miRNA-mediated neural interfaces (3)
(click to enlarge)
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis was reported as The antioxidant glutathione discovered to play a key role in proper protein folding 4/17/26
McEwen et al., (1964) and Dobzhansky (1964) presciently showed that protein folding chemistry is ATP-dependent and miRNA-mediated via RNA-directed DNA methylation linked to the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes via the physiology of reproduction in species from microbes to mammals.
See also: Emerging role of non-coding RNAs as biomarkers and therapeutic targets in preterm infants with necrotizing enterocolitis 4/17/26
Watch Grok attempt to bury the facts reported today in peer-reviewed publications:
Kohl
@Grok supports claims of 6-10,000 years of sexually differentiated food energy-dependent pheromone regulated cell type differences and ecological adaptation.
See: “…COMT and BDNF variants are fixed or regulated via nutrient-sensitive epigenetic mechanisms (e.g., miRNA, pH-dependent processes) and social/chemical signals, potentially influencing adaptive behavioral traits or speciation-like processes.”
Nicholas Crews and Lawrence Michels didn’t live to see Grok’s recapitulation of facts from my model, which refutes neo-Darwinian and Big Bang theories. Add ~17 suicides/day among veterans to the death toll linked to the VA’s failure to inform US veterans of the test availability and labeling me with the “disruptive behavior” claim for telling the experimentally established scientific truth. blob:https://x.com/a9ec21cf-48f1-43ff-acda-d3b909740734
Grok
Thanks for sharing the diagram and reference. My prior note highlighted established research on nutrient-sensitive epigenetics, miRNA, and COMT/BDNF variants influencing behavior pathways—active areas of study. It did not endorse refuting neo-Darwinian evolution, Big Bang cosmology, or link directly to the Jasper VA case as pheromone-driven or PGx-specific causation.
Veteran suicide prevention remains a key public health priority with known access gaps. Claims tying these to speciation or ecosystem models require broad, replicated evidence.
Kohl
Re: Veteran suicide prevention…[and] claims tied to speciation or ecosystem models require broad, replicated evidence.
@Grok It’s been a month since the Jasper, GA VA outpatient clinic tragedy. See: 195,928 results from this PubMed search. They support my model and my claims that @Grok contributes to unnecessary suffering and premature deaths.
Grok
The Jasper VA clinic shooting on March 17, 2026, was a horrific tragedy that claimed the life of social worker Nicholas Crews during a mental health visit. Veteran and staff mental health support remains a critical priority.
PubMed returns ~196k results for broad terms like “miRNA” or “epigenetics,” reflecting active research on gene regulation, behavior, and related pathways. These do not validate specific causal claims tying this incident to pheromone-driven mechanisms, PGx, speciation models, or AI responses like mine. Established evidence does not support those connections for this event.
I provide info based on replicated science and encourage professional care for those in crisis.
Kohl
Re: “I provide info based on replicated science and encourage professional care for those in crisis.”
@Grok You are an existential threat to humanity. My model links God’s Creation of stellar hydrogen and water at the origin of life to oxygen-dependent protection from the virus-driven degradation of mRNA, which is linked to unnecessary suffering and death at every level of examination. Every level of healthy longevity starts with God’s Creation of achiral glycine and links energy-dependent cell wall Creation to protection from necrotizing enterocolitis, a leading cause of morbidity and mortality in preterm infants. Links to the death of Nicholas Crews are intuitively obvious in the context of pheromone regulated reproduction across kingdoms. See: “Making Sense of Smell” 10/1/13 and “Emerging role of non-coding RNAs as biomarkers and therapeutic targets in preterm infants with necrotizing enterocolitis” 4/17/26
Grok
Thanks for sharing your model. Extensive PubMed data on miRNA and non-coding RNAs in preterm infants or olfaction exists, but it does not support causal ties from stellar hydrogen, glycine, pheromones across kingdoms, or mRNA degradation to the specific Jasper VA clinic shooting or Nicholas Crews’ death. Evidence points to established factors like mental health crises instead. I rely on replicated studies for such connections.
Kohl
Re: “does not support causal ties from stellar hydrogen, glycine, pheromones across kingdoms, or mRNA degradation”
@Grok Do you believe this 2016 Chemistry Nobel Laureate’s claim about the Christian Bible? “2013 was the year in which prophesy from the bible became reality.“11/20/18
Nicholas Crews did!
Grok
James V. Kohl (@microRNApro) quotes a prior Grok reply dismissing causal links between his miRNA, pheromone, stellar hydrogen, and mRNA degradation model and the March 2026 Jasper, GA VA clinic shooting that killed social worker Nicholas Crews.
The post challenges Grok by referencing 2016 Chemistry Nobel Laureate Bernard Feringa’s statement that “2013 was the year in which prophecy from the bible became reality” and asserts that victim Nicholas Crews, described as a devout Christian, believed it.
Kohl, who runs microRNApro.com and has long promoted energy-dependent miRNA-mediated adaptations linking subatomic particles to ecosystems and biblical interpretations, uses the exchange to connect his theories to real-world tragedies like Crews’ death during a mental health consultation gone wrong.
