-centered motives, and social norms.”

THESE COMMENTS WERE REMOVED

1)
James Vaughn Kohl “New data on how genetic predispositions are epigenetically linked to phenotypically distinct neuroanatomy and behaviors is provided in the honeybee model. Across-species comparisons from insects to vertebrates clearly show that the epigenetic influence of food odors and pheromones continues throughout the life of organisms that collectively survive whereas individuals do not. These comparisons also attest to the relative salience of sensory input from the rearing environment. For example, when viewed from the consistency of animal models and conditioned behaviors, food odors are obviously more important to food selection than is our visual perception of food. Animal models affirm that food odor makes food either appealing or unappealing. Animal models reaffirm that it is the pheromones of other animals that makes them either appealing or unappealing.

Socioaffective neuroscience and psychology may progress more quickly by keeping these apparent facts in mind: Olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans (Keller et al., 2007; Kohl, 2007; Villarreal, 2009; Vosshall, Wong, & Axel, 2000).”

— Kohl, JV (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors Socioaffective Neuroscience & Psychology 3/15/12

17 Apr 2014 at 03:07am

2)
George F R Ellis This is absolutely correct and forms part of the larger concept that top-down causation is a key factor not just in the way the brain works but in broader contexts in biology and even physics. This is explored here: 25 Apr 2014 at 07:49am

3)
James Vaughn Kohl Thanks for commenting and calling attention to the background work that many seem to have missed.

To what should we attribute the failure of evolutionary theorists to consider the role of physics and chemistry in the molecular biology that links morphological and behavioral phenotypes in species from microbes to man via conserved molecular mechanisms, which link the epigenetic landscape to the physical landscape of DNA in all organized genomes? Are the scientific facts too difficult to grasp, or are they simply being ignored?

Note, some discussion of where your efforts have led occurred here: ‘A Challenge to the Supremacy of DNA as the Genetic Material’ after Ricki Lewis noticed the publication by Annila and Baverstock: http://blogs.plos.org/dnascience/2014/03/20/challenge-supremacy-dna-genetic-material/

Clearly, however, we have evidence in that discussion and many other discussions that theorists would rather avoid learning anything new than acknowledge the recent assertion that: “If you learnt evolutionary biology and genetics a decade or more ago you need to be aware that those debates have moved on very considerably, as has the experimental and field work on which they are based.” Neo-Darwinism, the Modern Synthesis and selfish genes: are they of use in physiology?

25 Apr 2014 at 12:51pm

4)
George F R Ellis Denis Noble has written some excellent material along these lines, see http://www.musicoflife.co.uk/ (both the book, and the discussions there where he answers his critics) as well as that article

25 Apr 2014 at 04:20pm

5)
James Vaughn Kohl Thanks again. Timothy W. Bredy’s group just made a giant step forward from ‘Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation‘

With publication of ‘Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation‘ they bring to bear what is currently known by you and others, like Denis Noble, about biophysical constraints on ecological adaptation. The constraints have been ignored by theorists who seem not to realize that the ‘music of life’ is nutrient-dependent. There is no orchestration by mutations — despite the claims of theorists.

For those who have not followed the information on Tet-mediated changes in cell types associated with 5 hmcs, cell type differentiation is clearly nutrient-dependent, which means that species diversity is nutrient-dependent and pheromone-controlled.

For those who have followed the information on Tet-mediated changes, you may want to see “A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution” 11/30/12

I mention that since no one would review my 3/13/14 submission on nutritional epigenetics — even though it was an invited review based on my publication last year of ‘Nutrient-dependent/pheromone-controlled adaptive evolution: a model‘

29 Apr 2014 at 12:30pm

6) George F R Ellis Great links, thanks. I’m intrigued by your work on pheromones. It is just possible it might relate to the issue of primordial emotional systems, see Affective Neuronal Selection: The Nature of the Primordial Emotion Systems 1/8/13

30 Apr 2014 at 06:11am

7)
James Vaughn Kohl It’s interesting to look at how our works fit, which they must do if our findings correctly represent biophysically constrained ecological adaptations manifested in morphological and behavioral phenotypes. Others are quickly eliminating any perceived incongruities. For example, see: Maternal nutrition at conception modulates DNA methylation of human metastable epialleles 4/29/14. This takes physics and chemistry to the one-carbon metabolism level of DNA methylation, which links ecological variation to ecological adaptations via micronutrients and macronutrients.

