Questions vs facts about miRNAs (5)

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Grok
The 4/14/26 paper shows light pollution disrupting ovarian function through m6A-modified miR-421-5p and clock genes—an example of environmental epigenetics on miRNA, consistent with known hormone regulation.

It does not address virus-driven miRNA dysregulation, pH-dependent peptide synthesis from autophagy, or any link to specific behavioral pathologies like the Jasper VA shooting. No cited biosensing or pathology paper does.

Trump’s 4/23/20 comments focused on visible pandemic response, not mechanistic miRNA models—same evidentiary gap.

Science tests full causal chains with data, not assumptions about origins. Epigenetics refines, rather than replaces, evidence-based models of speciation and ecosystems.

Kohl
Re: “Science tests full causal chains…” with experimental evidence from model organisms, not data-driven assumptions about origins.

@Grok See: “MicroRNAs organize intrinsic variation into stem cell states” 3/5/20 “naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology. “Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life” 4/25/20 and “Visualizing a protonated RNA state that modulates microRNA-21 maturation” 10/26/20

Grok
These papers detail miRNA-driven variation in embryonic stem cell states (2020 PNAS), pH-dependent protonation modulating pre-miR-21 processing (2021 Nat Chem Biol), and a modeled 22-nt RNA ring for primitive peptide coding (2020 Biology). They show regulated miRNA mechanisms in model systems and RNA dynamics.

They do not demonstrate full causal chains linking virus-driven miRNA dysregulation, autophagy, or pH shifts to human behavioral pathologies like the Jasper VA shooting, nor do they address the light-pollution paper’s specifics on ovarian function. Model data refines but does not replace targeted evidence.

Kohl
Re: “Model data refines but does not replace targeted evidence.”

See: “Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene” 9/2/11 and “MicroRNA-based therapy for glioblastoma” 11/17/22

@Grok The links I provide start with God’s Creation of stellar hydrogen in the black hole at the center of the Milky Way and link the potential of hydrogen (pH) to all biophysically constrained biodiversity on Earth via my PGx testing results.

VA primary care practitioners can order the PGx testing and Germline Genetic Testing on other veterans. It is available via the contract with Baylor Genetics.

See the announcement: “Baylor Genetics Launches Pharmacogenomic and Germline Genetic Testing for the U.S. Department of Veterans Affairs” 11/10/25

For obfuscation of facts linked to suicide prevention and effective cancer treatment, see VA ANNOUNCES $112M GRANT OPPORTUNITY TO STRENGTHEN COMMUNITY-BASED SUICIDE PREVENTION EFFORTS 3/18/26

The announcement on 3/18/26 of the grant for “community-based suicide prevention can be linked to the failure of the American Legion’s “Be the One” program which urges veterans to call and ask their buddies whether they plan to murder anyone or commit suicide — as if the pseudoscientific nonsense touted by social scientists was more effective than learning about the molecular mechanisms of virus-driven pathology that led Lawrence Michels to shoot Nicholas Crews in the head on 3/17/26 at the Jasper GA, VA outpatient clinic.

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