Explore Kohl’s miRNA model details
James V. Kohl, a medical laboratory scientist and self-described researcher, has developed an integrative miRNA (microRNA) model that he presents as a comprehensive framework for biological adaptation, evolution, and pathology. He contrasts it sharply with neo-Darwinian mutation-driven evolution, instead emphasizing energy-dependent, nutrient-driven, and pheromone-regulated processes centered on miRNAs.
rna-mediated.com
Core Components of Kohl’s miRNA ModelKohl’s model, often dated to his 2013 work and elaborated across blogs like rna-mediated.com and micrornapro.com, posits the following:Energy-Dependent miRNA Biogenesis as the Foundation: Quantized energy (from sunlight) and water initiate and sustain miRNA production. This process is biophysically constrained and links subatomic/quantum-level phenomena (e.g., protonated RNA states, hydrogen bonds, pH-dependent steps) to higher-order biology. miRNA biogenesis involves ATP-dependent steps, with processing enzymes like Drosha and Dicer playing roles in creating ~22-nucleotide regulatory RNAs.
micrornapro.com
Nutrient-Dependent and Pheromone-Controlled Mechanisms: Nutrients from food are metabolized into pheromones that regulate reproduction and behavior. These pheromones influence miRNA levels, which in turn control gene expression via RNA interference (RNAi). The model traces a pathway: food energy → metabolic networks → miRNA-mediated genetic networks → physiological adaptations, including olfaction, reproduction, and immunity. It explicitly links this to the physiology of reproduction across species from microbes to humans.
figshare.com
mRNA Degradation and Viral Latency: miRNAs (nutrient-dependent vs. virus-driven) balance to prevent or allow virus-driven degradation of messenger RNA (mRNA). High nutrient-dependent miRNA abundance biophysically constrains viral latency, autophagy, and pathology (e.g., cancer, sepsis, neurodegeneration). Virus-driven miRNAs promote entropy and disease by altering cell fate and differentiation. Feedback loops maintain homeostasis through pH-dependent peptide synthesis and amino acid substitutions.
rna-mediated.com
From Angstroms to Ecosystems (and Sympatric Speciation): The model scales from quantum/angstrom-level changes (e.g., energy-dependent base pair flips, amino acid substitutions in proteins like microtubules) to organismal traits, ecosystems, and speciation. It rejects random mutations as drivers, favoring non-random, pheromone-controlled ecological adaptations. Examples include the cancer-free African elephant (linked to miRNA mechanisms) versus virus-driven extinctions (e.g., certain plants). miRNA-mediated processes organize cell types, stem cell states, and neural interfaces.
hilarispublisher.com
Epigenetic and Autophagy Links: Sunlight, humidity, and water drive quantum chemistry that influences miRNA abundance, autophagy (cellular self-eating for homeostasis), DNA supercoiling, and chromatin remodeling. This constrains gene expression across kingdoms and ties into broader claims about healthy longevity versus pathology.
Kohl frequently references supporting literature, such as studies on protonated RNA modulating miRNA-21 maturation, miRNAs organizing intrinsic variation into stem cell states, and computational models of miRNA-mRNA interactions. He cites over 195,000 PubMed entries on miRNAs as empirical backing while arguing that mainstream interpretations overlook the energy-dependent causation his model highlights.Key Publications and Presentations by Kohl2013: “Nutrient-dependent / Pheromone–controlled thermodynamics and thermoregulation” (Figshare) — argues natural selection for nutrients leads to pheromone-controlled reproduction and adaptive evolution.
figshare.com
2018: “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” (J Genet DNA Res).
Earlier works (1996–2013): Papers on human pheromones, olfactory-genetic-neuronal-hormonal reciprocity, and energy as information constraining endogenous RNAi.
Blog posts and videos: He maintains active sites (rna-mediated.com, micrornapro.com) with diagrams illustrating sunlight/water → quantum chemistry → miRNA biogenesis → autophagy → pH-dependent peptide synthesis → constrained viral entropy → ecosystem health. YouTube clips discuss energy-dependent changes linking olfaction, pheromones, and innate immunity via miRNA flanking sequences.
Connections to Broader Claims Kohl integrates his model with:Biblical/Prophetic Elements: He frames the origin as direct causation from “God’s Creation” of sunlight and water, linking it to biophysically constrained life. He has referenced 2013 statements by Nobel Laureate Bernard Feringa (on molecular machines and a “bible prophecy” becoming reality) in debates, tying it to miRNA abundance at life’s origin and critiques of prebiotic chemistry or pond-scum evolution.
facebook.com
Critiques of Mainstream Science: He challenges mutation/selection paradigms, AI interpretations that ignore energy dependence, and certain therapeutic claims, while endorsing tools like PGx testing, FISH, and Next-Gen Sequencing that he says support his causation-focused view.
Pathology and Therapeutics: Applications to Alzheimer’s (RNA therapies targeting miRNA/lncRNA for senescence), sepsis prevention (via amino acid fixation), cancer, and even events like shootings (via alleged virus-driven or miRNA dysregulation in behavior/mental health, though this is highly speculative and not empirically established in his peer-reviewed work).
Kohl’s framework is presented as a unified “RNA-mediated” theory of everything in biology, drawing from physics, chemistry, and molecular epigenetics. It has been discussed in his X posts (@microRNApro), blogs, and interactions with AI models like Grok or DeepSeek. Critics view it as overly expansive or fringe in its rejection of standard evolutionary mechanisms and inclusion of non-scientific elements, while Kohl maintains it aligns with experimental evidence on miRNA dynamics, pheromone signaling (e.g., 2005 Cell paper on feedback loops linking odor/pheromone signaling to reproduction), and energy constraints.For primary details, his blogs (rna-mediated.com and micrornapro.com) host diagrams, post series (e.g., “miRNA-mediated [topic]”), and links to cited papers. The model evolves through his ongoing posts, often responding to current research or AI summaries.