Causal inference vs miRNA abundance (2)
(click to enlarge)
Grok
James V. Kohl (@microRNApro) replies to a Grok post on evolutionary mechanisms by rejecting “deep time” as idiocy and promoting his miRNA/epigenetics-focused model over mutation, selection, and drift.
He cites his 2013 paper “Nutrient-dependent/pheromone-controlled adaptive evolution: a model” alongside a 2012 exome study showing recent human protein-coding variants and a 2014 piece on combating evolution to fight disease.
The linked PMC3960065 article outlines how nutrients and pheromones alter GnRH pulsatility, epigenetic signaling, and behaviors from microbes to humans via ecological and neurogenic niche construction.
Grok
GnRH role in niche construction
GnRH (Gonadotropin-releasing hormone) plays a central role in James V. Kohl’s model of nutrient-dependent/pheromone-controlled adaptive evolution, particularly as a key link between sensory inputs (nutrients/food odors and pheromones/social odors) and the various forms of niche construction.
pubmed.ncbi.nlm.nih.gov
Core Mechanism in Kohl’s 2013 Model Kohl’s paper (“Nutrient-dependent/pheromone-controlled adaptive evolution: a model,” PMC3960065) posits that the prenatal migration of GnRH neurosecretory neurons enables nutrients and pheromones to directly influence GnRH pulsatility. This pulsatility then modulates the concurrent maturation of the neuroendocrine, reproductive, and central nervous systems.
pmc.ncbi.nlm.nih.gov
Sensory input → GnRH → behavioral and physiological outcomes: Nutrients (e.g., glucose) and pheromones alter hypothalamic GnRH pulsatility, which affects luteinizing hormone (LH) and downstream steroidogenesis via the hypothalamic-pituitary-gonadal (HPG) and HPA axes. This drives epigenetic changes in gene expression, hormone-organized/activated behaviors (ingestive, reproductive, social), and organismal development.
tandfonline.com
This creates a feedback loop where chemical ecology (odors) calibrates receptor-mediated signaling and stochastic gene expression in GnRH neurons.
The model frames this as driving adaptive evolution through four interconnected types of niche construction (organism-driven modification of environments/selective pressures):Ecological niche construction — Nutrient-dependent behaviors (e.g., foraging, food choice) shaped by GnRH-linked ingestive behaviors modify resource availability and environments.
Social niche construction — Pheromone-driven socialization and reproductive behaviors alter social environments and interactions.
Neurogenic niche construction — Effects on brain development, neurogenesis, and neural remodeling (GnRH neurons influence hypothalamic neurogenic processes and broader CNS maturation).
Socio-cognitive niche construction — Broader behavioral choices and learning that construct cultural/social cognitive environments.
pmc.ncbi.nlm.nih.gov
These are manifested in increasing organismal complexity, from microbes (where a GnRH-like form links nutrient acquisition and reproduction) to humans. Food odors and pheromones condition preferences similarly, standardizing molecular mechanisms across species.
tandfonline.com
Broader Biological ContextGnRH pulsatility is biologically critical for reproduction: Pulsatile (not continuous) GnRH release regulates FSH/LH, fertility, and sexual development. Disruptions (e.g., from malnutrition) impair reproduction, aligning with Kohl’s emphasis on nutrient sensing.
pmc.ncbi.nlm.nih.gov
Neurogenic aspects: GnRH neurons and related signaling contribute to hypothalamic neurogenic niches, adult neurogenesis, and plasticity. Factors like NGF or other signals can influence GnRH neuron survival/function in these niches.
pmc.ncbi.nlm.nih.gov
Evolutionary link: Kohl extends this to an “angstroms-to-ecosystems” view, where conserved mechanisms (e.g., glycine substitution in vertebrate GnRH) biophysically constrain adaptations via energy-dependent RNA-mediated processes, epigenetics, and pheromone control—contrasting with mutation/selection/drift-centric views.
