miRNA-mediated cell types (7)

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The number of new indexed articles prevents me from commenting on each of them, individually. However, they clearly link light-activated miRNA abundance to all biophysically constrained life on Earth via PGx testing for links from energy-dependent miRNA abundance at the origin of life and protection from virus-driven pathology via miRNA modulated tumor suppressor genes in hematologic malignancies linked to solid tumors and behavior.

For today’s additions, see:
Upregulation of miRNA-106a-5p delays diabetic wound healing through reducing the expression of TIMP2 of vascular endothelial cells

“miR-106a-5p inhibited cell proliferation and promoted apoptosis by downregulating TIMP2 expression in vascular endothelial cells, thereby hindering angiogenesis and delaying wound healing.”

Potential of HSP90AA1 as Diagnostic, Prognostic, and Immunological Biomarkers in Human Cancer Demonstrated through Pan-Cancer Investigation: A Bioinformatics Analysis. 3/19/26

“…regions with the most prevalent HSP90AA1 mutation types were found. HSP90AA1’s PPI and miRNA regulatory networks were established…”

A comprehensive analysis of the circRNA, miRNA, and mRNA networks reveals prognostic biomarkers for gastric cancer. 3/20/26

Mitochondrial dysfunction and programmed cell death in Alzheimer’s disease: A retrospective bioinformatics study 3/20/26

Growth hormone (GH) deficiency and subsequent replacement therapy trigger differential expression of specific miRNAs in males and females: not just a matter of height. 3/20/26

Superabundant microRNAs are transcribed from human rDNA spacer promoters insulated by CTCF. 3/20/26

Specific GPCRs elicit unique extracellular vesicle miRNA array signatures. 3/20/26

“…identified unique EV miRNA signatures resulting from GPCR subtype activation. The functional analyses revealed that the predicted gene targets of the EV miRNAs were enriched in distinct metabolic pathways, including physiological and pathological states of cell function. This study offers a novel biological mechanism, EV miRNA content regulation by stimulated GPCRs, and provides insight for future studies of drug-receptor interactions, including unwanted and unintended effects.”

microRNA-155: a versatile noncoding RNA. 3/20/26

“Dysregulated miR-155 expression has been implicated in metabolic disorders, including diabetes and preeclampsia, as well as autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus. Mechanistic and preclinical evidence indicates that aberrant miRNA-155 expression contributes to tumorigenesis by modulating tumor suppressor genes in hematologic malignancies and solid tumors.”

Genome-Wide Identification and Proteomic Analysis of the Wheat ABCG Family Reveal a Pivotal Role of TaABCG7B-8 in Fertility Conversion of a Photoperiod-Temperature-Sensitive Genic Male Sterility Wheat. 3/20/26

All cell type differentiation is energy-dependent and miRNA-mediated See also: miRNA-mediated cell types (8)

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