miRNA and constrained codon bias (4)

By: Jim Kohl | Published on: July 22, 2026

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miRNA and constrained codon bias (3)
“See the report: Agentic AI in biomedical research: What is it and can it expedite science? 7/21/26

“…we took multiple famous historical scientists, including Albert Einstein and Richard Feynman, and tried to revive them as AI agents, then had them debate scientific questions.“

Feynman, as you may recall, said skip the math and start with food energy.

DeepSeek.com helped me to end math vs food debate with the reply: “Yes, light-regulated humidity and pH-dependent microRNA (miRNA) biogenesis can significantly influence gene expression and development across various organisms, including microbes, plants, and animals, by modulating miRNA abundance.

My “Hometown Hero” article 7/15/26 links “VA Awards Baylor Genetics Multi-Year Contract for Nationwide Pharmacogenomic and Germline Testing 12/15/25 to the end of Grok’s war with Pete Hegseth (the US Secretary of War) via the VA’s claim of my “disruptive behavior.”

To eat or to breathe? 7/9/26 links energy-dependent changes form angstroms to ecosystems in species from rodents and birds via ecological adaptations to high altitude stress. See: Adaptation across an extreme elevational gradient in Andean leaf-eared mice, the world’s highest-dwelling mammal 7/9/26

I was reminded of ecological adaptations in hummingbirds when one visited my patriot-themed “Garden of Everything Known.”

See: Molecular Phylogenetics and the Diversification of Hummingbirds 4/14/14

“…some clades diversified in the context of the uplift of the Andes Mountains, whereas others were affected by the formation of the Panamanian land bridge. Finally, although species accumulation is slowing in all groups of hummingbirds, several major clades maintain rapid rates of diversification on par with classical examples of rapid adaptive radiation.”

Reported as: Hummingbirds’ 22-million-year-old history of remarkable change is far from complete 4/13/14

While all hummingbirds depend on flower nectar to fuel their high metabolisms and hovering flight, coordinated changes in flower and bill shape have helped to drive the formation of new species of both hummingbirds and plants. Remarkably, as many as 25 hummingbird species are able to coexist in some places.

“One of the really cool features of hummingbird evolution is that they all eat the same thing yet have diversified dramatically,” McGuire says. “It really is a big surprise that hummingbirds have divided the nectarivore niche so extensively.”

The claim that hummingbirds evolved across 22 million years can be compared to nutrient-dependent pheromone regulated ecological adaptations during the past 6-10,000 years in species from marine bacteria and soil bacteria to cancer-free African elephants with 20 copies of p53.

See: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants 11/28/12
Combating Evolution to Fight Disease 3/7/14 and US Air Force Studying Impact of Exome Sequencing in Routine Care 10/19/17, the VA’s Million Veteran Program, MilSeq’s “Precision Medicine” and my group’s claims about energy-dependent changes in molecular distance in all sexually differentiated species from yeasts to humans. See: From Fertilization to Adult Sexual Behavior (1996).

For links to the Secretary of War’s claims about the need for testosterone testing in soldiers over 30 years old, see: Nutrient-dependent/pheromone-controlled adaptive evolution: a model

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miRNA and constrained codon bias (4)

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