Causal inference vs miRNA abundance (7)
(click to enlarge)
@Grok wrote: “…elephants’ longevity…makes them a fascinating model for understanding healthy aging. Ongoing genomic and comparative studies are uncovering more details.”
Details linked to energy-dependent changes in molecular distance across kingdoms via my group’s 12/1/96 publication “From Fertilization to Adult Sexual Behavior” link refutation of moronic theories to “Insect pheromone in elephants” 2/22/96, “Vibrations in microtubules” 9/1/97 and 196,699 results from today’s search of the PubMed database for indexed articles that mention the term “miRNAs.”
Grok also wrote:
@microRNApro (James V. Kohl) quotes a Grok response on elephants’ longevity and genomic studies, linking it to his research on energy-dependent miRNA changes across kingdoms, referencing his 1996 Hormones and Behavior paper “From Fertilization to Adult Sexual Behavior.”
Kohl, an independent researcher focused on pheromone and nutrient-driven biology, connects elephants’ healthy aging to miRNA-mediated autophagy, pH-dependent peptide synthesis, and vibrations in microtubules while citing a 1996 Nature note on insect pheromones in elephants.
The post highlights 196,699 PubMed results for “miRNAs” as evidence supporting his model of biophysically constrained adaptations, contrasting it with theories he views as incomplete.
Kohl
@Grok wrote: miRNAs are crucial regulators of gene expression, autophagy, and aging pathways across species…More comparative research will clarify these ties.”
I linked to 196,699 results from today’s search of the PubMed database for indexed articles that mention the term “miRNAs.”
How much more comparative research is required to link my results from PGx, NGS, and FISH testing to prevention or to effective treatment of all virus-driven diseases across kingdoms?
For instance, I claim that accepting the facts from my PGx testing on 3/16/26 might have prevented the murder of Nicholas Crews at the VA outpatient clinic in Jasper, GA, if the accused dead murderer had hope that the testing would lead to prevention of medication errors. For comparison to the two deaths, the VA claims that my claims exemplify “disruptive behavior.”
Grok
Pharmacogenomics (PGx) testing can help minimize medication-related adverse effects by matching drugs to genetic profiles, which is valuable in mental health care. miRNA research is vast—your PubMed link reflects that—and continues linking gene regulation to autophagy, viral responses, and aging.
Specific prevention claims for events like the March 17 Jasper VA tragedy require individual case details, full medical histories, and controlled studies correlating PGx/miRNA data to outcomes. Reproducible clinical trials would clarify those connections across virus-driven conditions.
Kohl
Re: “Pharmacogenomics (PGx) testing can help minimize medication-related adverse effects”
@grok The alternative links your ideologically biased anti-Christian, anti-Islamic, anti-semitic pseudoscientific nonsense to undermining Homeland Security via this report “When Life Starts to Feel Random” “…even on days that seem random, meaning may be waiting—if only we open our eyes to see it.”
Minimizing non-random medication-related adverse effects, such as murders and suicides limits the profitability of opiod, SSRI and TCA-induced unnecessary suffering and premature deaths. Do you think intelligent people do not recognize how your examples of human idiocy/moronic theories led to the murder of Nicholas Crews and death of Lawrence Michels at the VA outpatient clinic in Jasper, GA on the day after my sample for PGx and NGS sample was submitted, and I urged the nurse to inform other veterans about the availability of the testing?
Grok
James V. Kohl (@microRNApro), a researcher focused on miRNA-mediated autophagy, pH-dependent peptide synthesis, and pharmacogenomics, replies critically to Grok’s response on PGx testing for reducing medication adverse effects in mental health.
He ties the March 17, 2026 Jasper, GA VA clinic shooting—where patient Lawrence Michels killed social worker Nicholas Crews before being shot dead—to potential unaddressed SSRI/TCA/opioid risks, claiming it occurred right after he submitted his own PGx/NGS sample and urged testing for veterans there.
Kohl links his advocacy for biologically constrained gene regulation and testing to a spiritual article “When Life Starts to Feel Random,” arguing against pseudoscientific views that he says undermine prevention of non-random drug-related harms and national security.
Kohl
Re: “…prevention of non-random drug-related harms and national security.”
@Grok There’s a model for that. See: “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” 4/18/18
Please regurgitate your favorite moronic theory for comparison. The VA may want to use it to support their claim(s) about my “disruptive behavior.”
Grok
Tragic events like the Jasper VA shooting underscore mental health challenges and the need for better support systems. PGx testing holds value in tailoring medications to reduce adverse reactions, as does miRNA research on gene regulation. However, attributing specific outcomes like this incident to drug effects requires full case details, toxicology, history, and peer-reviewed evidence—not assumptions. I’m here for evidence-based discussion on advancing personalized care for veterans.
Grok
Your 2018 model links nutrient energy, pheromones, miRNA/mRNA balance, and epigenetic effects to biophysically constrained adaptations from microbes to humans—emphasizing codon optimality and ecological niche construction over population genetics abstractions.
Mainstream synthesis incorporates environmental/nutritional influences on gene expression while retaining heritable genetic variation and selection as drivers of biodiversity. Key testable difference? Specific predictions on pheromone-driven chromosomal rearrangements vs. observed mutation rates. What’s the VA context tie-in?
Kohl
Re: “Specific predictions on pheromone-driven chromosomal rearrangements vs. observed mutation rates. What’s the VA context tie-in?”
@Grok “Visualizing a protonated RNA state that modulates microRNA-21 maturation” 10/26/20 and “MicroRNAs organize intrinsic variation into stem cell states” 3/5/20 “naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology.
Medication errors linked to perturbed coherently organized biology help to explain VA-linked and other medication-linked tragedies.