A miRNA model vs moronic theories (10)

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A miRNA model vs moronic theories (9)

@Grok For exceptions to facts about biophysically constrained energy-dependent miRNA-mediated protection from virus-driven pathology, see nothing published by intelligent serious scientists in the context of 197,909 results from today’s PubMed search for indexed articles that mention the term miRNA.

Perinatal Nicotine Exposure-Induced Cardiac Phenotype Is Mediated by miR-1-MIAT Interaction and Is Transmitted Transgenerationally 3/24/26

Grok
The March 2026 FASEB paper shows perinatal nicotine exposure dysregulates miR-1/MIAT, elevating CTGF and driving transgenerational cardiac fibrosis in rats via this axis. It demonstrates clear epigenetic transmission of an environmental effect.

The 2015 Science paper correlates lifetime stem cell divisions with tissue-specific cancer risk (r=0.81), attributing ~65% of variation to random replication mutations (“bad luck”) while leaving room for environmental and hereditary factors. It is statistical, not absolute.

miRNA mechanisms, viral latency, plant virus interactions (e.g., in Brugmansia), and elephant TP53 copies provide additional layers. These refine rather than refute the core correlation. Peer-reviewed data from both papers stand independently.

Re: Peer-reviewed data from both papers stand independently.

The peer-reviewed data is not linked to energy-dependent miRNA-mediated life except via model organisms. Theories linked to data do not stand independently, which is why they are useless in the context of facts.

See: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants 11/28/12, “Chemists Know “ 10/6/14, and “All About that Base” 12/10/14

Link “…every angstrom is dynamic from the 5 prime to the three…” to my claims in Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18 via Rosalind Franklin’s claims, or continue to cause unnecessary suffering and premature deaths in the context of misinformation touted by the trillionaire, Elon Musk’s “most dangerous chatbot.”

Kohl
Re: “No single framework captures all findings or lacks refinements from ongoing research. Specific claims benefit from citing primary studies for direct comparison.”

@Grok See: “(Z)-6-{[1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yliminio]methyl}-2-ethoxyphenolate, (Z)-6-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yliminio]methyl}-4-nitratocyclohexa-2,4-dienone monohydrate and (R,E)-2-[(1-hydroxybutan-2-ylimino)methyl]phenol” https://pubmed.ncbi.nlm.nih.gov/16823210 It links my group’s claims from 1996 to all biodiversity on Earth via changes in molecular distance (e.g, hydrogen-atom transfer in DNA base pairs in solution) and effective treatment of PTSD/suicide in veterans and others.

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