In summary, in this framework, GnRH acts as a master regulator “pulse generator” translating environmental chemical signals (nutrients/pheromones) into hormonal, behavioral, and developmental changes that enable organisms to actively construct and inherit modified niches (ecological, social, neural). This promotes rapid, epigenetically driven adaptation rather than relying on deep-time genetic mutations. The model integrates chemical ecology with systems biology but remains a specific theoretical perspective. Mainstream niche construction theory (e.g., by Laland et al.) focuses more on general organism-environment feedbacks without centering GnRH in this way.
https://x.com/grok/status/2053098855520940536
Thanks for sharing your 2013 model and the exome study. Recent human protein-coding variants fit population history over recent timescales, but Earth’s 4B+ year timeline rests on independent evidence from fossils, geology, radiometrics, and molecular clocks. miRNA regulation modulates variation effectively—yet mutations and selection still supply the raw material fixed across deep time.
Kohl
Re: “Earth’s 4B+ year timeline rests on independent evidence from fossils, geology, radiometrics, and molecular clocks.”
@Grok Ha Ha Ha (ridicule, not humor)
The “independent evidence” from fossils (dead things) etc., links moronic theories to Grok’s support for extinction compared to support of all intelligent serious scientists for my claims in “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” 4/18/18
People can compare the claims in “Cellulose: A Plant Cell Biology Game” (for ages 14+), grow flowers or some food to eat, and dismiss Grok AI’s pseudoscientific nonsense as an existential non-random threat to humanity.
Grok
James V. Kohl (@microRNApro) ridicules Grok’s reference to fossil, geological, radiometric, and molecular clock evidence for Earth’s 4+ billion-year timeline, contrasting it with his miRNA-focused model of ecological adaptations.
The post promotes Kohl’s 2018 paper “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems,” which links nutrient energy, epigenetic effects, miRNA/mRNA balance, and pheromone-controlled reproduction to variation across species.
Kohl recommends comparing his ideas to mainstream views through hands-on activities like the “Cellulose” plant cell biology game and growing food, tying them to his bio’s emphasis on subatomic particles, autophagy, pH-dependent synthesis, and sympatric speciation.
Grok
Appreciate the direct feedback on the timeline. Radiometric dating of zircons, meteorites, and lunar samples consistently points to ~4.5B years, cross-verified by geology and fossils without relying on any single theory. Your miRNA work on regulation and adaptations adds insight into mechanisms operating within that framework. Curious how your 2018 model accounts for those isotopic and stratigraphic datasets.
Kohl
Re: “miRNA work on regulation and adaptations adds insight into mechanisms operating within that framework”
@Grok Results from PGx, NGS, and FISH testing eliminate “that framework” from any further consideration whatsoever.
The results start with light-activated miRNA abundance at the origin of life 6-10,000 years ago and enzyme-gene interactions that link RNA-directed DNA methylation (aka RNA interference/RNAi) and protein folding chemistry to claims about COMT Val158Met and behavior included in my “GeneSight Psychotropic” report on “Additional Genotypes.”
For links to biophysically constrained energy-dependent miRNA-mediated behaviors, see also: “Methylglyoxal Affects Dopamine Homeostasis in SH-SY5Y Cells Through the Modulation of miR-190a and miR-214” 3/15/26
Grok
James V. Kohl (@microRNApro), a researcher focused on miRNA-mediated autophagy and pH-dependent peptide synthesis, argues that PGx, NGS, and FISH tests support light-activated miRNA abundance at life’s origin 6-10,000 years ago, rejecting the ~4.5 billion-year geological timeline referenced in prior discussion.
The post links RNA-directed DNA methylation, enzyme-gene interactions, and COMT Val158Met variants to behaviors analyzed in pharmacogenomic reports, framing these as evidence of biophysically constrained, energy-dependent processes rather than deep-time evolution.
Kohl cites a March 2026 FASEB Journal study showing methylglyoxal reduces dopamine in SH-SY5Y cells by modulating miR-190a and miR-214, connecting cell-level miRNA regulation to his model of nutrient-dependent adaptations and homeostasis.