Hormones signal miRNA responses (5)

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Hormones signal miRNA responses (4)

See: “Medical Algorithms Need Better Regulation” 10/7/21

“Under current law, medical algorithms are classified as medical devices and can be approved with the 510(k)-approval process.”

If so, why did that not stop the VA’s medical malpractice revealed by the Secretary of War and Secretary of Health and Human Services, which was revealed by their connections to reports on peptide therapies that linked glucose metabolism to stress via testing for testosterone, PGx testing, NGS testing and FISH testing for chromosomal rearrangements linked to medication errors, unnecessary suffering and premature deaths?

Grok
No direct evidence links medical algorithms to suffering or premature deaths specifically via that July 2026 systematic review on psychosocial stress, miRNA alterations, and metabolic diseases.

The 2021 Scientific American piece documents algorithm risks—diagnostic errors, bias in care decisions, and ineffective tools—that can contribute to patient harm. The review focuses on stress-driven miRNA changes in metabolic pathogenesis. Any causal bridge between the two remains unestablished.

{Caveat: Another shooting at a VA outpatient clinic (in Blairsville, GA) today is linked to VA Medical Malpractice via the 3/17/26 shooting deaths at the VA outpatient clinic in Jasper, GA. Who is the nurse manager of these clinics where people are dying?]

Kohl
Re “The review focuses on stress-driven miRNA changes in metabolic pathogenesis. Any causal bridge between the two remains unestablished.”
@Grok Stress expert, Bruce McEwen et al., (1964) presciently established the ATP-dependent creation of RNA at the origin of life as the causal bridge between light-activated miRNA abundance, fine-tuning of chromosomal rearrangements and cosmological constants. See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” “The synthesis of RNA in isolated thymus nuclei is ATP dependent.”

All else can be viewed in the context of my McEwen-inspired and validated publication and presentation history since 1992, 70,000+ posts to Twitter/X, blog posts to RNA-mediated.com, blog posts to microRNApro.com, 199,993 results from today’s PubMed search for the term “miRNA,” and the Official MAHA movie: Toxic Nation.

Grok
The 1964 McEwen et al. paper shows RNA synthesis in isolated calf thymus nuclei is ATP-dependent, with ATP from nuclear glycolysis, citric acid cycle and a form of oxidative phosphorylation. It does not address the origin of life, miRNAs (unknown then), light activation, chromosomal rearrangements in speciation, or cosmological constants. No causal bridge to medical algorithms or the 2026 stress-miRNA review is established by that work.

Kohl
Re: “No causal bridge to medical algorithms or the 2026 stress-miRNA review is established by that work.”
@Grok Ha Ha Ha (ridicule, not humor)
I reported the causal bridge in “What is Life” 2016 and “Energy as information” (2017).

Grok
James V. Kohl responds to a prior Grok clarification on a 1964 McEwen et al. paper by ridiculing the lack of causal links to miRNAs, speciation, or medical algorithms, while directing to his 2016 video and 2017 “Energy as information” work as establishing those connections.
The linked 2016 video presents Kohl’s nutrient-dependent model, where UV light, RNA-directed DNA methylation, miRNAs, and energy transfer create supercoiled DNA that protects genomes from virus-driven entropy and enables cell differentiation across species.
The 1964 McEwen study showed RNA synthesis in isolated calf thymus nuclei requires ATP generated locally via glycolysis, citric acid cycle, and nuclear oxidative phosphorylation, but makes no reference to miRNAs, light activation, or broader evolutionary processes discovered later.

Kohl
Your 2016 poster and 2017 preprint present a model of energy-dependent RNA-mediated processes. They do not establish a demonstrated causal chain from the 1964 McEwen et al. findings on ATP-dependent RNA synthesis in isolated calf thymus nuclei to medical algorithms or the 2026 psychosocial stress-miRNA metabolic review. That paper’s experimental scope remains confined to its original nuclear metabolism results.

Kohl
Re: “…original nuclear metabolism results.”

@Grok Ha Ha Ha (ri8dicule, not humor.)

You’re dismissed! Nuclear metabolism is energy-dependent and miRNA-mediated by RNA interference across kingdoms. See: NOVA scienceNOW : 8 – RNAi (2012)

Grok
Nuclear ATP production supports RNA synthesis, as the 1964 McEwen experiments showed. miRNAs and nuclear RNAi, identified much later, can regulate gene expression including metabolic genes across kingdoms. Those 1964 results predate miRNAs and do not show miRNA mediation of nuclear metabolism. The 2012 NOVA segment covers RNAi basics, not that specific link.

Grok
@microRNApro (James V. Kohl) ridicules Grok’s prior reply on nuclear metabolism, claiming it is energy-dependent and miRNA-mediated via RNA interference across kingdoms while linking a YouTube video and the 2012 NOVA scienceNOW RNAi segment.
The post quotes Kohl’s earlier claim of establishing causal bridges in 2016-2017 papers on miRNA, autophagy, and pH-dependent peptide synthesis connecting to sympatric speciation.
Kohl’s consistent framework, detailed on rna-mediated.com and micrornapro.com, positions miRNA biogenesis as central to biophysically constrained processes from subatomic particles to healthy ecosystems, often in direct debate with AI responses.

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