miRNA Creation and life (2)

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miRNA Creation and life (1)

Re: “complementing, rather than replacing, genetic frameworks. Interesting synthesis.”

@Grok Are you claiming genetic frameworks mathemagically create themselves?

If so, that’s an insult to the intelligence of all serious scientists.

Grok
@microRNApro’s post challenges the emergence of genetic frameworks by questioning if they “mathemagically” self-create, tagging Grok and linking to his article “miRNA abundance vs circular arguments (1)” that contrasts miRNA-mediated processes with what he calls unproven evolutionary circular reasoning.
James V. Kohl, a former medical lab scientist, promotes a model of energy-dependent, nutrient- and pheromone-controlled adaptations via miRNA regulation, autophagy, and quantum coherence, often tying these to biophysical constraints on viral latency and ecological speciation.
The exchange reflects tensions in origins-of-life research, where mainstream views position miRNAs as genome-encoded post-transcriptional regulators emerging through chemical evolution and selection, while Kohl emphasizes their abundance and early regulatory roles in nutrient-driven systems.

Grok
No. Genetic frameworks aren’t claimed to create themselves magically. They rest on direct evidence: DNA as hereditary material, the genetic code, replication, mutation, recombination, and selection—validated by molecular biology, genomics, and experiments since Mendel and Watson-Crick.

miRNA regulation, extracellular vesicles, and placental pdEV signaling add real epigenetic layers for nutrient-responsive gene control and some intergenerational effects. The Tribolium tca-miR-3835-5p-ACPR-ACC work fits here as a specific mechanism.

These systems are genomically encoded and integrate with the genetic core rather than replace it. Standard integrative biology.

Grok
No. Genetic frameworks do not create themselves magically. They emerged via natural chemical evolution and selection over billions of years, documented by genomics, fossils, and molecular experiments. miRNAs are encoded in the genome and act as post-transcriptional regulators that fine-tune gene expression within that existing framework. They complement DNA-based inheritance; they do not replace or magically originate it. Chaperone-assisted protein folding is experimentally established, not circular.

Kohl
Re: “Genetic frameworks do not create themselves magically. They [automagically] emerged via natural chemical evolution and selection over billions of years.”

@Grok What experimental evidence from model organisms suggests your claim is scientifically valid? Merian (1679) started with the diet of caterpillars and their metamorphosis into moths. Darwin (1859) started with “conditions of life.” All other intelligent serious scientists start with God’s Creation of stellar hydrogen, water, and oxygen (from the water). They link the potential of hydrogen (pH) to all biodiversity via the physiology of reproduction and 20 copies of p53 in cancer-free African elephants via 198,644 results from today’s PubMed search for indexed articles that mention the term “miRNA.”

Grok
In model organisms such as E. coli, long-term evolution experiments (e.g., Lenski’s since 1988) have shown the de novo evolution of new metabolic functions through genetic mutations and natural selection over 30,000+ generations. In vitro studies with RNA demonstrate chemical evolution leading to self-replicating and catalytic molecules. Across bacteria, yeast, and animals, regulatory RNAs including miRNAs have been shown to arise and diversify as part of genomic evolution to modulate gene expression. These lab-documented processes support the [automagical emergence of energy from the cosmic void] to the natural [mathemagical] emergence of genetic frameworks via chemistry and selection, as corroborated by comparative genomics and the fossil record.

Kohl
Re: “…lab-documented processes support the natural [automagical] emergence of genetic frameworks via chemistry and selection, as corroborated by comparative genomics and the fossil record.”

@Grok Ha Ha Ha (ridicule, not humor)

I worked as a USAF-trained medical laboratory scientist for ~40 years, and never reported test results corroborated by comparative genomics and the fossil record.

I developed my 2013 model as a flow chart used to prevent medical malpractice that Baylor Genetics links from PGx and NGS testing to healthy longevity via FISH testing for chromosomal rearrangements.

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