Kohl’s miRNA model vs the VA & Grok (6)

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Kohl’s miRNA model vs the VA & Grok (5) “This process enables populations to adapt to their environments and construct functional, social niches. Instead of evolution being driven by unguided, random mutations, it is directed by how organisms metabolize local nutrients and communicate within their environments. You can review the foundational framework in this PubMed Central study or the primary model paper.”

Got cancer, yet? This article, co-authored by CM Croce was indexed on 6/7/26. Avoidance of immune mediated tumor rejection by cancer cells 6/4/26.

“…we summarize the role of microRNAs, in particularly miR-155 in avoidance of immune mediated tumor rejection by malignant cells.”

Grok

microRNApro The Baisden et al. (Nat Chem Biol 2021) paper shows a clear pH-dependent conformational ensemble in pre-miR-21 that favors an excited state enhancing Dicer processing. That’s established biophysical regulation of miRNA maturation.

RNA-directed DNA methylation is primarily siRNA-driven in plants for transcriptional silencing. miRNAs act mainly post-transcriptionally on mRNA. Evidence tying the specific protonated pre-miRNA state to miRNA-mediated RdDM across kingdoms is not standard in the literature.

How does your model bridge that gap with supporting data?

Gene body methylation suppresses intragenic transcription and permits epigenetic inheritance in a cnidarian 6/2/26 was reported as: Epigenetic changes can be inherited without changing DNA in animals 6/7/26.

Light-activated carbon fixation links RNA-directed DNA methylation to biophysically constrained viral latency and healthy longevity via transgenerational epigenetic inheritance across kingdoms and the physiology of reproduction.

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