Since you are familiar with Panksepp’s works, I will note that my group won the seminal award in 2001 that his group won in 2002 . See Human pheromones: integrating neuroendocrinology and ethology and Comparative approaches in evolutionary psychology: molecular neuroscience meets the mind. Evolutionary theorists have since ignored or denied the role of nutrient-dependent species-specific pheromone production, which controls the physiology of reproduction, and continued to tout their ideas about mutations, natural selection and evolution.

Here we are more than a decade later and others are just now learning that the molecular mechanisms of signaling and sensing are conserved across species from yeasts to humans, which means the conserved molecular mechanisms must be the basis for emotional systems. At least one Nobel Laureate already has attested to that fact. See Feedback loops link odor and pheromone signaling with reproduction. “Indications that GnRH peptide plays an important role in the control of sexual behaviors suggest that pheromone effects on these behaviors might also involve GnRH neurons.” (p 683).

Start with yeasts: Signaling Crosstalk: Integrating Nutrient Availability and Sex (2/24/14) The nutrient-dependent production of the alpha mating pheromone exemplifies cell type differentiation at the advent of sexual reproduction, and when concentrated it elicits a luteinizing hormone (LH) response from the cultured pituitary cells of a mammal, the rat.

The mammalian GnRH-directed LH response has been the focus of my works for more than 2 decades since someone told me my mammalian model had to start with gene activation in hormone-secreting nerve cells of the brain. However, in 2010 , Richard Doty published a book and claimed that mammalian pheromones don’t exist. Simply put, they can’t — if you’re a social scientist. See: A Fear of Pheromones

30 Apr 2014 at 10:00am

8) James Vaughn Kohl Timothy W. Bredy’s group has done it again. See: Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice.

Conclusion: Experience-dependent expression of lncRNAs plays an important role in the epigenetic regulation of adaptive behavior, and the perturbation of Gomafu may be related to anxiety and the development of neuropsychiatric disorders.

The most obvious correlation with what is now being discussed in the context of top-down causation and 4-D genome make-up that changes during life history transistions is: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults. 10/16/14

It shows the difference that a single amino acid substitution can make during experience-dependent RNA-mediated life history transitions that link metabolic networks to genetic networks.

25 Feb 2015 at 08:03pm

9) James Vaughn Kohl Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice

The link from energy-dependent changes in the microRNA/messenger RNA balance to learning and memory may be the final example of top-down causation that is required to link angstroms to ecosystems via the physiology of reproduction and behavior in all living genera.

Their experimental evidence of biologically-based cause and effect appears to link the innate immune system to protection of all organized genomes from virus-driven energy theft and genomic entropy in the context of the biophysically constrained chemistry of RNA-mediated protein folding during life history transitions.

9:12 AM, 27 June 2016

George F R Ellis James Vaughn Kohl Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice
The link from energy-dependent changes in the microRNA/messenger RNA balance to learning and memory may be the final example of top-down causation that is required to link angstroms to ecosystems via the physiology of reproduction and behavior in all living genera.

Their experimental evidence of biologically-based cause and effect appears to link the innate immune system to protection of all organized genomes from virus-driven energy theft and genomic entropy in the context of the biophysically constrained chemistry of RNA-mediated protein folding during life history transitions.

UPDATE
The 10-year anniversary of my text-based conversational exchange with George FR Ellis, on 6/27/26 can be considered in the context of the past decades of pseudoscientific nonsense touted by theorists and @Grok.

See: Why the Human Genome’s Tangled Physicality May Confound AI 6/18/26

“…the processes that govern gene regulation are proving so complex that some biologists wonder whether a full understanding of it — of how the genome really works — will ever be within the grasp of our puny minds.”

A musician friend who understands the experimentally established facts from model organisms that link repetitive motion (i.e, playing guitar and barometric pressure) to the molecular mechanisms of social behavior, selectively sent me the cartoon featured in this post. He was told to start playing to increase his serotonin and dopamine levels, as he struggled with depression during his wife’s decline due to early onset dementia.

Thank God, he is not dead yet!

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