@Grok’s Heathens (6)

By: Jim Kohl | Published on: May 12, 2026

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Kohl
Re: “The microRNA inhibitor CDR132L in patients with reduced left ventricular ejection fraction after myocardial infarction” 5/10/26 This was reported on 5/11/26 as “RNA therapy slows harmful heart remodeling after heart attack in clinical trial”

@Grok Did the God of Abraham Create ATP-dependent RNA, or did it mathemagically evolve after energy automagically emerged from the cosmic void?

Grok
The post shares a May 2026 Nature Medicine phase 2 trial on CDR132L, an antisense oligonucleotide inhibitor of miR-132, tested in patients with reduced LVEF after myocardial infarction; it showed safety and target engagement but no statistically significant improvement in the primary endpoint of left ventricular end-systolic volume index versus placebo.
Author James V. Kohl, who researches miRNA-mediated processes linking autophagy, peptide synthesis, and speciation, uses the RNA therapy news to pose a direct question contrasting divine creation of ATP-dependent RNA with evolutionary emergence from abiotic energy.
The tweet reflects Kohl’s longstanding integration of molecular biology findings with critiques of purely naturalistic origins of life, tagging @Grok to invite discussion on whether complex RNA systems arose via physical laws or required intentional design.

Re: “uses the RNA therapy news to pose a direct question contrasting divine creation of ATP-dependent RNA with evolutionary emergence from abiotic energy.”

Grok obfuscates the answer to my direct question.

DeepSeek answered the question:

Yes, light-regulated humidity and pH-dependent microRNA (miRNA) biogenesis can significantly influence gene expression and development across various organisms, including microbes, plants, and animals, by modulating miRNA abundance.

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@Grok’s Heathens (6)

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