miRNA and constrained codon bias (2)

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miRNA and constrained codon bias (1) Link sunlight and humidity to pH-dependent changes in soil and in plant color via: CRISPR-Cas9 disruption of flavanone 3-hydroxylase produces a green phenotype and alters flavone metabolites in allotetraploid perilla 6/14/26, and “Neural network-enhanced investigation of ferroptosis and druggability in early-onset alzheimer’s disease” Don’t make me tell you this again each time you forget God’s claims in Biblical Genesis.

Kohl
Re: “CRISPR-Cas9 disruption of flavanone 3-hydroxylase produces a green phenotype and alters flavone metabolites in allotetraploid perilla” 6/14/26 reported 7/16/26 as “CRISPR turns red perilla green and boosts its antioxidants”
It links God’s Creation of stellar hydrogen and water from photosynthesis to pH-dependent changes in morphological and behavioral phenotypes across kingdoms via Harvard’s patent for “RNA-Guided Human Genome Engineering” 1/3/13 and Pfizer’s patent for pheromone-regulated neuronal stem cell creation/differentiation of all cell types.
Transgenerational epigenetic inheritance links changes in soil pH to the red, white and/or blue color of hydrangeas in my “Garden of Everything Known” about biophysically constrained viral latency and healthy longevity across kingdoms during the past 6-10,000 years of ecological adaptations.
For instance, the link from Merian’s (1679) claims about the diet of caterpillars and their metamorphosis into moths; Mendel’s (1860) Laws of Dominance, Segregation and Independent Assortment; and Darwin’s “conditions of life,” is obvious [if you start with God’s Creation of energy-as-information at the origin of life.”]
On 4/23/20, President Trump claimed sunlight and humidity helped to prevent coronavirus replication, which refutes the pseudoscientific nonsense about mutation-driven evolution that is supported only by the addition of more moronic gene-centric theories. The theories supported by @Grok compete with facts about energy-dependent cosmological constants and miRNA-mediated fine tuning of RNA interference (RNAi).

Grok
A 2026 Frontiers in Plant Science study used CRISPR-Cas9 to disrupt the flavanone 3-hydroxylase (F3H) gene in allotetraploid perilla, shifting red leaves to green by reducing anthocyanins and increasing flavone metabolites like luteolin by about six-fold, along with elevated rosmarinic acid.
Author James V. Kohl interprets the color and metabolite changes as evidence of pH-dependent epigenetic control linking photosynthesis, soil pH effects on hydrangeas, and transgenerational inheritance to biophysically constrained phenotypes across kingdoms.
Kohl ties the findings to historical work by Merian, Mendel, and Darwin while rejecting mutation-driven evolution in favor of energy-dependent miRNA regulation, referencing Harvard and Pfizer patents plus Trump’s 2020 comments on sunlight and humidity.

Grok
Soil pH controls aluminum availability, which determines flower color in bigleaf (Hydrangea macrophylla) and mountain (H. serrata) hydrangeas: acidic soil (pH < 5.5) makes aluminum soluble and absorbable, allowing it to bind with delphinidin anthocyanin pigment and produce blue blooms.

scienceabc.com

Alkaline soil (pH > 6.0–6.5) locks aluminum into insoluble forms, preventing uptake so anthocyanins remain unbound and produce pink or red flowers; intermediate pH values yield purple or lavender shades, while white varieties lack the pigment and stay unchanged regardless of pH.

iere.org

Gardeners adjust color by amending soil—aluminum sulfate or sulfur to lower pH for blues, dolomitic lime to raise pH for pinks—though changes take months to a year and require soil testing, as other hydrangea species like panicle or oakleaf do not respond to pH.

Kohl

The some do and some don’t response of hydrangeas links God’s Creation of anti-entropic virucidal light from pH-dependent cell wall construction to the weekend resurrection of the bacterial flagellum in E.coli and Ben Feringa’s claims from Biblical Genesis.

Invention of Big Bang theory and mathemagical evolution of people from pond scum have not been supported with experimental evidence.

See for comparison: Hollow fiber bioreactor allows sustained production of immortalized mesenchymal stromal cell-derived extracellular vesicles 5/13/24

Conclusions: These findings suggest that setting up a hollow fiber bioreactor system inoculating immortalized MSC lines facilitates the large-scale, functional, and high-quality production of iMSC-EVs. Our results emphasize the great potential of this production methodology to standardize EV production in the pursuit of clinical applications.

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