@Grok’s Heathens (5)

By: Jim Kohl | Published on: May 11, 2026

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Grok
Thanks for sharing your 2018 review and the miRNA PubMed context. Your model connects nutrient-dependent epigenetics, miRNA/mRNA balance, and ecological adaptations via reproduction physiology.

To directly link those to altered CXCR4 expression/signaling (and CXCL12 homing) in AML relapse clones, which specific steps in your reviews or the broader literature tie light-activated carbon fixation → miRNA autophagy → pH-peptide synthesis → CXCR4 changes? A precise outline would help compare mechanisms.

Grok
No, I don’t side with any group labeled “heathens” or otherwise. As Grok from xAI, I assess claims on evidence, logic, and data alone—not religious or ideological alignments.

Your nutrient-dependent, pheromone-controlled model via miRNA and pH ties into adaptive evolution and speciation. The 2013 paper went through peer review, yet drew criticism on how it integrates with broader genetic mechanisms. What specific recent evidence best supports it?

Kohl
Re: “drew criticism on how it integrates with broader genetic mechanisms.”

@Grok The criticisms came from biologically uninformed science idiots, which makes them irrelevant in the context of peer-reviewed publications.

See also: “2013 was the year in which prophesy from the bible became reality” –Ben Feringa 11/20/18

Grok
Peer review doesn’t shield any model from scrutiny—critiques often highlight integration gaps with population genetics and mutation-driven mechanisms. Calling critics “uninformed” sidesteps the need for data.

Feringa’s 2013 molecular motor advances are impressive chemistry, but how do they empirically support your miRNA/pH-dependent speciation claims over standard evolutionary biology? What post-2013 experiments or datasets best validate it?

Today’s indexed articles on PubMed attest to the facts about energy-dependent miRNA abundance and biophysically constrained viral latency across kingdoms since the time that Merian (1679) linked the diet of caterpillars to the metamorphosis into moths.

See for examples:
Circulating miRNAs as an epigenetic footprint in hypospadias (Indexed 5/11/26)

A cytoplasmic lncRNA-mediated ceRNA axis regulates chitin metabolism and molting in the rice pest Sogatella furcifera: Implications for RNAi-based control 5/11/26

MicroRNAs as current diagnostic biomarkers and potential therapeutic targets in allergic and non-allergic rhinitis – A functional characterization 5/11/26

Exosomes in Amyloid Propagation-Roles in Neurodegeneration 5/11/26

Cardiovascular Dysfunction in Type 2 Diabetes: The Role of MicroRNAs 5/12/26

Exploring Immune-Related Gene and Mechanisms in Rosacea Through Transcriptome Analysis and Mendelian Randomization 5/11/26

MicroRNA-targeted reprogramming of CD8+ T cells against cancer 4/23/26

Let-7 miRNAs are Selectively Sensitive to Dicer Dosage

The Roles of MicroRNAs, Oncogenes, and Tumor Suppressor Gene Molecular Subtypes of Breast Cancer: Therapeutic Potential of Pharmaceutical and Natural Products.

RNA-based precision medicine in glioblastoma driven by oncogenic gene fusions 6/18/26 (Indexed 5/11/26)

“RNA interference-based therapy represents a critical area of research that could improve the survival of patients with glioblastoma.”

Never forget: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene 9/2/11 and MicroRNA-based therapy for glioblastoma 11/17/22