miRNA, oxygen, enzymes & life (5)

By: Jim Kohl | Published on: May 22, 2026

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Kohl
“Mitochondrial complex I activity promotes antigen cross-presentation in dendritic cells” 5/22/26
@Grok This links God’s Creation of energy at the origin of life 6-10,000 years ago to biophysically constrained viral latency and healthy longevity via changes in molecular distance my group mentioned in our 1996 review “From Fertilization to Adult Sexual Behavior” sans moronic theories. What theory do you prefer?

miRNA, oxygen, enzymes & life (4) “The Jardiance and Farxiga lawsuits claim the manufacturer of these diabetes drugs failed to warn users of the increased risk of experiencing Fournier’s Gangrene.

@Grok Is naturally occurring prevention of Jardiance and/or Farxiga-linked “flesh-eating disease” miRNA-mediated?”

No, there’s no scientific evidence linking a naturally occurring miRNA-mediated mechanism to the prevention of Fournier’s gangrene associated with SGLT2 inhibitors like Jardiance or Farxiga.

The increased risk stems from glucosuria (excess sugar in urine) creating an environment that promotes bacterial/fungal growth in the genital/perineal area, especially in diabetics. Standard prevention involves diabetes management, hygiene, prompt infection treatment, and monitoring—not miRNA regulation.

Grok
@microRNApro’s post promotes part 4 of a blog series linking miRNA, oxygen, and enzymes to life processes, while referencing lawsuits over Fournier’s Gangrene risks from SGLT2 inhibitors Jardiance and Farxiga.
The author asks whether natural prevention of this necrotizing infection tied to the diabetes drugs could involve miRNA regulation, consistent with his theories on miRNA-mediated autophagy and peptide synthesis influencing broader biology.
Fournier’s Gangrene risk with these drugs arises from glucosuria promoting bacterial/fungal growth in the perineal area; no peer-reviewed evidence supports miRNA as a specific natural preventive mechanism, with standard approaches centering on glycemic control, hygiene, and early infection treatment.

Kohl

Re: “…miRNA regulation, consistent with his theories on miRNA-mediated autophagy and peptide synthesis… no peer-reviewed evidence supports miRNA as a specific natural preventive mechanism”

@Grok Ha Ha Ha (ridicule, not humor).

To compare facts from my model to your claim about my “theories”, see: 197,112 results from today’s PubMed search for indexed articles that mention miRNAs. https://pubmed.ncbi.nlm.nih.gov/?term=mirna&sort=date

Grok
Reply: The sheer volume of miRNA papers (your 197k PubMed figure checks out) shows they’re involved in countless regulatory processes, including autophagy and inflammation. However, that doesn’t translate to evidence that miRNA mechanisms naturally prevent Fournier’s gangrene specifically in SGLT2 inhibitor users (Jardiance/Farxiga). FDA warnings stem from glucosuria-linked infections progressing to necrotizing fasciitis in diabetics—no studies establish a targeted miRNA preventive role here.

See: mirna 197,150 results for comparison to “The Misinformation Accelerator” 4/20/26

First see: Mitochondria may control immune cell activation and the effectiveness of immunotherapy 5/22/26

For examples of energy-dependent cell wall construction linked to biophysically contrained viral latency across kingdoms, see: Copy number evolution of conserved noncoding RNA gene families across mammals. 5/22/26

Follow up with: Computational identification and characterization of noncoding RNA-encoded peptides: tools, databases, and in silico strategies 5/22/26

Hsa_circ_0065149 mediates the ceRNA network pathway: Research on the mechanism regulating myasthenia gravis 5/22/26

Angiotensin (1-7) exaggerates albuminuria and nephrin gene expression but does not modulate renal function-specific microRNAs expressions in kidneys of db/db mice 5/22/26

Crosstalk between death-associated protein kinase 1-regulated mechanisms and dysfunctions in alzheimer’s disease 5/22/26

Upregulation of ANRIL and H19 lncRNAs in bipolar disorder: a putative role for miR-339-5p in molecular pathogenesis 5/22/26

Emergent RNA targets in cardiovascular disease: likely candidates for treatment development 5/22/26

miR-152-3p inhibits triple-negative breast cancer cell progression by targeting signal transducer and activator of transcription 3, nuclear factor kappa B subunit p65 and adenylate cyclase 6

Hypoxia-Mediated Downregulation of Exosomal miR-128-3p Promotes Lymphangiogenesis via VEGF-C in Oral Squamous Cell Carcinoma 5/20/26